Compound Summary

metformin
  Compound Information
 metformin

Compound Name:

metformin

Compound CID:

4091

Synonyms:

metformin

657-24-9

1,1-Dimethylbiguanide

N,N-dimethylimidodicarbonimidic diamide

Metformine

More...

Iupac Name:

3-(diaminomethylidene)-1,1-dimethylguanidine

InChI:

InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)

InChIKey:

XZWYZXLIPXDOLR-UHFFFAOYSA-N

Canonical Smiles:

CN(C)C(=N)N=C(N)N

Isomeric Smiles:

CN(C)C(=N)N=C(N)N

Molecular Weight:

129.16

Molecular Formula:

C4H11N5

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 metformin

Molecular Weight:

129.16

Molecular Formula:

C4H11N5

Hydrogen Bond Donor Count:

3

Hydrogen Bond Acceptor Count:

1

Rotatable Bond Count:

2

Heavy Atom Count:

9

Complexity:

132

  Synonyms
 metformin

metformin metformin

metformin

657-24-9

1,1-Dimethylbiguanide

N,N-dimethylimidodicarbonimidic diamide

Metformine

Metiguanide

Dimethylbiguanide

Haurymelin

Fluamine

Flumamine

Gliguanid

Diabex

Melbin

N,N-Dimethylbiguanide

Glumetza

Imidodicarbonimidic diamide, N,N-dimethyl-

N1,N1-Dimethylbiguanide

DMGG

NNDG

N,N-Dimethyldiguanide

3-(diaminomethylidene)-1,1-dimethylguanidine

1,1-Dimethyl biguanide

LA-6023

BIGUANIDE, 1,1-DIMETHYL-

Fortamet

UNII-9100L32L2N

CHEMBL1431

CHEBI:6801

Glifage

Islotin

Siofor

Dimethyldiguanide

Diaformin

9100L32L2N

Metformina DCIT

Metforminum

Metformina

Metformina Spanish

Metformine INN-French

Metforminum INN-Latin

Metformin USAN:INN:BAN

MLS000028493

14Cmetformin

14C-metformin

C4H11N5

657M249

Metformin (USAN/INN)

NCGC00016564-01

SMR000058277

EINECS 211-517-8

CAS-1115-70-4

Dianben

Obimet

Dimethylbiguanid

Metformin base

CCRIS 9321

N-dimethylbiguanide

DMBG

Glucophage (Salt/Mix)

n,n-dimethylbiguanide

Imidodicarbonimidic diamide-, N,N-dimethyl-

Prestwick0_000004

Prestwick1_000004

Prestwick2_000004

Prestwick3_000004

DSSTox_CID_3270

N,N-Dimethylguanylguanidin

SCHEMBL8944

DSSTox_RID_76950

DSSTox_GSID_23270

BSPBio_000007

BSPBio_002314

KBioGR_002310

KBioSS_002312

cid_14219

LA 6023 (Salt/Mix)

