Compound Summary
gw5074
Compound Information
gw5074
Compound Name: | gw5074 |
Compound CID: | 5924208 |
Synonyms: | gw5074 220904-83-6 GW 5074 Raf1 Kinase Inhibitor I GW-5074 More... |
Iupac Name: | (3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one |
InChI: | InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3- |
InChIKey: | LMXYVLFTZRPNRV-KMKOMSMNSA-N |
Canonical Smiles: | C1=CC2=C(C=C1I)C(=CC3=CC(=C(C(=C3)Br)O)Br)C(=O)N2 |
Isomeric Smiles: | C1=CC2=C(C=C1I)/C(=C/C3=CC(=C(C(=C3)Br)O)Br)/C(=O)N2 |
Molecular Weight: | 520.94 |
Molecular Formula: | C15H8Br2INO2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
gw5074
Molecular Weight: | 520.94 |
Molecular Formula: | C15H8Br2INO2 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 2 |
Rotatable Bond Count: | 1 |
Heavy Atom Count: | 21 |
Complexity: | 447 |
Synonyms
gw5074
| gw5074 | gw5074 |
|---|---|
gw5074 |
220904-83-6 |
GW 5074 |
Raf1 Kinase Inhibitor I |
GW-5074 |
3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one |
5-Iodo-3-(3,5-dibromo-4-hydroxyphenyl)methylene-2-indolinone |
(3Z)-3-(3,5-dibromo-4-hydroxyphenyl)methylidene-5-iodo-1H-indol-2-one |
UNII-B7W8RS1GG2 |
B7W8RS1GG2 |
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one |
CHEMBL72365 |
1233748-60-1 |
(Z)-3-(3,5-Dibromo-4-hydroxybenzylidene)-5-iodoindolin-2-one |
5-iodo-3-((3,5-dibromo-4-hydroxyphenyl)methylene)-2-indolinone |
SR-01000075897 |
STO521 |
GW5074 Z-isomer |
GW5074, powder |
Tocris-1381 |
InSolution™ Raf1 Kinase Inhibitor I |
BiomolKI_000056 |
GW-5074 Z-isomer |
Lopac-G-6416 |
BiomolKI2_000062 |
C15H8Br2INO2 |
Lopac0_000510 |
BMK1-F8 |
BSPBio_001275 |
cc-462 |
SCHEMBL149921 |
GTPL8072 |
BCBcMAP01_000125 |
DTXSID10421368 |
EX-A889 |
HMS1362O17 |
HMS1792O17 |
HMS1990O17 |
HMS3261F21 |
HMS3403O17 |
HMS3412K12 |
HMS3676K12 |
BCP06316 |
Tox21_500510 |
2453AH |
BDBM50085415 |
EI-307 |
HSCI1_000002 |
MFCD09971042 |
NSC755765 |
NSC756228 |
ZINC16052818 |
AKOS024456562 |
CCG-100660 |
CCG-221814 |
CS-0092 |
NSC-755765 |
NSC-756228 |
SDCCGSBI-0050494.P002 |
IDI1_002223 |
NCGC00015478-01 |
NCGC00015478-02 |
NCGC00015478-03 |
NCGC00015478-04 |
NCGC00015478-05 |
NCGC00015478-06 |
NCGC00015478-07 |
NCGC00015478-09 |
NCGC00015478-19 |
NCGC00025134-01 |
NCGC00025134-02 |
NCGC00025134-03 |
NCGC00025134-04 |
NCGC00025134-05 |
NCGC00025134-06 |
NCGC00261195-01 |
AC-32865 |
AS-55911 |
HY-10542 |
GW-5074, (Z)- |
G6416 (GW5074) |
EU-0100510 |
S2872 |
EC-000.2403 |
G 6416 |
K00053 |
A900890 |
J-510576 |
SR-01000075897-1 |
SR-01000075897-3 |
BRD-K07859598-001-03-9 |
Q27077947 |
UNII-P0LE4QW0S6 component LMXYVLFTZRPNRV-KMKOMSMNSA-N |
3-(3, 5-Dibromo-4-hydroxybenzylidine-5-iodo-1,3-dihydro-indol-2-one) |
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydr o-indol-2-one |
3-(3,5-dibromo-4-hydroxybenzylidene)-5-iodo-1,3-dihydroindol-2-one |
(3Z)-3-((3,5-Dibromo-4-hydroxyphenyl)methylene)-1,3-dihydro-5-iodo-2H-indol-2-one |
2H-Indol-2-one, 3-((3,5-dibromo-4-hydroxyphenyl)methylene)-1,3-dihydro-5-iodo-, (3Z)- |
3-(3,5-Dibromo-4-hydroxy-benzylidene)-5-iodo-1,3-dihydro-indol-2-one;GW5074 |
3-1-(3,5-Dibromo-4-hydroxy-phenyl)-meth-(Z)-ylidene-5-iodo-1,3-dihydro-indol-2-one |
Experimental Data
gw5074
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 2.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
gw5074
Statistics Data
gw5074
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 2.000000000000000 | 1 | 1 |
Statistics Data Visualization
gw5074
