Compound Summary
flunarizine
Compound Information
flunarizine
Compound Name: | flunarizine |
Compound CID: | 941361 |
Synonyms: | flunarizine 52468-60-7 Sibelium 1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine Flunarizinum INN-Latin More... |
Iupac Name: | 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine |
InChI: | InChI=1S/C26H26F2N2/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21/h1-15,26H,16-20H2/b7-4+ |
InChIKey: | SMANXXCATUTDDT-QPJJXVBHSA-N |
Canonical Smiles: | C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F |
Isomeric Smiles: | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F |
Molecular Weight: | 404.5 |
Molecular Formula: | C26H26F2N2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
flunarizine
Molecular Weight: | 404.5 |
Molecular Formula: | C26H26F2N2 |
Hydrogen Bond Donor Count: | 0 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 30 |
Complexity: | 487 |
Synonyms
flunarizine
| flunarizine | flunarizine |
|---|---|
flunarizine |
52468-60-7 |
Sibelium |
1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine |
Flunarizinum INN-Latin |
Flunarizina INN-Spanish |
UNII-R7PLA2DM0J |
40218-96-0 |
(E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine |
R7PLA2DM0J |
1-bis(4-fluorophenyl)methyl-4-(E)-3-phenylprop-2-enylpiperazine |
CHEMBL30008 |
(E)-1-Bis-(p-fluorophenyl)methyl-4-cinnamylpiperazine |
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, (E)- |
1-bis(4-fluorophenyl)methyl-4-(2E)-3-phenylprop-2-en-1-ylpiperazine |
Piperazine, 1-bis(4-fluorophenyl)methyl-4-(3-phenyl-2-propenyl)-, (E)- |
Flunarizine INN:BAN |
DSSTox_CID_25616 |
DSSTox_RID_81005 |
DSSTox_GSID_45616 |
Narzine |
4-((2E)-3-phenylprop-2-enyl)-1-bis(4-fluorophenyl)methylpiperazine |
Sibelium (TN) |
Flunarizine (INN) |
CAS-52468-60-7 |
EINECS 257-937-5 |
Flunarazine |
Flunarizine2HCl |
NCGC00018102-06 |
EINECS 254-842-0 |
Prestwick2_000312 |
Prestwick3_000312 |
Spectrum5_001570 |
Lopac0_000527 |
SCHEMBL43440 |
SCHEMBL43441 |
BSPBio_000304 |
BSPBio_001341 |
BSPBio_003096 |
BPBio1_000336 |
DTXSID6045616 |
BCBcMAP01_000120 |
CHEBI:92209 |
cid_6365505 |
1-bis(4-fluorophenyl)methyl-4-(E)-cinnamylpiperazine |
CHEBI:135652 |
HMS1361D03 |
HMS1791D03 |
HMS1989D03 |
HMS2089H21 |
Tox21_110825 |
BDBM50017702 |
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)- |
STL477617 |
ZINC19360739 |
1-Bis(4-fluorophenyl)methyl-4-(2E)-3-phenyl-2-propenylpiperazine |
AKOS015960783 |
Tox21_110825_1 |
AC-1283 |
CCG-204617 |
DB04841 |
SDCCGSBI-0050510.P004 |
IDI1_000043 |
IDI1_033811 |
NCGC00018102-04 |
NCGC00018102-05 |
NCGC00018102-07 |
NCGC00018102-08 |
NCGC00018102-09 |
NCGC00018102-10 |
NCGC00018102-12 |
NCGC00018102-24 |
NCGC00024308-04 |
NCGC00024308-05 |
NCGC00024308-06 |
NCGC00024308-07 |
AS-75845 |
ST024768 |
SBI-0050510.P003 |
D07971 |
D93478 |
AB00053586-15 |
AB00053586_16 |
AB00053586_17 |
118378-EP2270011A1 |
118378-EP2275420A1 |
118378-EP2280008A2 |
118378-EP2298764A1 |
118378-EP2298765A1 |
A899896 |
Q416237 |
1-bis-(4-Fluorophenyl)methyl-4-cinnamylpiperazine |
BRD-K12184470-300-01-8 |
BRD-K29582677-001-02-7 |
BRD-K29582677-300-05-6 |
BRD-K29582677-300-06-4 |
1-Bis-(4-fluoro-phenyl)-methyl-4-(3-phenyl-allyl)-piperazine |
1-Bis(4-fluorophenyl)methyl-4-(2Z)-3-phenyl-2-propen-1-ylpiperazine |
1-Bis-(4-fluoro-phenyl)-methyl-4-((E)-3-phenyl-allyl)-piperazine |
Piperazine, 1-bis(4-fluorophenyl)methyl-4-(2E)-3-phenyl-2-propenyl- |
1-Bis-(4-fluoro-phenyl)-methyl-4-(3-phenyl-allyl)-piperazine(Flunarizine) |
Experimental Data
flunarizine
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 200.000000000000000 | umol/L | 45.820000000000000 | 42.490000000000000 | -7.260000000000000 | NS | MALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 20.000000000000000 | umol/L | 49.360000000000000 | 46.070000000000000 | -6.655000000000000 | NS | FEMALES | 33008901 | Inactive |
Experimental Data Visualization
flunarizine
Statistics Data
flunarizine
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | -6.655000000000000 | 1 | 2 |
Statistics Data Visualization
flunarizine
