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Compound Summary

hydrochlorothiazide

Compound Information

hydrochlorothiazide

Compound Name:	hydrochlorothiazide
Compound CID:	3639
Synonyms:	hydrochlorothiazide 58-93-5 HCTZ Esidrix Hypothiazide More...
Iupac Name:	6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
InChI:	InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)
InChIKey:	JZUFKLXOESDKRF-UHFFFAOYSA-N
Canonical Smiles:	C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Isomeric Smiles:	C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl
Molecular Weight:	297.7
Molecular Formula:	C7H8ClN3O4S2

Compound Structure

2D Structure:

3D Structure:

Computed Properties

hydrochlorothiazide

Molecular Weight:	297.7
Molecular Formula:	C7H8ClN3O4S2
Hydrogen Bond Donor Count:	3
Hydrogen Bond Acceptor Count:	7
Rotatable Bond Count:	1
Heavy Atom Count:	17
Complexity:	494

Synonyms

hydrochlorothiazide

hydrochlorothiazide	hydrochlorothiazide
hydrochlorothiazide	58-93-5
HCTZ	Esidrix
Hypothiazide	Oretic
Dichlotiazid	Hidrotiazida
Hydrochlorothiazid	Hydrochlorthiazide
Hydrodiuretic	Hydrosaluric
Servithiazid	Aquarills
Aquarius	Dichlotride
Diclotride	Disalunil
Hypothiazid	Idrotiazide
Maschitt	Megadiuril
Newtolide	Thiuretic
Vetidrex	Drenol
Esidrex	Hidril
Hydril	Nefrix
Chlorosulthiadil	Hidrochlortiazid
Hydro-Diuril	Hydro-Aquil
Dihydrochlorothiazide	Jen-Diril
HydroDIURIL	Dihydrochlorothiazid
Dihydrochlorothiazidum	Apresazide
Carozide	Chlorzide
Dichlorosal	Hidroronol
Hydrothide	Hydrozide
Moduretic	Neoflumen
Urodiazin	Bremil
Cidrex	Diaqua
Direma	Dyazide
Fluvin	Ivaugan
Panurin	Ro-hydrazide
Neo-codema	Acuretic
Caplaril	Hydrocot
Microzide	Thlaretic
Timolide	Aquazide H
Lotensin HCT	6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
3,4-Dihydrochlorothiazide	Thiaretic
Vaseretic	Ziac
Zide	Apo-Hydro
Lopressor HCT	Hydro-D
Hydrochlorothiazidum	Unipres
Dihydrochlorurit	Dihydrochlorurite
Hidroclorotiazida	Su 5879
Aldactazide	Inderide
Maxzide	Prinzide
Hydrochlorothiazide Intensol	NCI-C55925
component of Cyclex	component of Esimil
Esidrix (TN)	Ser-Ap-Es
C7H8ClN3O4S2	component of Aldoril
component of Dyazide	component of Caplaril
HCZ	Chlorsulfonamidodihydrobenzothiadiazine dioxide
component of Aldactazide	UNII-0J48LPH2TH
component of Butizide Prestabs	2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6},2,4-benzothiadiazine-7-sulfonamide	Diu-melusin
0J48LPH2TH	6-Chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine-7-sulfonamide 1,1-Dioxide
MLS000069619	CHEBI:5778
Chlorizide	Disothiazid
Hidrosaluretil	Novodiurex
Spironazide	Acesistem
Acuilix	Aldazida
Briazide	Catiazida
Chlothia	Clorana
Condiuren	Dihydran
Diurogen	Dixidrasi
Esoidrina	H.H. 25/25
H.H. 50/50	Hyclosid
Indroclor	Manuril
Medozide	Mictrin
Mikorten	Modurcen
Natrinax	Pantemon
Saldiuril	Selozide
Tandiur	Urozide
Didral	Hytrid
Nefrol	Unazid
Hidro-Niagrin	Hydro-Saluric
Raunova Plus	3,4-Dihydro-6-chloro-7-sulfamyl-1,2,4-benzothiadiazine-1,1-dioxide
6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine 1,1-dioxide	Concor Plus
Aquazide-H	Neo-Flumen
Neo-Minzil	6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine 1,1-dioxide
6-Chloro-7-sulfamoyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide	Hydro Par
NSC53477	6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide
6-chloro-3,4-dihydro-2H-benzoe1,2,4thiadiazine-7-sulfonamide 1,1-dioxide	Hydro-T
Hydrochlorthiazidum	MFCD00051765
NSC-53477	HCT
HCT-Isis	CAS-58-93-5
Mazide 25 mg	NCGC00015508-08
Hydrochlorat	Hydrochlorot
SMR000035778	Idroclorotiazide
Diu 25 Vigt	Hydrex-semi
Aldactazide 25/25	Aldectazide 50/50
Dihydroxychlorothiazidum	DSSTox_CID_713
Inderide 80/25	Hydrochlorothiazide form II
6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide-1,1-dioxide	Idroclorotiazide DCIT
DSSTox_RID_75752	DSSTox_GSID_20713
Hydrochlorzide	Ezide
Hydrozide Injection, Veterinary	Hidroclorotiazida INN-Spanish
Hydrochlorothiazidum INN-Latin	6-chloro-1,1-dioxo-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide
Microzide (TN)	CCRIS 2082
HSDB 3096	SR-01000000119
EINECS 200-403-3	NSC 53477
BRN 0625101	Hydrokraft
Idrodiuvis	Aquazide
Manschitt	Urirex
HydroPar	6-chloro-1,1-dioxo-2H,3H,4H-benzoe1,2,4-thiadiazine-7-sulfonamide
6-chloro-1,1-dioxo-3,4-dihydro-2H-1?^{6},2,4-benzothiadiazine-7-sulfonamide	Prestwick_263
Hydrochloro Thiazide	Hyzaar (Salt/Mix)
Aldoril (Salt/Mix)	Dutoprol (Salt/Mix)
Inderide (Salt/Mix)	Prinzide (Salt/Mix)
