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Compound Summary

estradiol

Compound Information

estradiol

Compound Name:	estradiol
Compound CID:	5757
Synonyms:	estradiol beta-Estradiol 17beta-Estradiol 50-28-2 Oestradiol More...
Iupac Name:	(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol
InChI:	InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1
InChIKey:	VOXZDWNPVJITMN-ZBRFXRBCSA-N
Canonical Smiles:	CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O
Isomeric Smiles:	C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O
Molecular Weight:	272.4
Molecular Formula:	C18H24O2

Compound Structure

2D Structure:

3D Structure:

Computed Properties

estradiol

Molecular Weight:	272.4
Molecular Formula:	C18H24O2
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	2
Rotatable Bond Count:	0
Heavy Atom Count:	20
Complexity:	382

Synonyms

estradiol

estradiol	estradiol
estradiol	beta-Estradiol
17beta-Estradiol	50-28-2
Oestradiol	Dihydrofolliculin
Estrace	Ovocyclin
Vivelle	progynon
Dihydrotheelin	Dihydroxyestrin
Aquadiol	Diogynets
Gynergon	Gynoestryl
Diogyn	Oestroglandol
Aerodiol	Corpagen
Dimenformon	Estrovite
Femestral	Follicyclin
Ginosedol	Macrodiol
Oestergon	Ovahormon
Ovasterol	Ovastevol
Perlatanol	Primofol
Profoliol	Altrad
Bardiol	Climara
Divigel	Evorel
Femogen	Lamdiol
Syndiol	Vagifem
Dihydromenformon	estradiol-17beta
cis-Estradiol	Estraderm TTS
Estraderm	Estraldine
Estroclim	Trocosone
Estrogel	Menorest
Nordicol	Zumenon
Systen	D-Oestradiol
D-Estradiol	Progynon DH
Climaderm	Compudose
Dermestril	Estrasorb
Ovocycline	Encore
Estring	Menest
Oesclim	Dihydroxyoestrin
SK-Estrogens	Progynon-DH
Gynestrel	Microdiol
Oestrogynal	Ovociclina
Ovocylin	Tradelia
Estroclim 50	Innofem
Macrol	Zerella
17beta-Oestradiol	Alora
Oestradiol R	Estring vaginal ring
Dihydrofollicular hormone	Trial SAT
Theelin, dihydro-	Elestrin
Fempatch	Gynodiol
Oestrogel	Esclim
Compudose 200	Compudose 365
Profoliol B	17b-Oestradiol
17-beta-estradiol	Estradiol-17-beta
Estradot	Gelestra
3,17-Epidihydroxyestratriene	Zesteem
Dihydroxyesterin	cis-Oestradiol
Estraderm TTS 50	Estrogens, esterified
B-Estradiol	Epiestriol 50
17beta oestradiol	NSC-9895
17 beta-Estradiol	Estradiol-17 beta
Evamist	Amnestrogen
Estrogen	Femanest
Estra-1,3,5(10)-triene-3,17beta-diol	3,17-Epidihydroxyoestratriene
Sandrena 1	17b-Estradiol
(17beta)-Estra-1,3,5(10)-triene-3,17-diol	Estraderm (TN)
3H-estradiol	17\|A-estradiol
17\|A-Oestradiol	Estrogel (TN)
Climara (TN)	Divigel (TN)
Estrace (TN)	Estring (TN)
Innofem (TN)	Vagifem (TN)
Vivelle (TN)	17.beta.-Estradiol
17.beta.-Oestradiol	3,17.beta.-Estradiol
.beta.-Estradiol	(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopentaaphenanthrene-3,17-diol
.beta.-Oestradiol	3Hestradiol
UNII-4TI98Z838E	Estradiol, .beta.-
Estradiol-17.beta.	CHEBI:16469
Estra-1,3,5(10)-triene-3,17-diol (17beta)-	Oestradiol-17.beta.
ESTRADIOL HEMIHYDRATE	Oestra-1,3,5(10)-triene-3,17beta-diol
Estrasorb (TN)	17.beta.-OH-estradiol
17.beta.-OH-oestradiol	17beta estradiol (E2)
Extrasorb	17beta-Estra-1,3,5(10)-triene-3,17-diol
Estreva	Estrifam
Femtran	Ginedisc
CHEMBL135	GynPolar
(17beta)-estra-1(10),2,4-triene-3,17-diol	Sandrena Gel
D-3,17.beta.-Estradiol	D-3,17.beta.-Oestradiol
Sisare Gel	Estra-1,3,5(10)-triene-3,17-diol, (17beta)-
Estrofem 2	MLS000069494
3,17b-Dihydroxyestra-1,3,5(10)-triene	Oestradiolum
