Compound Summary

physostigmine
  Compound Information
 physostigmine

Compound Name:

physostigmine

Compound CID:

5983

Synonyms:

physostigmine

Eserine

57-47-6

Antilirium

Physostol

More...

Iupac Name:

[(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo[2,3-b]indol-7-yl] N-methylcarbamate

InChI:

InChI=1S/C15H21N3O2/c1-15-7-8-17(3)13(15)18(4)12-6-5-10(9-11(12)15)20-14(19)16-2/h5-6,9,13H,7-8H2,1-4H3,(H,16,19)/t13-,15+/m1/s1

InChIKey:

PIJVFDBKTWXHHD-HIFRSBDPSA-N

Canonical Smiles:

CC12CCN(C1N(C3=C2C=C(C=C3)OC(=O)NC)C)C

Isomeric Smiles:

C[C@@]12CCN([C@@H]1N(C3=C2C=C(C=C3)OC(=O)NC)C)C

Molecular Weight:

275.35

Molecular Formula:

C15H21N3O2

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 physostigmine

Molecular Weight:

275.35

Molecular Formula:

C15H21N3O2

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

4

Rotatable Bond Count:

2

Heavy Atom Count:

20

Complexity:

403

  Synonyms
 physostigmine

physostigmine physostigmine

physostigmine

Eserine

57-47-6

Antilirium

Physostol

Esromiotin

Ezerin

Calabarine

Erserine

Fysostigmin

(-)-physostigmine

(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo2,3-bindol-5-yl methylcarbamate

Eserolein, methylcarbamate (ester)

UNII-9U1VM840SP

Eserine sulfate

CHEMBL94

9U1VM840SP

CHEBI:27953

NSC30782

NSC-30782

NCGC00093889-03

DSSTox_CID_3471

DSSTox_RID_77040

DSSTox_GSID_23471

Fysostigmin Czech

(3aR,8bS)-3,4,8b-trimethyl-2,3a-dihydro-1H-pyrrolo2,3-bindol-7-yl N-methylcarbamate

CHEMBL537674

Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-

CAS-57-47-6

CCRIS 3422

HSDB 3161

MCV 4484

EINECS 200-332-8

Eserolein, methylcarbamate

NIH 10421

NSC 30782

Physostigmine USP:BAN

RCRA waste no. P204

physostigmin

CS 58525

Methyl-carbamic acid, ester with eseroline

Carbamic acid, methyl-, ester with eseroline

(-) physostigmine

Eserine (TN)

Physostigmine (USP)

Physostigmine free base

Spectrum_000916

Spectrum_001789

SpecPlus_000381

Prestwick0_000566

Prestwick1_000566

Prestwick2_000566

Prestwick3_000566

Spectrum2_000330

Spectrum2_000757

Spectrum2_001283

Spectrum3_000545

Spectrum3_000901

Spectrum4_000997

Spectrum4_001631

Spectrum4_001913

Spectrum5_000441

Spectrum5_000626

Spectrum5_001672

physostigmine.salicylic acid

1,2,3,3abeta,8abeta-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)-indol-5-yl methylcarbamate

Lopac0_000483

SCHEMBL24044

BSPBio_000352

BSPBio_002189

KBioGR_001433

KBioGR_002061

KBioGR_002533

KBioSS_001396

KBioSS_002279

(3aS-cis)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo(2,3-b)indol-5-ol methylcarbamate (ester)

MLS001304022

DivK1c_006477

SPECTRUM1500753

SPBio_000339

SPBio_000774

SPBio_001285

SPBio_002571

BPBio1_000388

cid_657348

GTPL6598

MEGxp0_001872

DTXSID3023471

ACon1_000097

BDBM11023

KBio1_001421

KBio2_001396

KBio2_002278

KBio2_003964

KBio2_004846

KBio2_006532

KBio2_007414

KBio3_001689

KBio3_001842

Eserine, >=98.0% (N)

HMS1921G06

HMS2089M11

HMS2236L08

HMS3261B07

BCP19735

Carbamic acid, ester with eseroline

HY-N6608

MCV-4484

Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-methylcarbamate), (3aS,8aR)-

Tox21_111228

Tox21_301591

Tox21_500483

BDBM50004000

BDBM50222010

CCG-38605

MFCD00151090

ZINC91689892

AKOS016843649

Tox21_111228_1

DB00981

LP00483

MCULE-2638001883

MCULE-9310809074

SDCCGMLS-0066585.P001

SDCCGSBI-0050467.P005

NCGC00093889-01

NCGC00093889-02

NCGC00093889-04

NCGC00093889-05

NCGC00093889-06

NCGC00093889-07

NCGC00093889-08

NCGC00093889-09

NCGC00093889-10

NCGC00093889-12

NCGC00093889-13

NCGC00093889-20

NCGC00255345-01

NCGC00261168-01

AC-15983

Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS,8aR)-

Pyrrolo(2,3-b)indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)

SMR000718753

SBI-0050467.P004

CS-0034353

EU-0100483

P0406

Physostigmine 100 microg/mL in Acetonitrile

C06535

D00196

E 8375

Q410595

Eserine; Antilirium; Physostol; Esromiotin; Ezerin

SR-01000075341-1

WLN: T B556 EN GNTT&J B1 E1 G1 KOVM1

BRD-K25650355-001-02-5

BRD-K25650355-059-02-3

BRD-K25650355-059-12-2

(3aS,8aR)-1,3a,8-trimethyl-1,2,3,3a,8,8a-hexahydropyrrolo2,3-bindol-5-yl methylcarbamate hydrochloride

(3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo2,3-bindol-5-yl N-methylcarbamate

(3aS,8aR)-1,3a,8-trimethyl-1H,2H,3H,3aH,8H,8aH-pyrrolo2,3-bindol-5-yl N-methylcarbamate; 2-hydroxybenzoic acid

Pyrrolo2, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, methylcarbamate (ester), (3aS-cis)-
  Experimental Data
 physostigmine

Species Dose Unit Control(Avg days) Treatment(Avg days) Avg/Med Lifespan Change(%) Control(Max days) Treatment(Max days) Max Lifespan Change(%) Significant Strain Gender PubMed Avg/Med Lifespan Change tab
Caenorhabditis elegans 33.000000000000000 umol/L 11.000000000000000 NS N2 24134630 Inactive
Caenorhabditis elegans 100.000000000000000 umol/L 15.990000000000000 16.670000000000000 4.205000000000000 NS N2 33008901 Inactive
Drosophila melanogaster 200.000000000000000 umol/L 42.220000000000000 41.630000000000000 -1.390000000000000 NS MALES 33008901 Inactive
Caenorhabditis elegans 10.000000000000000 umol/L 16.180000000000000 15.760000000000000 -2.570000000000000 NS N2 33008901 Inactive
Drosophila melanogaster 20.000000000000000 umol/L 47.990000000000000 48.450000000000000 0.970000000000000 NS FEMALES 33008901 Inactive
  Experimental Data Visualization
 physostigmine

  Statistics Data
 physostigmine

Species Avg/Med Lifespan Change(%) Max Lifespan Change(%) Count Reference Count Data point
Caenorhabditis elegans 11.000000000000000 2 3
Drosophila melanogaster 0.970000000000000 1 2
  Statistics Data Visualization
 physostigmine

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