Compound Summary
trichostatin A
Compound Information
trichostatin A
Compound Name: | trichostatin A |
Compound CID: | 444732 |
Synonyms: | trichostatin A 58880-19-6 Trichostatin TSA Trichostatin A (TSA) More... |
Iupac Name: | (2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
InChI: | InChI=1S/C17H22N2O3/c1-12(5-10-16(20)18-22)11-13(2)17(21)14-6-8-15(9-7-14)19(3)4/h5-11,13,22H,1-4H3,(H,18,20)/b10-5+,12-11+/t13-/m1/s1 |
InChIKey: | RTKIYFITIVXBLE-QEQCGCAPSA-N |
Canonical Smiles: | CC(C=C(C)C=CC(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
Isomeric Smiles: | C[C@H](/C=C(\C)/C=C/C(=O)NO)C(=O)C1=CC=C(C=C1)N(C)C |
Molecular Weight: | 302.37 |
Molecular Formula: | C17H22N2O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
trichostatin A
Molecular Weight: | 302.37 |
Molecular Formula: | C17H22N2O3 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 22 |
Complexity: | 447 |
Synonyms
trichostatin A
| trichostatin A | trichostatin A |
|---|---|
trichostatin A |
58880-19-6 |
Trichostatin |
TSA |
Trichostatin A (TSA) |
(2E,4E,6R)-7-4-(Dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
UNII-3X2S926L3Z |
Antibiotic A-300 |
CHEBI:46024 |
C17H22N2O3 |
(R,2E,4E)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxohepta-2,4-dienamide |
GNF-PF-1011 |
3X2S926L3Z |
58880-19-6 (R-isomer) |
2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo- |
7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
MFCD03848392 |
A-300-I |
(2E,4E,6R)-7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
R-(E,E)-7-4-(Dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide |
2,4-Heptadienamide, 7-4-(dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- |
Trichostatin-A |
Tricostatin A |
7-4-(DIMETHYLAMINO)PHENYL-N-HYDROXY-4,6-DIMETHYL-7-OXO-2,4-HEPTADIENAMIDE |
2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- |
TSN |
Trichostatina |
trichostatine a |
Trichlostatin A |
Trichostatin(s) |
(2E,4E,6R)-7-(4-dimethylaminophenyl)-4,6-dimethyl-7-oxo-hepta-2,4-dienehydroxamic acid |
(2E,4E,6R)-7-(4-Dimethylaminophenyl)-N-hydroxy-4,6-dimethyl-7-oxo-hepta-2,4-dienamide |
Trichostatin A,TSA |
(R)-Trichostatin A |
NCGC_TSA |
1c3r |
3f0r |
Trichostatin-A - TSA |
SCHEMBL19886 |
cc-238 |
MLS006011095 |
SGCTO-002 |
SCHEMBL675951 |
GTPL7005 |
DTXSID6037063 |
CHEBI:93196 |
BCPP000035 |
HMS1362L09 |
HMS1792L09 |
HMS1990L09 |
HMS3403L09 |
HMS3649O20 |
BCP01776 |
EX-A1665 |
Trichostatin A, Ready Made Solution |
BDBM50005711 |
LMPK01000055 |
s1045 |
Trichostatin A from Streptomyces sp. |
AKOS015899840 |
ZINC100014731 |
CCG-208142 |
CCG-208681 |
CS-0499 |
DB04297 |
NSC 311042 |
NCGC00162453-01 |
NCGC00162453-02 |
NCGC00162453-03 |
NCGC00162453-04 |
NCGC00162453-05 |
NCGC00162453-15 |
3C10 |
AS-74315 |
HY-15144 |
M984 |
SMR004702883 |
A8183 |
SW219664-1 |
T2477 |
A25618 |
M02571 |
880T196 |
Q425894 |
SR-05000013796 |
Q-201864 |
SR-05000013796-3 |
BRD-K68202742-001-04-1 |
BRD-K68202742-001-05-8 |
Trichostatin A, >=98% (HPLC), from Streptomyces sp. |
Trichostatin A, Streptomyces sp. - CAS 58880-19-6 |
UNII-30RHG284Z4 component RTKIYFITIVXBLE-QEQCGCAPSA-N |
Trichostatin A??, Vetec(TM) reagent grade, from Streptomyces sp., >=98% |
(2E,4E,6R)-7-(4-(Dimethylamino)phen yl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamid e |
(6R)-N-Hydroxy-4,6-dimethyl-7-oxo-7-4-(dimethylamino)phenyl-2,4-heptadienamide |
7-4-(Dimethylamino)phenyl-N-hydroxy-4,6R-dimethyl-7-oxo-2E,4E-heptadienamide |
2,4-Heptadienamide, 7-4-(dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- (9CI) |
2,4-Heptadienamide, 7-4-(dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxo-, R-(E,E)- |
2,4-Heptadienamide,7-4-(dimethylamino)phenyl-N-hydroxy-4,6-dimethyl-7-oxo-, (2E,4E,6R)- |
Experimental Data
trichostatin A
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 50.000000000000000 | umol/L | 3.690000000000000 | NS | N2 | 30970250 | Inactive | ||||||
| Drosophila melanogaster | 10.000000000000000 | ug/mol | 24.400000000000000 | 16.400000000000000 | S | Canton-S | 15695762 | Active | |||||
| Caenorhabditis elegans | 100.000000000000000 | umol/L | 22.600000000000000 | S | N2 | 33683565 | Active | ||||||
| Caenorhabditis elegans | 200.000000000000000 | umol/L | 23.800000000000000 | S | N2 | 33683565 | Active | ||||||
| Drosophila melanogaster | 10.000000000000000 | umol/L | 27.300000000000000 | 37.900000000000000 | S | Canton-S | FEMALES | 15346199 | Active | ||||
| Drosophila melanogaster | 10.000000000000000 | umol/L | 23.300000000000000 | 37.000000000000000 | S | Canton-S | MALES | 15346199 | Active | ||||
| Caenorhabditis elegans | 100.000000000000000 | umol/L | 23.140000000000000 | 28.380000000000000 | 22.120000000000000 | S | N2 | 26676933 | Active |
Experimental Data Visualization
trichostatin A
Statistics Data
trichostatin A
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 23.800000000000000 | 3 | 4 | |
| Drosophila melanogaster | 27.300000000000000 | 37.900000000000000 | 2 | 3 |
Statistics Data Visualization
trichostatin A
