Compound Summary
zardaverine
Compound Information
zardaverine
Compound Name: | zardaverine |
Compound CID: | 5723 |
Synonyms: | zardaverine 101975-10-4 Zardaverina Zardaverinum 6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone More... |
Iupac Name: | 3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one |
InChI: | InChI=1S/C12H10F2N2O3/c1-18-10-6-7(2-4-9(10)19-12(13)14)8-3-5-11(17)16-15-8/h2-6,12H,1H3,(H,16,17) |
InChIKey: | HJMQDJPMQIHLPB-UHFFFAOYSA-N |
Canonical Smiles: | COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F |
Isomeric Smiles: | COC1=C(C=CC(=C1)C2=NNC(=O)C=C2)OC(F)F |
Molecular Weight: | 268.22 |
Molecular Formula: | C12H10F2N2O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
zardaverine
Molecular Weight: | 268.22 |
Molecular Formula: | C12H10F2N2O3 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 19 |
Complexity: | 398 |
Synonyms
zardaverine
| zardaverine | zardaverine |
|---|---|
zardaverine |
101975-10-4 |
Zardaverina |
Zardaverinum |
6-(4-(Difluoromethoxy)-3-methoxyphenyl)-3(2H)-pyridazinone |
UNII-TQ358GWH6Y |
6-(4-DIFLUOROMETHOXY-3-METHOXY-PHENYL)-2H-PYRIDAZIN-3-ONE |
TQ358GWH6Y |
6-(4-Difluoromethoxy-3-methoxyphenyl)-3(2H)-pyridazinone |
CHEMBL313842 |
3(2H)-Pyridazinone,6-4-(difluoromethoxy)-3-methoxyphenyl- |
6-4-(difluoromethoxy)-3-methoxyphenylpyridazin-3(2H)-one |
CHEBI:46548 |
NCGC00016106-04 |
3-4-(difluoromethoxy)-3-methoxyphenyl-1H-pyridazin-6-one |
CAS-101975-10-4 |
3(2H)-Pyridazinone, 6-4-(difluoromethoxy)-3-methoxyphenyl- CAS |
DSSTox_CID_22559 |
DSSTox_RID_80048 |
DSSTox_GSID_42559 |
Zardaverine INN |
6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one |
6-4-(Difluoromethoxy)-3-methoxyphenyl-3(2H)-pyridazinone |
Zardaverinum INN-Latin |
Zardaverina INN-Spanish |
SMR000449313 |
C12H10F2N2O3 |
SR-01000076204 |
Zaradaverine |
1mkd |
1xor |
Tocris-1046 |
ACMC-20ccb1 |
Prestwick0_000977 |
Prestwick1_000977 |
Prestwick2_000977 |
Prestwick3_000977 |
Lopac-Z-3003 |
UPCMLD-DP159 |
Lopac0_001260 |
SCHEMBL13334 |
BSPBio_001013 |
BSPBio_001346 |
KBioGR_000066 |
KBioSS_000066 |
MLS000758207 |
MLS001401422 |
SPBio_002924 |
BPBio1_001115 |
DTXSID8042559 |
SCHEMBL14810549 |
UPCMLD-DP159:001 |
UPCMLD-DP159:002 |
BDBM14769 |
KBio2_000066 |
KBio2_002634 |
KBio2_005202 |
KBio3_000131 |
KBio3_000132 |
Bio2_000066 |
Bio2_000546 |
HMS1361D08 |
HMS1571C15 |
HMS1791D08 |
HMS1989D08 |
HMS2051O09 |
HMS2090L06 |
HMS2098C15 |
HMS2235H08 |
HMS3267C08 |
HMS3370L18 |
HMS3393O09 |
HMS3402D08 |
HMS3412C09 |
HMS3676C09 |
HMS3715C15 |
BCP06509 |
ZINC9230249 |
Tox21_110307 |
4165AH |
MFCD00867059 |
AKOS024456348 |
Tox21_110307_1 |
Zardaverine phosphodiesterase inhibitor |
CCG-100782 |
CCG-205334 |
DB02918 |
NC00032 |
Zardaverine, phosphodiesterase inhibitor |
IDI1_033816 |
NCGC00016106-01 |
NCGC00016106-02 |
NCGC00016106-03 |
NCGC00016106-05 |
NCGC00016106-06 |
NCGC00016106-07 |
NCGC00016106-08 |
NCGC00016106-09 |
NCGC00016106-10 |
NCGC00016106-11 |
NCGC00016106-13 |
NCGC00024963-01 |
NCGC00024963-02 |
NCGC00024963-03 |
NCGC00024963-04 |
NCGC00024963-05 |
BZ161227 |
HY-15485 |
SBI-0051227.P002 |
AB00513983 |
EU-0101260 |
FT-0631019 |
Z 3003 |
AB00513983-03 |
A902439 |
J-000529 |
SR-01000076204-1 |
SR-01000076204-3 |
SR-01000076204-5 |
BRD-K37561857-001-04-9 |
BRD-K37561857-001-06-4 |
BRD-K37561857-001-13-0 |
Q15634082 |
6-(4-difluoromethoxy-3-methoxy-phenyl)-32h-pyridazinone |
6-4-(difluoromethoxy)-3-methoxyphenyl-2,3-dihydropyridazin-3-one |
6-(3,4-Dimethoxy-phenyl)-4,5-dimethyl-4,5-dihydro-2H-pyridazin-3-one |
Experimental Data
zardaverine
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 7.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
zardaverine
Statistics Data
zardaverine
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 7.000000000000000 | 1 | 1 |
Statistics Data Visualization
zardaverine
