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Compound Summary

nifedipine

Compound Information

nifedipine

Compound Name:	nifedipine
Compound CID:	4485
Synonyms:	nifedipine 21829-25-4 Adalat Procardia Procardia XL More...
Iupac Name:	dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChI:	InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3
InChIKey:	HYIMSNHJOBLJNT-UHFFFAOYSA-N
Canonical Smiles:	CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Isomeric Smiles:	CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC
Molecular Weight:	346.3
Molecular Formula:	C17H18N2O6

Compound Structure

2D Structure:

3D Structure:

Computed Properties

nifedipine

Molecular Weight:	346.3
Molecular Formula:	C17H18N2O6
Hydrogen Bond Donor Count:	1
Hydrogen Bond Acceptor Count:	7
Rotatable Bond Count:	5
Heavy Atom Count:	25
Complexity:	608

Synonyms

nifedipine

nifedipine	nifedipine
nifedipine	21829-25-4
Adalat	Procardia
Procardia XL	Adalat CC
Cordipin	Corinfar
Fenihidine	Citilat
Oxcord	dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
Bay-a-1040	Fenihidin
Adalate	Nifediac
Afeditab CR	Coracten
Hexadilat	Introcar
Kordafen	Nifedical
Tibricol	Adapine
Anifed	Pidilat
Sepamit	Zenusin
Orix	Adalat LA
Nifedipinum	Nifedipino
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester	3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester
BAY A 1040	Adipine XL
C17H18N2O6	MFCD00057326
Nifedipine (Adalat)	CCRIS 6074
CHEBI:7565	Coracten XL
3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate	CHEMBL193
UNII-I9ZF7L6G2L	I9ZF7L6G2L
MLS000028521	Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-3,5-pyridinedicarboxylate	NCGC00015748-11
Chronadalate	Dignokonstant
Adapress	Afeditab
Aldipin	Alfadal
Angipec	Aprical
Bonacid	Calcibloc
Calcigard	Calcilat
Cardifen	Cardilat
Cardionorm	Cordafen
Cordaflex	Cordalat
Cordicant	Cordilan
Corotrend	Corynphar
Dilafed	Dipinkor
Duranifin	Ecodipi
Ecodipin	Fenamon
Hadipin	Macorel
Megalat	Myogard
Nifecard	Nifecor
Nifedicor	Nifedin
Nifedipres	Nifelan
Nifelat	Nificard
SMR000058291	Alonix
Anpine	Camont
Fedcor	Glopir
Coral	Depin
Alat	Adalat Retard
CAS-21829-25-4	Fedcor Retard
Adalat Crono	Chronadalate LP
Adalat Oros	4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
DSSTox_CID_5715	Ecodipin E
Apo-Nifed	Nifensar XL
Alonix S	Fenamon SR
Dimethyl 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylate	Adalat CR
Adalat FT	Adalat LP
Adalat PA	Adalat GITS
DSSTox_RID_77889	Adalat 5
DSSTox_GSID_25715	Adalat 10
Adalat 20	Adalat GITS 30
Alpha-Nifedipine Retard	Emaberin
Dilcor	Aprical long
Slofedipine XL	Fortipine LA
Nifedical XL	Nifedipinum INN-Latin
Tensipine MR	4-(2-Nitrophenyl)-2,6-dimethyl-3,5-dicarbomethoxy-1,4-dihydropyridine
Adalate LP	Nifedipino INN-Spanish
Adalat XL	4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester
Dimethyl 4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate	Procardia (TN)
Adalat (TN)	Afeditab CR (TN)
1173023-46-5	SR-01000075332
BAYa1040	Aldipine
Nifedipine,(S)	BAY 1040
KB-1712P	methyl 5-(methoxycarbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine- 3-carboxylate
Prestwick_357	EINECS 244-598-3
Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate	BRN 0497773
Nifedipine-13C8	Spectrum_000979
Tocris-1075	Opera_ID_1816
Prestwick0_000063	Prestwick1_000063
Prestwick2_000063	Prestwick3_000063
Spectrum2_001058	Spectrum3_000516
Spectrum4_000074	Spectrum5_001278
Lopac-N-7634	N 7634
cid_4485	SCHEMBL3968
BIDD:PXR0034	CBiol_001826
Lopac0_000819	Oprea1_788617
BSPBio_000245	BSPBio_001391
BSPBio_002071	KBioGR_000111
KBioGR_000627	KBioGR_002400
KBioSS_000111	KBioSS_001459
KBioSS_002405	MLS000758222
MLS001148146	MLS001401371
ARONIS24171	BIDD:GT0442
DivK1c_000313	SPECTRUM1500431
SPBio_001016	SPBio_002166
BPBio1_000271	GTPL2514
Nifedipine (JP17/USP/INN)	BAY-a 1040
DTXSID2025715	BCBcMAP01_000046
HMS500P15	HSDB 7775
KBio1_000313	KBio2_000111
KBio2_001459	KBio2_002400
KBio2_002679	KBio2_004027
KBio2_004968	KBio2_005247
KBio2_006595	KBio2_007536
KBio3_000221	KBio3_000222
KBio3_001571	KBio3_002879
SYN3028	cMAP_000042
Nifedipine-d4(2-nitrophenyl-d4)	NINDS_000313
Bio1_000112	Bio1_000601
Bio1_001090	Bio2_000111
Bio2_000591	HMS1361F13
HMS1568M07	HMS1791F13
HMS1920P19	HMS1989F13
HMS2051O03	HMS2089H11
HMS2091H20	HMS2095M07
HMS2233B22	HMS3262D19
HMS3267G06	HMS3393O03
HMS3412E17	HMS3651M19
HMS3676E17	HMS3712M07
HMS3748O21	Pharmakon1600-01500431
ACT02669	BCP21147
HY-B0284	Tox21_110212
Tox21_200304	Tox21_500819
BBL023163	BDBM50000778
BDBM50101817	CCG-40115
NSC757242	NSC786036
s1808	SBB012573
STK735567	ZINC85205448
AKOS002942507	AKOS037515769
Nifedipine - CAS 21829-25-4	Nifedipine, >=98% (HPLC), powder
Tox21_110212_1	AC-8061
CCG-100758	DB01115
KS-1456	LP00819
MCULE-7336870265	NC00008
Nifedipine USAN:USP:INN:BAN:JAN	NSC 757242
NSC-757242	NSC-786036
SDCCGSBI-0050796.P005	4-(2-Nitrophenyl)-2,6-dimethyl-1,4-dihydropyridin-3,5-dicarbonsaeuredimethylester German
IDI1_000313	IDI1_033861
Bay-1040;Bay 1040;Bay1040	NCGC00015748-01
NCGC00015748-02	NCGC00015748-03
NCGC00015748-04	NCGC00015748-05
NCGC00015748-06	NCGC00015748-07
NCGC00015748-08	NCGC00015748-09
NCGC00015748-10	NCGC00015748-12
NCGC00015748-13	NCGC00015748-14
NCGC00015748-15	NCGC00015748-17
NCGC00015748-33	NCGC00021710-02
NCGC00024983-01	NCGC00024983-02
NCGC00024983-03	NCGC00024983-04
NCGC00024983-05	NCGC00024983-06
NCGC00024983-07	NCGC00024983-08
NCGC00091707-01	NCGC00091707-02
NCGC00091707-03	NCGC00257858-01
NCGC00261504-01	BN166183
CPD000058291	ST066898
SY074220	SBI-0050796.P004
AB0012099	EU-0100819
FT-0630478	FT-0653833
FT-0672727	N0528
SW219724-1	29N254
BIM-0050796.0001	C07266
D00437	Q39111
AB00052051-05	AB00052051_06
AB00052051_07	5-22-04-00268 (Beilstein Handbook Reference)
A899873	L001054
Q-201471	SR-01000075332-1
SR-01000075332-3	SR-01000075332-4
SR-01000075332-6	BRD-K96354014-001-01-3
BRD-K96354014-001-10-4	Z90350374
F2173-0802	Nifedipine, British Pharmacopoeia (BP) Reference Standard
Nifedipine, European Pharmacopoeia (EP) Reference Standard	Nifedipine, United States Pharmacopeia (USP) Reference Standard
2,6-Dimethyl-3,5-dicarbomethoxy-4-(2-nitrophenyl)-1,4-dihydropyridine	4-(2-nitrophenyl)-2,6 dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine"
4-(2-nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridine	Nifedipine, Pharmaceutical Secondary Standard; Certified Reference Material
1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylicaciddimethylester	2,6-dimethyl-4-(2nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-dimethyl ester
Dimethyl (4-(2-nitrophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate)	Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylate #
101539-70-2	3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester (9CI)
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(o-nitrophenyl)-, dimethyl ester (8CI)

