Compound Summary
felodipine
Compound Information
felodipine
Compound Name: | felodipine |
Compound CID: | 3333 |
Synonyms: | felodipine 72509-76-3 Plendil Flodil Renedil More... |
Iupac Name: | 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
InChI: | InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3 |
InChIKey: | RZTAMFZIAATZDJ-UHFFFAOYSA-N |
Canonical Smiles: | CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C |
Isomeric Smiles: | CCOC(=O)C1=C(NC(=C(C1C2=C(C(=CC=C2)Cl)Cl)C(=O)OC)C)C |
Molecular Weight: | 384.2 |
Molecular Formula: | C18H19Cl2NO4 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
felodipine
Molecular Weight: | 384.2 |
Molecular Formula: | C18H19Cl2NO4 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 25 |
Complexity: | 614 |
Synonyms
felodipine
| felodipine | felodipine |
|---|---|
felodipine |
72509-76-3 |
Plendil |
Flodil |
Renedil |
Feloday |
Munobal |
Splendil |
dl-Felodipine |
Perfudal |
Prevex |
Hydac |
Modip |
Agon |
Felodipina |
Felodipinum |
Felodipinum INN-Latin |
3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
Felodipina INN-Spanish |
C18H19Cl2NO4 |
Felodipine (Plendil) |
H 154/82 |
CGH-869 |
Plendil ER |
4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester |
5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
Felogard |
MFCD00868316 |
Penedil |
Preslow |
Munobal Retard |
Plendil Retard |
H-154/82 |
Plendil Depottab |
(+-)-Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate |
MLS000069629 |
CHEBI:585948 |
Felodur ER |
AGON SR |
3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate |
ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
NCGC00015455-03 |
Plandil |
SMR000058204 |
DSSTox_CID_3042 |
4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid ethyl methyl ester |
DSSTox_RID_76848 |
DSSTox_GSID_23042 |
Felodipine USAN:BAN:INN |
Logimax |
Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate |
(RS)-3-ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
Plendil (TN) |
SR-01000075890 |
BRN 4331472 |
Perfuda |
Plendil;Renedil |
Felodipine, solid |
C08CA02 |
Felodipine,(S) |
Felodipine USAN:USP:INN:BAN |
3,5-dicarboxylate |
Felodipine- Bio-X |
Prestwick_797 |
CAS-72509-76-3 |
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester |
Felodipine (dl form) |
Opera_ID_1873 |
Prestwick0_000478 |
Prestwick1_000478 |
Prestwick2_000478 |
Prestwick3_000478 |
(.+/-.)-Felodipine |
F 9677 |
CHEMBL1480 |
Lopac0_000508 |
SCHEMBL26398 |
BSPBio_000616 |
AE-641/11429675 |
MLS001077361 |
MLS001333735 |
MLS002153409 |
MLS002153832 |
MLS003876820 |
BIDD:GT0733 |
SPBio_002555 |
BPBio1_000678 |
Felodipine (JP17/USP/INN) |
GTPL4190 |
CHEMBL3196476 |
DTXSID4023042 |
SCHEMBL13460298 |
BDBM189379 |
HMS1569O18 |
HMS2089J05 |
HMS2096O18 |
HMS2232D24 |
HMS3259F12 |
HMS3261F17 |
HMS3651O21 |
HMS3713O18 |
HMS3884I14 |
Pharmakon1600-01505887 |
BCP02192 |
BCP22685 |
HY-B0309 |
2,6-dimethyl-1,4-dihydropyridine- |
Tox21_110155 |
Tox21_500508 |
CA-236 |
NSC760343 |
s1885 |
AKOS015891545 |
Tox21_110155_1 |
AC-2124 |
BCP9000680 |
CCG-204599 |
DB01023 |
KS-1264 |
LP00508 |
MCULE-8253440089 |
NC00721 |
NSC 760343 |
NSC-760343 |
SDCCGSBI-0050492.P002 |
O5-ethyl O3-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
NCGC00015455-04 |
NCGC00015455-05 |
NCGC00015455-06 |
NCGC00015455-07 |
NCGC00015455-08 |
NCGC00015455-10 |
NCGC00015455-24 |
NCGC00024087-02 |
NCGC00093906-01 |
NCGC00093906-02 |
NCGC00261193-01 |
3,5-Pyridinedicarboxylic acid, 1,4-dihydro-4-(2,3-dichlorophenyl)-2,6-dimethyl-, ethyl methyl ester |
3,5-Pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, ethyl methyl ester, (+-)- |
4-(2,3-dichloro-phenyl)-2,6-dimethyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid 3-ethyl ester 5-methyl ester |
AC-24403 |
BF164445 |
Felodipine 100 microg/mL in Acetonitrile |
K235 |
SMR002529504 |
SY053174 |
AB0014113 |
3-ethyl 5-methyl 4-(2,3-dichlorophenyl)- |
EU-0100508 |
F0814 |
FT-0626393 |
FT-0660933 |
FT-0668475 |
SW219299-1 |
EN300-70726 |
D00319 |
509F763 |
Q420644 |
SR-01000075890-1 |
SR-01000075890-4 |
BRD-A30815329-001-03-0 |
Z239864852 |
Felodipine, European Pharmacopoeia (EP) Reference Standard |
Felodipine, United States Pharmacopeia (USP) Reference Standard |
(+/-)-ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate |
(.+/-.) Ethyl methyl 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate |
3,5-pyridinedicarboxylic acid, 4-(2,3-dichlorophenyl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl-5-methylester |
3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylate # |
Ethyl methyl (4RS)-4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate |
Experimental Data
felodipine
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | -54.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
felodipine
Statistics Data
felodipine
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -54.000000000000000 | 1 | 1 |
Statistics Data Visualization
felodipine