Accuretic (Salt/Mix)	Hydropres (Salt/Mix)
Thiazide, hydrochloro-	Hydrochlorothiazide USP:INN:BAN:JAN
Spectrum_000877	Opera_ID_168
Maybridge1_004336	Prestwick0_000009
Prestwick1_000009	Prestwick2_000009
Prestwick3_000009	Spectrum2_001040
Spectrum3_000456	Spectrum4_000006
Spectrum5_000824	Lopac-H-4759
CHEMBL435	Tekturna HCT (Salt/Mix)
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide	H 4759
cid_3639	SCHEMBL9349
Lopac0_000614	Oprea1_357174
BSPBio_000017	BSPBio_002132
KBioGR_000351	KBioSS_001357
AF-614/30832002	ARONIS24316
BIDD:GT0153	DivK1c_000289
SPECTRUM1500335	BMCL182567 Compound 6a
SPBio_001259	SPBio_001938
BPBio1_000019	GTPL4836
Hydrochlorothiazide, crystalline	DTXSID2020713
BDBM13076	component of Dyazide (Salt/Mix)
HMS500O11	HMS553N04
KBio1_000289	KBio2_001357
KBio2_003925	KBio2_006493
KBio3_001352	component of Caplaril (Salt/Mix)
NINDS_000289	HMS1568A19
HMS1920D19	HMS2091L05
HMS2095A19	HMS2235I09
HMS3259O17	HMS3261L10
HMS3370P11	HMS3428A05
HMS3655M21	HMS3712A19
Pharmakon1600-01500335	ZINC896569
BCP22001	EBD18905
HY-B0252	JFD00715
Tox21_110165	Tox21_201565
Tox21_300292	Tox21_500614
3,4-dihydro-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide	CCG-40240
NSC757059	s1708
SBB056984	STK315354
3,2,4-benzothiadiazine-1,1-dioxide	Hydrochlorothiazide (JP17/USP/INN)
2H-1,2,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-,1,1-dioxide	AKOS000121373
Tox21_110165_1	AC-8114
DB00999	LP00614
MCULE-6585933943	NC00510
NSC-757059	PS-3162
SDCCGSBI-0050596.P005	SU-5879
IDI1_000289	WLN: T66 BSWM EM DHJ HG ISZW
NCGC00015508-01	NCGC00015508-02
NCGC00015508-03	NCGC00015508-04
NCGC00015508-05	NCGC00015508-06
NCGC00015508-07	NCGC00015508-09
NCGC00015508-10	NCGC00015508-11
NCGC00015508-12	NCGC00015508-13
NCGC00015508-14	NCGC00015508-16
NCGC00015508-17	NCGC00015508-25
NCGC00021906-03	NCGC00021906-04
NCGC00021906-05	NCGC00021906-06
NCGC00021906-07	NCGC00021906-08
NCGC00254017-01	NCGC00259114-01
NCGC00261299-01	BH164522
NCI60_004317	ST033548
component of Butizide Prestabs (Salt/Mix)	Hydrochlorothiazide 1.0 mg/ml in Methanol
SBI-0050596.P004	AB00052012
EU-0100614	FT-0650564
H1274	SW196569-3
6-Chloro-3,2,4-benzothiadiazine 1,1-dioxide	A19550
C07041	D00340
H10742	J10079
AB00052012-15	AB00052012_16
AB00052012_17	051H765
Hydrochlorothiazide 100 microg/mL in Acetonitrile	Q423930
Hydrochlorothiazide, meets USP testing specifications	Q-201210
SR-01000000119-2	SR-01000000119-4
SR-01000000119-6	BRD-K13078532-001-05-2
Z56347248	6-Chloro-3,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
6-Chloro-7-sulfamoyl-3,2,4-benzothiadiazine 1,1-dioxide	Hydrochlorothiazide, drug standard, 1.0 mg/mL in methanol
6-chloro-3,4-dihydro-1,1-dioxo-7-sulfamoyl-1,2,4-benzothiadiazine	Hydrochlorothiazide, British Pharmacopoeia (BP) Reference Standard
Hydrochlorothiazide, European Pharmacopoeia (EP) Reference Standard	3,4-Dihydro-6-chloro-7-sulfamyl-1,2, 4-benzothiadiazine-1,1-dioxide
6-chloro-3,4-dihydro-2h-1,2,4-benzothiadiazine-7-sulphonamide-1,1-dioxide	6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2, 4-benzothiadiazine 1,1-dioxide
6-Chloro-7-sulfamoyl-3, 4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide	6-Chloro-7-sulfamoyl-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide
6-Chloro-7-sulfamoyl-3,4-dihydrobenzo-1,2,4-thiadiazine-1,1-dioxide	6-Chloro-7-sulfamyl-3,4-dihydro-1,2,4-benzothiadiazine-1,1-dioxide
Hydrochlorothiazide, United States Pharmacopeia (USP) Reference Standard	2H-1,2, 4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1, 1-dioxide
2H-1,2,4-Benzothiadiazine, 6-chloro-3,4-dihydro-7-sulfamoyl-2, 1,1-dioxide	2H-1,4-Benzothiadiazine-7-sulfonamide, 6-chloro-3,4-dihydro-, 1,1-dioxide
6-chloro-1,1-dioxo-1,2,3,4-tetrahydro-1lambda,2,4-benzothiadiazine-7-sulfonamide	6-chloro-1,1-dioxo-3,4-dihydro-2H-1$l^{6,2,4-benzothiadiazine-7-sulfonamide
6-Chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1, 1-dioxide	7-(Aminosulfonyl)-6-chloro-3,4-dihydro-(2H)-1,2,4-benzothiadiazine 1,1-Dioxide
Hydrochlorothiazide for peak identification, European Pharmacopoeia (EP) Reference Standard	Hydrochlorothiazide, Pharmaceutical Secondary Standard; Certified Reference Material
125727-50-6	3,4-Dihydro-6-chloro-7-sulfamoyl-1,2,4-benzothiadiazine-1,1-dioxide; 6-Chloro-3,4-dihydro-7-sulfamoyl-2H-1,2,4-benzothiadiazine-1,1-dioxide; 3,4-Dihydrochlorothiazide
Hydrochlorothiazide solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material