Experimental Data

nifedipine

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	33.000000000000000	umol/L			6.000000000000000				NS	N2		24134630	Inactive

Experimental Data Visualization

nifedipine

Statistics Data

nifedipine

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	6.000000000000000		1	1

Statistics Data Visualization

nifedipine

Compound Name:

nifedipine

Compound CID:

4485

Synonyms:

nifedipine 21829-25-4 Adalat Procardia Procardia XL More...

Iupac Name:

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

InChI:

InChI=1S/C17H18N2O6/c1-9-13(16(20)24-3)15(14(10(2)18-9)17(21)25-4)11-7-5-6-8-12(11)19(22)23/h5-8,15,18H,1-4H3

InChIKey:

HYIMSNHJOBLJNT-UHFFFAOYSA-N

Canonical Smiles:

CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

Isomeric Smiles:

CC1=C(C(C(=C(N1)C)C(=O)OC)C2=CC=CC=C2[N+](=O)[O-])C(=O)OC

Molecular Weight:

346.3

Molecular Formula:

C17H18N2O6

Molecular Weight:

346.3

Molecular Formula:

C17H18N2O6

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

7

Rotatable Bond Count:

5

Heavy Atom Count:

25

Complexity:

608

nifedipine

21829-25-4

Adalat

Procardia

Procardia XL

Adalat CC

Cordipin

Corinfar

Fenihidine

Citilat

Oxcord

dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

Bay-a-1040

Fenihidin

Adalate

Nifediac

Afeditab CR

Coracten

Hexadilat

Introcar

Kordafen

Nifedical

Tibricol

Adapine

Anifed

Pidilat

Sepamit

Zenusin

Orix

Adalat LA

Nifedipinum

Nifedipino

1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester

3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, dimethyl ester

BAY A 1040

Adipine XL

C17H18N2O6

MFCD00057326

Nifedipine (Adalat)

CCRIS 6074

CHEBI:7565

Coracten XL

3,5-dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate

CHEMBL193

UNII-I9ZF7L6G2L

I9ZF7L6G2L

nifedipine

21829-25-4

Adalat

Procardia

Procardia XL

More...