Compound Summary
staurosporine
Compound Information
staurosporine
Compound Name: | staurosporine |
Compound CID: | 44259 |
Synonyms: | staurosporine Staurosporin 62996-74-1 (+)-Staurosporine Antibiotic 230 More... |
Iupac Name: | (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one |
InChI: | InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)/t17-,20-,26-,28+/m1/s1 |
InChIKey: | HKSZLNNOFSGOKW-FYTWVXJKSA-N |
Canonical Smiles: | CC12C(C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC |
Isomeric Smiles: | C[C@@]12[C@@H]([C@@H](C[C@@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC |
Molecular Weight: | 466.5 |
Molecular Formula: | C28H26N4O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
staurosporine
Molecular Weight: | 466.5 |
Molecular Formula: | C28H26N4O3 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 2 |
Heavy Atom Count: | 35 |
Complexity: | 901 |
Synonyms
staurosporine
| staurosporine | staurosporine |
|---|---|
staurosporine |
Staurosporin |
62996-74-1 |
(+)-Staurosporine |
Antibiotic 230 |
Antibiotic AM 2282 |
AM-2282 |
CCRIS 3272 |
Antibiotic AM-2282 |
UNII-H88EPA0A3N |
Alkaloid AM-2282 from Streptomyces |
H88EPA0A3N |
CHEMBL388978 |
CHEBI:15738 |
8,12-Epoxy-1H,8H-2,7b,12a-triazadibenzo(a,g)cyclonona(cde)trinden-1-one, 2,3,9,10,11,12-hexahydro-9-methoxy-8-methyl-10-(methylamino)-, (8alpha,9beta,10beta,12alpha)-(+)- |
(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-17-oxa-4b,9a,15-triaza-5,9-methanodibenzob,hcyclononajklcyclopentae-as-indacen-14-one |
(5S,6R,7R,9R)-6-methoxy-5-methyl-7-methylamino-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzob,hcyclonona1,2,3,4-jklcyclopentae-as-indacen-14-one |
GNF-PF-1389 |
methoxy-methyl-(methylamino)?one |
SR-00000001485 |
Staurosporin, 4 |
1nvr |
1stc |
1xbc |
1xjd |
1yhs |
2gcd |
Staurosporine, 8 |
CGP 39360 |
Staurosporine & TNF |
1q3d |
1sm2 |
2dq7 |
MolMap_000047 |
SCHEMBL8157 |
CBiol_001978 |
BSPBio_001146 |
GTPL346 |
BDBM2579 |
MEGxm0_000307 |
DTXSID6041131 |
1u59 |
BCPP000063 |
Bio1_000264 |
Bio1_000753 |
Bio1_001242 |
HMS1990J07 |
HMS3650B17 |
EX-A1777 |
ZINC3814434 |
AM2282 |
NSC755774 |
s1421 |
AKOS015897119 |
AM 2282 |
CCG-208052 |
DB02010 |
NSC-755774 |
QTL1_000078 |
NCGC00162400-01 |
NCGC00162400-02 |
NCGC00162400-03 |
NCGC00162400-04 |
NCGC00162400-05 |
NCGC00162400-06 |
NCGC00162400-09 |
9,13-Epoxy-1H,9H-diindolo(1,2,3-gh:3,2,1-lm)pyrrolo(3,4-j)(1,7)-benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S-(9alpha,10beta,11beta,13alpha)- |
HY-15141 |
ST50826371 |
Staurosporine & Tumor necrosis factor (TNF) |
Staurosporine 100 microg/mL in Acetonitrile |
7158-EP2270008A1 |
7158-EP2289893A1 |
7158-EP2292617A1 |
7158-EP2308855A1 |
7158-EP2308883A1 |
7158-EP2311809A1 |
7158-EP2311842A2 |
Q5957181 |
SR-00000001485-4 |
BRD-K17953061-001-02-8 |
BRD-K17953061-001-04-4 |
BRD-K17953061-001-05-1 |
BRD-K17953061-001-08-5 |
BRD-K17953061-001-10-1 |
BRD-K17953061-001-11-9 |
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo 12.12.2.1<2,6>.0<7,28>.0<8,13>.0<15,19>.0<20,27>.0<21,26>nonacosa-8(13),9,11 ,14(28),15(19),20(27),21(26),22,24-nonaen-16-one |
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-16-one |
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo12.12.2.1^{2,6}.0^{7,28}.0^{8,13}.0^{15,19}.0^{20,27}.0^{21,26}nonacosa-8,10,12,14(28),15(19),20(27),21,23,25-nonaen-16-one |
(2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo12.12.2.12,6.07,28.08,13.015,19.020,27.021,26nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-one |
(5S,6R,7R,9R)-6-methoxy-5-methyl-7-(methylamino)-6,7,8,9,15,16-hexahydro-5H,14H-5,9-epoxy-4b,9a,15-triazadibenzob,hcyclonona1,2,3,4-jklcyclopentae-as-indacen-14-one |
9S-(9?,10?,11?,13?)-2,3,10,11,12,13-Hexahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one |
109189-95-9 |
9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)- & Tumor necrosis factor (TNF)" |
9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, (9S,10R,11R,13R)- (9CI)" |
9,13-Epoxy-1H,9H-diindolo1,2,3-gh:3,2,1-lmpyrrolo3,4-j1,7benzodiazonin-1-one, 2,3,10,11,12,13-hexahydro-10-methoxy-9-methyl-11-(methylamino)-, 9S-(9alpha,10beta,11beta,13alpha)-" |
Experimental Data
staurosporine
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 34.800000000000000 | S | Oregon-R | 22363408 | Active |
Experimental Data Visualization
staurosporine
Statistics Data
staurosporine
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 34.800000000000000 | 1 | 1 |
Statistics Data Visualization
staurosporine
