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Compound Summary

tolbutamide

Compound Information

tolbutamide

Compound Name:	tolbutamide
Compound CID:	5505
Synonyms:	tolbutamide 64-77-7 Orinase Artosin 1-Butyl-3-tosylurea More...
Iupac Name:	1-butyl-3-(4-methylphenyl)sulfonylurea
InChI:	InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)
InChIKey:	JLRGJRBPOGGCBT-UHFFFAOYSA-N
Canonical Smiles:	CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
Isomeric Smiles:	CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C
Molecular Weight:	270.35
Molecular Formula:	C12H18N2O3S

Compound Structure

2D Structure:

3D Structure:

Computed Properties

tolbutamide

Molecular Weight:	270.35
Molecular Formula:	C12H18N2O3S
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	3
Rotatable Bond Count:	5
Heavy Atom Count:	18
Complexity:	354

Synonyms

tolbutamide

tolbutamide	tolbutamide
tolbutamide	64-77-7
Orinase	Artosin
1-Butyl-3-tosylurea	Tolbutamid
Aglicid	Arkozal
Diabetol	Dolipol
Rastinon	Tolumid
Diaben	Orabet
Tolylsulfonylbutylurea	Willbutamide
Butamide	Diabetamid
Diabuton	Diasulfon
Dirastan	Glyconon
Ipoglicone	Pramidex
Tolbusal	Artozin
Butamid	Drabet
Mobenol	Oralin
Orezan	Orinaz
Oterben	Toluina
Toluvan	1-Butyl-3-(p-tolylsulfonyl)urea
Sk-tolbutamide	N-n-Butyl-N-tosylurea
Tolbutamida	Tolbutamidum
N-(Butylcarbamoyl)-4-methylbenzenesulfonamide	1-Butyl-3-(p-methylphenylsulfonyl)urea
1-p-Toluenesulfonyl-3-butylurea	N-Butyl-N-(p-tolylsulfonyl)urea"
N-Butyl-N-p-toluenesulfonylurea	3-(p-Tolyl-4-sulfonyl)-1-butylurea
N-(4-Methylphenylsulfonyl)-N-butylurea"	N-Butyl-N-(4-methylphenylsulfonyl)urea"
N-(4-Methylbenzenesulfonyl)-N-butylurea	HLS 831
Orinase (TN)	Benzenesulfonamide, N-(butylamino)carbonyl-4-methyl-
1-butyl-3-(4-methylphenyl)sulfonylurea	N-(Sulfonyl-p-methylbenzene)-N-N-butylurea
Urea, 1-butyl-3-(p-tolylsulfonyl)-	N-(p-Tolylsulfonyl)-N-butylcarbamide
NCI-C01763	N-4-Methylbenzolsulfonyl-N-butylurea
N-(butylamino)carbonyl-4-methylbenzenesulfonamide	D 860
N-Butyl-N-toluene-p-sulfonylurea	UNII-982XCM1FOI
1-Butyl-3-(4-methylphenylsulfonyl)urea	3-butyl-1-(4-methylbenzenesulfonyl)urea
N-(p-Methylbenzenesulfonyl)-N-butylurea	3-butyl-1-(4-methylbenzene)sulfonylurea
MFCD00027169	1-BUTYL-3-(4-METHYLBENZENESULFONYL)UREA
CHEMBL782	982XCM1FOI
Benzenesulfonamide, N-((butylamino)carbonyl)-4-methyl-	MLS000028399
Arcosal	Beglucin
Butamidum	Diabesan
Tarasina	Tolbutone
CHEBI:27999	Tolbet
N-((Butylamino)carbonyl)-4-methylbenzenesulfonamide	NSC-23813
CAS-64-77-7	NCGC00015999-10
SMR000058363	Tolbutamide form I^L^
DSSTox_CID_1359	DSSTox_RID_76106
DSSTox_GSID_21359	Tolbutamidum INN-Latin
Tolbutamida INN-Spanish	Tolumide
CCRIS 592	N-4-(Methylbenzolsulfonyl)-n-butylurea
NSC-87833	HSDB 3393
SR-01000003059	EINECS 200-594-3
NSC 23813	U 2043
(butylamino)-N-(4-methylphenyl)sulfonylcarboxamide	BRN 1984428
N-(Sulfonyl-p-methylbenzene)-N-butylurea	tolbutamide IL
tolbutamide III	Tolbutamide USP:INN:BAN:JAN
Prestwick_471	Spectrum_000447
Tolbutamide form I^H^	Opera_ID_112
Prestwick0_000190	Prestwick1_000190
Prestwick2_000190	Prestwick3_000190
Spectrum2_001210	Spectrum3_000599
Spectrum4_000358	Spectrum5_001272
Lopac-T-0891	N-n-Butyl-N-tosylurea
WLN: 4MVMSWR D1	T 0891
NCIOpen2_009592	BIDD:PXR0179
CBiol_001920	Lopac0_001154
SCHEMBL15918	BSPBio_000119
BSPBio_001507	BSPBio_002078
KBioGR_000227	KBioGR_000795
KBioGR_002275	KBioSS_000227
KBioSS_000927	KBioSS_002276
4-11-00-00396 (Beilstein Handbook Reference)	MLS001148399
MLS002152944	Toluina\|\|\|Tolumid\|\|\|Orinase
DivK1c_000341	SPECTRUM1500581
SPBio_001000	SPBio_002040
BPBio1_000131	GTPL6848
Tolbutamide (JP17/USP/INN)	Tolbutamide, analytical standard
DTXSID8021359	HMS501B03
KBio1_000341	KBio2_000227
KBio2_000927	KBio2_002275
KBio2_002795	KBio2_003495
KBio2_004843	KBio2_005363
KBio2_006063	KBio2_007411
KBio3_000453	KBio3_000454
KBio3_001578	KBio3_002755
cMAP_000008	NINDS_000341
1-Butyl-3-(p-tolylsulfonoyl)urea	Bio1_000206
Bio1_000695	Bio1_001184
Bio2_000227	Bio2_000707
HMS1361L09	HMS1568F21
HMS1791L09	HMS1989L09
HMS2089C17	HMS2092M21
HMS2095F21	HMS2232H16
HMS3259A08	HMS3263H09
HMS3402L09	HMS3651N03
HMS3712F21	Pharmakon1600-01500581
BCP09192	HY-B0401
NSC23813	ZINC1530703
N-Butyl-N-(p-tolylsulfonyl)urea	Tox21_110279
Tox21_201612	Tox21_302795
Tox21_501154	BDBM50027886
CCG-39141	NSC757354
s2443	SBB058188
1-Butyl-3-(para-tolylsulfonyl)-urea	AKOS015894999
Tox21_110279_1	1-(p-toluenesulfonyl)-3-n-butyl-urea
DB01124	LP01154
MCULE-9720356859	NC00543
NSC-757354	SDCCGSBI-0051121.P004
Tolbutamide 1.0 mg/ml in Acetonitrile	IDI1_000341
IDI1_033977	N-(n-Butyl)-N-p-toluene-sulfonylurea
NCGC00015999-01	NCGC00015999-02
NCGC00015999-03	NCGC00015999-04
NCGC00015999-05	NCGC00015999-06
NCGC00015999-07	NCGC00015999-08
NCGC00015999-09	NCGC00015999-11
NCGC00015999-12	NCGC00015999-13
NCGC00015999-14	NCGC00015999-15
NCGC00015999-16	NCGC00015999-17
NCGC00015999-19	NCGC00015999-20
NCGC00015999-29	NCGC00022721-03
NCGC00022721-04	NCGC00022721-05
NCGC00022721-06	NCGC00022721-07
NCGC00022721-08	NCGC00022721-09
NCGC00022721-10	NCGC00256548-01
NCGC00259161-01	NCGC00261839-01
AC-12490	AS-14136
K045	N-(4-Methylphenylsulfonyl)-N-butylurea"
N-Butyl-N-(4-methylphenylsulfonyl)urea	SBI-0051121.P003
DB-054728	AB00052110
EU-0101154	FT-0603265
ST50409552	SW196681-3
T3690	BIM-0051121.0001
C07148	D00380
D87667	J10018
U-2043	AB00052110-16
AB00052110_17	AB00052110_18
Tolbutamide, VETRANAL(TM), analytical standard	A834879
Q414275	SR-01000003059-2
SR-01000003059-4	SR-01000003059-7
W-104820	BRD-K85119730-001-06-5
BRD-K85119730-001-17-2	N-butyl-N-(p-tolylsulfonyl)carbamimidate;Tolbutamide
Z44591715	Tolbutamide, European Pharmacopoeia (EP) Reference Standard
1-(((Butylamino)carbonylamino)sulfonyl)-4-methylbenzene #	Tolbutamide, United States Pharmacopeia (USP) Reference Standard