Experimental Data

hydrochlorothiazide

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	33.000000000000000	umol/L			14.000000000000000				NS	N2		24134630	Inactive

Experimental Data Visualization

hydrochlorothiazide

Statistics Data

hydrochlorothiazide

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	14.000000000000000		1	1

Statistics Data Visualization

hydrochlorothiazide

Compound Name:

hydrochlorothiazide

Compound CID:

3639

Synonyms:

hydrochlorothiazide 58-93-5 HCTZ Esidrix Hypothiazide More...

Iupac Name:

6-chloro-1,1-dioxo-3,4-dihydro-2H-1lambda6,2,4-benzothiadiazine-7-sulfonamide

InChI:

InChI=1S/C7H8ClN3O4S2/c8-4-1-5-7(2-6(4)16(9,12)13)17(14,15)11-3-10-5/h1-2,10-11H,3H2,(H2,9,12,13)

InChIKey:

JZUFKLXOESDKRF-UHFFFAOYSA-N

Canonical Smiles:

C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Isomeric Smiles:

C1NC2=CC(=C(C=C2S(=O)(=O)N1)S(=O)(=O)N)Cl

Molecular Weight:

297.7

Molecular Formula:

C7H8ClN3O4S2

Molecular Weight:

297.7

Molecular Formula:

C7H8ClN3O4S2

Hydrogen Bond Donor Count:

3

Hydrogen Bond Acceptor Count:

7

Rotatable Bond Count:

1

Heavy Atom Count:

17

Complexity:

494

hydrochlorothiazide

58-93-5

HCTZ

Esidrix

Hypothiazide

Oretic

Dichlotiazid

Hidrotiazida

Hydrochlorothiazid

Hydrochlorthiazide

Hydrodiuretic

Hydrosaluric

Servithiazid

Aquarills

Aquarius

Dichlotride

Diclotride

Disalunil

Hypothiazid

Idrotiazide

Maschitt

Megadiuril

Newtolide

Thiuretic

Vetidrex

Drenol

Esidrex

Hidril

Hydril

Nefrix

Chlorosulthiadil

Hidrochlortiazid

Hydro-Diuril

Hydro-Aquil

Dihydrochlorothiazide

Jen-Diril

HydroDIURIL

Dihydrochlorothiazid

Dihydrochlorothiazidum

Apresazide

Carozide

Chlorzide

Dichlorosal

Hidroronol

Hydrothide

Hydrozide

hydrochlorothiazide

58-93-5

HCTZ

Esidrix

Hypothiazide

More...