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Compound Summary

loxapine

Compound Information

loxapine

Compound Name:	loxapine
Compound CID:	3964
Synonyms:	loxapine Cloxazepine Oxilapine 1977-10-2 Loxitane More...
Iupac Name:	8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine
InChI:	InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3
InChIKey:	XJGVXQDUIWGIRW-UHFFFAOYSA-N
Canonical Smiles:	CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Isomeric Smiles:	CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl
Molecular Weight:	327.8
Molecular Formula:	C18H18ClN3O

Compound Structure

2D Structure:

3D Structure:

Computed Properties

loxapine

Molecular Weight:	327.8
Molecular Formula:	C18H18ClN3O
Hydrogen Bond Donor Count:	0
Hydrogen Bond Acceptor Count:	3
Rotatable Bond Count:	1
Heavy Atom Count:	23
Complexity:	450

Synonyms

loxapine

loxapine	loxapine
loxapine	Cloxazepine
Oxilapine	1977-10-2
Loxitane	Loxapin
Dibenzacepin	Dibenzoazepine
Adasuve	Loxapina
Loxapinum	CL-62362
SUM 3170	Loxitane IM
HF3170	HF 3170
LW 3170	2-chloro-11-(4-methylpiperazin-1-yl)dibenzob,f1,4oxazepine
Dibenzb,f1,4oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-	S-805
SUM-3170	8-chloro-6-(4-methylpiperazin-1-yl)benzob1,4benzoxazepine
CHEMBL831	C18H18ClN3O
UNII-LER583670J	CHEBI:50841
LER583670J	Lossapina DCIT
Hydrofluoride 3170	CL 62,362
2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine	2-Chloro-11-(4-methyl-1-piperazinyl)dibenzb,f1,4oxazepine
Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-	Loxapinum INN-Latin
Loxapina INN-Spanish	CL-71563
Lossapina	Loxapine USAN:INN:BAN
AZ-004	Loxapine (USAN/INN)
CL 62362	S 805
Staccato loxapine	HSDB 3111
Loxapine (water)	Loxapine (DMSO)
Adasuve (TN)	EINECS 217-835-3
Loxitane Intramuscular	BRN 0626753
Spectrum_000355	2-Chloro-11-(4-methylpiperazino)dibenzo(b,f)(1,4)oxazepine
CL71,563	SpecPlus_000823
8-chloro-6-(4-methylpiperazin-1-yl)benzob1,5benzoxazepine	Prestwick0_000132
Prestwick1_000132	Prestwick2_000132
Prestwick3_000132	Spectrum2_001737
Spectrum3_001830	Spectrum5_001857
Loxitane-C Oral Suspension	Lopac0_000720
SCHEMBL94146	BSPBio_000204
BSPBio_003479	GTPL205
KBioSS_000835	DivK1c_006919
SPBio_001814	SPBio_002143
BPBio1_000226	DTXSID7023229
BDBM22871	KBio1_001863
KBio2_000835	KBio2_003403
KBio2_005971	KBio3_002983
3785AH	PDSP1_001058
PDSP2_001042	s5197
ZINC19796158	CCG-204805
CS-1105	DB00408
SDCCGSBI-0050698.P003	QTL1_000050
NCGC00021145-01	NCGC00021145-02
NCGC00021145-03	NCGC00021145-04
NCGC00021145-05	NCGC00021145-06
NCGC00021145-07	NCGC00021145-08
NCGC00021145-23	NCGC00022279-03
NCGC00022279-04	NCGC00022279-05
HY-17390	C07104
D02340	Q58614
AB00053735_15	AB00053735_16
977L102	L001085
BRD-K39915878-036-04-6	BRD-K39915878-036-05-3
BRD-K39915878-036-15-2	2-Chloro-11-(4-methylpiperazino)dibenzb,f1,4oxazepine
8-chloro-6-(4-methylpiperazino)benzob1,4benzoxazepine;succinic acid	13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo9.4.0.0^{3,8}pentadeca-1(11),3(8),4,6,9,12,14-heptaene
13-chloro-10-(4-methylpiperazin-1-yl)-2-oxa-9-azatricyclo9.4.0.0^{3,8}pentadeca-1(11),3,5,7,9,12,14-heptaene

Experimental Data

loxapine

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Drosophila melanogaster	20.000000000000000	umol/L	48.860000000000000	47.130000000000000	-3.536000000000000				NS		FEMALES	33008901	Inactive
Drosophila melanogaster	200.000000000000000	umol/L	44.010000000000000	43.890000000000000	-0.279600000000000				NS		MALES	33008901	Inactive

Experimental Data Visualization

loxapine

Statistics Data

loxapine

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Drosophila melanogaster	-0.279600000000000		1	2

Statistics Data Visualization

loxapine

Compound Name:

loxapine

Compound CID:

3964

Synonyms:

loxapine Cloxazepine Oxilapine 1977-10-2 Loxitane More...

Iupac Name:

8-chloro-6-(4-methylpiperazin-1-yl)benzo[b][1,4]benzoxazepine

InChI:

InChI=1S/C18H18ClN3O/c1-21-8-10-22(11-9-21)18-14-12-13(19)6-7-16(14)23-17-5-3-2-4-15(17)20-18/h2-7,12H,8-11H2,1H3

InChIKey:

XJGVXQDUIWGIRW-UHFFFAOYSA-N

Canonical Smiles:

CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl

Isomeric Smiles:

CN1CCN(CC1)C2=NC3=CC=CC=C3OC4=C2C=C(C=C4)Cl

Molecular Weight:

327.8

Molecular Formula:

C18H18ClN3O

Molecular Weight:

327.8

Molecular Formula:

C18H18ClN3O

Hydrogen Bond Donor Count:

0

Hydrogen Bond Acceptor Count:

3

Rotatable Bond Count:

1

Heavy Atom Count:

23

Complexity:

450

loxapine

Cloxazepine

Oxilapine

1977-10-2

Loxitane

Loxapin

Dibenzacepin

Dibenzoazepine

Adasuve

Loxapina

Loxapinum

CL-62362

SUM 3170

Loxitane IM

HF3170

HF 3170

LW 3170

2-chloro-11-(4-methylpiperazin-1-yl)dibenzob,f1,4oxazepine

Dibenzb,f1,4oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

S-805

SUM-3170

8-chloro-6-(4-methylpiperazin-1-yl)benzob1,4benzoxazepine

CHEMBL831

C18H18ClN3O

UNII-LER583670J

CHEBI:50841

LER583670J

Lossapina DCIT

Hydrofluoride 3170

CL 62,362

2-Chloro-11-(4-methyl-1-piperazinyl)dibenz(b,f)(1,4)oxazepine

2-Chloro-11-(4-methyl-1-piperazinyl)dibenzb,f1,4oxazepine

Dibenz(b,f)(1,4)oxazepine, 2-chloro-11-(4-methyl-1-piperazinyl)-

Loxapinum INN-Latin

Loxapina INN-Spanish

CL-71563

Lossapina

Loxapine USAN:INN:BAN

AZ-004

Loxapine (USAN/INN)

CL 62362

S 805

Staccato loxapine

HSDB 3111

Loxapine (water)

Loxapine (DMSO)

loxapine

Cloxazepine

Oxilapine

1977-10-2

Loxitane

More...