BIDD:GT0697

SPBio_001928

BPBio1_000009

GTPL4503

GTPL4779

SCHEMBL9913821

DTXSID2023270

SCHEMBL10276396

BDBM57047

KBio2_002310

KBio2_004878

KBio2_007446

KBio3_002790

cMAP_000016

HMS2089D19

HY-B0627

Tox21_302370

BBL012337

BDBM50229665

HSCI1_000295

s5958

STK011633

STL483693

STL484070

ZINC12859773

AKOS000121065

AKOS005206848

AKOS015966566

CCG-102605

DB00331

MCULE-7393156510

3-carbamimidoyl-1,1-dimethyl-guanidine

NCGC00016564-02

NCGC00016564-03

NCGC00016564-05

NCGC00016564-07

NCGC00188959-01

NCGC00255255-01

AC-32484

AS-65365

CAS-657-24-9

K070

SBI-0206876.P001

1-carbamimidamido-N,N-dimethylmethanimidamide

CS-0009563

FT-0628266

A19551

C07151

D04966

D72476

Q19484

(E)-3-Amino(dimethylamino)methylideneguanidine

1-(E)-amino(dimethylamino)methylideneguanidine

15673-EP2269977A2

15673-EP2269989A1

15673-EP2270007A1

15673-EP2270011A1

15673-EP2272825A2

15673-EP2272834A1

15673-EP2272841A1

15673-EP2275108A1

15673-EP2275414A1

15673-EP2280001A1

15673-EP2287165A2

15673-EP2287166A2

15673-EP2292228A1

15673-EP2292620A2

15673-EP2295406A1

15673-EP2295409A1

15673-EP2295411A1

15673-EP2295422A2

15673-EP2298742A1

15673-EP2298769A1

15673-EP2298772A1

15673-EP2298776A1

15673-EP2298779A1

15673-EP2301533A1

15673-EP2301923A1

15673-EP2301929A1

15673-EP2301935A1

15673-EP2301936A1

15673-EP2305648A1

15673-EP2305674A1

15673-EP2308839A1

15673-EP2308847A1

15673-EP2308878A2

15673-EP2314576A1

15673-EP2314588A1

15673-EP2316470A2

W-109589

BRD-K79602928-003-04-1

BRD-K79602928-003-08-2

3-(diaminomethylene)-1,1-dimethyl-guanidine;hydrochloride

3-bis(azanyl)methylidene-1,1-dimethyl-guanidine;hydrochloride

MF8

  Experimental Data
 metformin

Species Dose Unit Control(Avg days) Treatment(Avg days) Avg/Med Lifespan Change(%) Control(Max days) Treatment(Max days) Max Lifespan Change(%) Significant Strain Gender PubMed Avg/Med Lifespan Change tab
Drosophila melanogaster 5.000000000000000 mM 36.000000000000000 40.000000000000000 0.110000000000000 S w1118 36394755 Active
Drosophila melanogaster 10.000000000000000 mM 36.000000000000000 36.000000000000000 0.000000000000000 NS w1118 36394755 Inactive
Mus musculus 1.000000000000000 % -1.000000000000000 -6.000000000000000 S C57BL/6J 29167747 Inactive
Mus musculus 706.000000000000000 742.000000000000000 5.100000000000000 930.000000000000000 966.000000000000000 3.900000000000000 S 129/Sv FEMALES 21084729 Active
Caenorhabditis elegans 50.000000000000000 mM 17.940000000000000 22.420000000000000 0.250000000000000 S N2 27984722 Active
Acheta domesticus 0.001780000000000 g 41.400000000000000 74.100000000000000 0.790000000000000 136.000000000000000 188.000000000000000 0.380000000000000 S 25833406 Active
Mus musculus 1000.000000000000000 ppm 874.000000000000000 872.000000000000000 0.000000000000000 1092.000000000000000 1094.000000000000000 0.000000000000000 NS C2011 FEMALES 27312235 Inactive
Mus musculus 1000.000000000000000 ppm 780.000000000000000 835.000000000000000 7.000000000000000 1064.000000000000000 1046.000000000000000 -2.000000000000000 NS C2011 MALES 27312235 Inactive
Drosophila melanogaster 1.000000000000000 mM 57.000000000000000 59.000000000000000 0.040000000000000 NS Dahomey MALES 23077661 Inactive
Caenorhabditis elegans 20.000000000000000 mM 14.000000000000000 16.000000000000000 14.300000000000000 S N2 29263362 Active
Mus musculus 100.000000000000000 mg/kg 264.000000000000000 285.000000000000000 8.000000000000000 311.000000000000000 340.000000000000000 16.200000000000000 S FVB/N FEMALES 21084729 Active
Drosophila melanogaster 5.000000000000000 mM 54.000000000000000 58.000000000000000 0.070000000000000 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 10.000000000000000 mM 54.000000000000000 51.000000000000000 -0.060000000000000 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 10.000000000000000 mM 65.000000000000000 63.000000000000000 -0.030000000000000 NS Dahomey FEMALES 23077661 Inactive
Mus musculus 1.000000000000000 % -5.000000000000000 -3.000000000000000 S C57BL/6J 29167747 Inactive
Drosophila melanogaster 5.000000000000000 mM 65.000000000000000 65.000000000000000 0.000000000000000 NS Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 5.000000000000000 mM 57.000000000000000 57.000000000000000 0.000000000000000 NS Dahomey MALES 23077661 Inactive