Experimental Data

tolbutamide

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	33.000000000000000	umol/L			6.000000000000000				NS	N2		24134630	Inactive

Experimental Data Visualization

tolbutamide

Statistics Data

tolbutamide

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	6.000000000000000		1	1

Statistics Data Visualization

tolbutamide

Compound Name:

tolbutamide

Compound CID:

5505

Synonyms:

tolbutamide 64-77-7 Orinase Artosin 1-Butyl-3-tosylurea More...

Iupac Name:

1-butyl-3-(4-methylphenyl)sulfonylurea

InChI:

InChI=1S/C12H18N2O3S/c1-3-4-9-13-12(15)14-18(16,17)11-7-5-10(2)6-8-11/h5-8H,3-4,9H2,1-2H3,(H2,13,14,15)

InChIKey:

JLRGJRBPOGGCBT-UHFFFAOYSA-N

Canonical Smiles:

CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Isomeric Smiles:

CCCCNC(=O)NS(=O)(=O)C1=CC=C(C=C1)C

Molecular Weight:

270.35

Molecular Formula:

C12H18N2O3S

Molecular Weight:

270.35

Molecular Formula:

C12H18N2O3S

Hydrogen Bond Donor Count:

2

Hydrogen Bond Acceptor Count:

3

Rotatable Bond Count:

5

Heavy Atom Count:

18

Complexity:

354

tolbutamide

64-77-7

Orinase

Artosin

1-Butyl-3-tosylurea

Tolbutamid

Aglicid

Arkozal

Diabetol

Dolipol

Rastinon

Tolumid

Diaben

Orabet

Tolylsulfonylbutylurea

Willbutamide

Butamide

Diabetamid

Diabuton

Diasulfon

Dirastan

Glyconon

Ipoglicone

Pramidex

Tolbusal

Artozin

Butamid

Drabet

Mobenol

Oralin

Orezan

Orinaz

Oterben

Toluina

Toluvan

1-Butyl-3-(p-tolylsulfonyl)urea

Sk-tolbutamide

N-n-Butyl-N-tosylurea

Tolbutamida

Tolbutamidum

N-(Butylcarbamoyl)-4-methylbenzenesulfonamide

1-Butyl-3-(p-methylphenylsulfonyl)urea

1-p-Toluenesulfonyl-3-butylurea

N-Butyl-N-(p-tolylsulfonyl)urea"

N-Butyl-N-p-toluenesulfonylurea

3-(p-Tolyl-4-sulfonyl)-1-butylurea

tolbutamide

64-77-7

Orinase

Artosin

1-Butyl-3-tosylurea

More...