Mus musculus 662.000000000000000 573.000000000000000 -13.400000000000000 1029.000000000000000 1044.000000000000000 0.010000000000000 S 129/Sv MALES 21084729 Inactive
Caenorhabditis elegans 20.000000000000000 mM 15.000000000000000 17.000000000000000 13.300000000000000 S N2 29263362 Active
Drosophila melanogaster 25.000000000000000 mM 54.000000000000000 51.000000000000000 -0.060000000000000 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 2.500000000000000 mM 67.000000000000000 67.000000000000000 0.000000000000000 NS Dahomey FEMALES 23077661 Inactive
Mus musculus 0.100000000000000 % 5.830000000000000 S C57BL/6 MALES 23900241 Active
Caenorhabditis elegans 50.000000000000000 mM 43.650000000000000 S N2 29027899 Active
Caenorhabditis elegans 50.000000000000000 mM 15.000000000000000 21.000000000000000 40.000000000000000 0.000000000000000 S N2 20090912 Active
Mus musculus 1.000000000000000 % -14.400000000000000 S C57BL/6 MALES 23900241 Inactive
Acheta domesticus 0.001780000000000 g 97.900000000000000 143.700000000000000 0.470000000000000 130.000000000000000 188.000000000000000 0.450000000000000 S 25833406 Active
Drosophila melanogaster 5.000000000000000 mM 67.000000000000000 67.000000000000000 0.000000000000000 NS Dahomey FEMALES 23077661 Inactive
Mus musculus 388.000000000000000 535.000000000000000 37.900000000000000 814.000000000000000 898.000000000000000 10.300000000000000 S SHR FEMALES 21084729 Active
Mus musculus 285.000000000000000 304.000000000000000 0.070000000000000 396.000000000000000 359.000000000000000 -0.090000000000000 NS FVB/N FEMALES 21084729 Inactive
Drosophila melanogaster 100.000000000000000 mM 54.000000000000000 37.000000000000000 -0.310000000000000 S Dahomey MALES 23077661 Inactive
Drosophila melanogaster 50.000000000000000 mM 54.000000000000000 51.000000000000000 -0.060000000000000 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 50.000000000000000 mM 65.000000000000000 51.000000000000000 -0.220000000000000 S Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 25.000000000000000 mM 65.000000000000000 58.000000000000000 -0.110000000000000 S Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 100.000000000000000 mM 65.000000000000000 22.000000000000000 -0.660000000000000 S Dahomey FEMALES 23077661 Inactive
Caenorhabditis elegans 100.000000000000000 mM 16.000000000000000 17.700000000000000 0.110000000000000 NS N2 24889636 Inactive
Acheta domesticus 0.001780000000000 g 88.900000000000000 123.200000000000000 0.390000000000000 136.000000000000000 183.000000000000000 0.350000000000000 S 25833406 Active
Caenorhabditis elegans 50.000000000000000 mM 16.000000000000000 17.900000000000000 0.120000000000000 NS N2 24889636 Inactive
Drosophila melanogaster 1.000000000000000 mM 67.000000000000000 67.000000000000000 0.000000000000000 NS Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 2.500000000000000 mM 57.000000000000000 55.000000000000000 -0.040000000000000 NS Dahomey MALES 23077661 Inactive
Caenorhabditis elegans 25.000000000000000 mM 16.000000000000000 21.500000000000000 0.340000000000000 S N2 24889636 Active
Caenorhabditis elegans 6.250000000000000 mM 16.000000000000000 19.000000000000000 0.190000000000000 S N2 24889636 Active
Caenorhabditis elegans 12.500000000000000 mM 16.000000000000000 18.000000000000000 0.120000000000000 S N2 24889636 Active
Caenorhabditis elegans 25.000000000000000 mM 18.000000000000000 S N2 23540700 Active
Caenorhabditis elegans 50.000000000000000 mM 36.000000000000000 S N2 23540700 Active
Caenorhabditis elegans 100.000000000000000 mM 3.000000000000000 S N2 23540700 Active
  Experimental Data Visualization
 metformin

  Statistics Data
 metformin

Species Avg/Med Lifespan Change(%) Max Lifespan Change(%) Count Reference Count Data point
Acheta domesticus 0.790000000000000 0.450000000000000 1 3
Caenorhabditis elegans 43.650000000000000 0.000000000000000 6 13
Drosophila melanogaster 0.110000000000000 2 18
Mus musculus 37.900000000000000 16.200000000000000 4 11
  Statistics Data Visualization
 metformin

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