Climara Forte	4TI98Z838E
Oestradiol Berco	Estraderm MX
VIVELLE-DOT	1,3,5-Estratriene-3,17beta-diol
3HE2	Oestradiol-17beta
Estrapak 50	(1S,10R,11S,14S,15S)-15-methyltetracyclo8.7.0.0^{2,7}.0^{11,15}heptadeca-2(7),3,5-triene-5,14-diol
141290-02-0	Estradiolum INN
Estradiolo DCIT	NCGC00091544-04
Oestradiol-17-beta	Estradiolum
Estrodiolum	Estradiolo
Femestrol	SMR000059126
Estradiol-3,17beta	DSSTox_CID_573
17-beta-OH-estradiol	3,17-beta-Estradiol
3,17beta-Dihydroxy-1,3,5(10)-estratriene	3,17beta-Dihydroxyestra-1,3,5(10)-triene
3,17-beta-Oestradiol	D-3,17beta-Estradiol
E(sub 2)	DSSTox_RID_75666
Methyl 1-cyclopropyl-6,7-difluoro-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylate.	Benzogynestry
DSSTox_GSID_20573	Estropause
Estasorb	(8R,9S,13S,14S,17S)-13-Methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopentaaphenanthrene-3,17-diol
2,4,6,7-3H-E2	E 2
E2	Destradiol
Minivelle	Yuvvexy
Zesteen	17-beta-OH-oestradiol
D-3,17beta-Oestradiol	D-3,17-beta-Estradiol
Estrodiolum INN-Latin	NSC-20293
D-3,17-beta-Oestradiol	Activella (Salt/Mix)
Combipatch (Salt/Mix)	CCRIS 280
component of Menrium	Estradiol-17 alpha
Climara Pro (Salt/Mix)	3,17beta-Estradiol
3,17-.beta.-Oestradiol	Estraderm TTS 100
HSDB 3589	3,3,5(10)-triene
SR-01000075866	17-.BETA.-Estradiol
EINECS 200-023-8	Estra-1,3,5(10)-triene-3,17-diol (17.beta.)-
(+)-3,17.beta.-Estradiol	1,3,5-Estratriene-3,17-beta-diol
oestrodiol	Estradiol USP:INN:BAN
3,17beta-Dihydroxyestra-1,3,5-triene	3,17beta-Dihydroxyoestra-1,3,5-triene
Elestrim	delta-Estradiol
dihydro-Theelin	3,17-beta-Dihydroxyoestra-1,3,5-triene
delta-Oestradiol	TX-004HR
MFCD00003693	Estra-1,3,5(10)-triene-3,17-beta-diol
Estradiol complex	Estrogel HBF
Oestra-1,3,5(10)-triene-3,17-beta-diol	1jgl
1lhu	1qkt
1qku	3,17-beta-Dihydroxyestra-1,3,5(10)-triene
3Hestradiol	1,3,5-Estratriene-3,17.beta.-diol
3,17-beta-Dihydroxy-1,3,5(10)-oestratriene	CAS-50-28-2
17-beta-Estra-1,3,5(10)-triene-3,17-diol	17beta-Oestra-1,3,5(10)-triene-3,17-diol
.alpha.-Oestradiol	17-beta-Oestra-1,3,5(10)-triene-3,17-diol
Estra-1,3,5(10)-triene-3,17-diol	Prestwick_207
3,17b-Estradiol	Bio-E-Gel
Fem7	3H-Estrogen
17 ?-Estradiol	3,17.beta.-Dihydroxyestra-1,3,5-triene
3,17.beta.-Dihydroxyoestra-1,3,5-triene	CMC_11154
1,3,5,(10)-Estratrien-3,17.beta.-diol	SL-1100
Estra-1,3,5(10)-triene-3,17.beta.-diol	Oestra-1,3,5(10)-triene-3,17.beta.-diol
2j7x	3,17.beta.-Dihydroxy-1,3,5(10)-estratriene
3,17.beta.-Dihydroxy-1,3,5(10)-oestratriene	3,17.beta.-Dihydroxyestra-1,3,5(10)-triene
3,3,5-triene	3H17beta-estradiol
(17?)-Estra-1,3,5(10)-triene-3,17-diol	17.beta.-Estra-1,3,5(10)-triene-3,17-diol
17.beta.-Oestra-1,3,5(10)-triene-3,17-diol	Opera_ID_1688
Prestwick0_000441	Prestwick1_000441
Prestwick2_000441	Prestwick3_000441
Spectrum5_002055	17beta-estradiol (E2)
alpha-estradiol (obsolete)	beta-Estradiol, >=98%
bmse000642	Epitope ID:136018
(+)-3,17b-Estradiol	E 8875
EC 200-023-8	SCHEMBL8049
(+)-3,17beta-Estradiol	Estradiol (JAN/USP/INN)
Tritiated estradiol-17-beta	BIDD:PXR0065
Lopac0_000503	S-21400
BSPBio_000482	BSPBio_001065
KBioGR_000405	KBioGR_002269
KBioSS_000405	KBioSS_002270
Oestradiol-17beta and esters	MLS000758312
MLS001076331	MLS001424022
BIDD:ER0125	Oestradiol-17beta and esters Steroidal oestrogens
SPBio_002421	BPBio1_000532
GTPL1012	GTPL1013
DTXSID0020573	NIOSH/KG7030000
BDBM17292	KBio2_000405
KBio2_002269	KBio2_002973
KBio2_004837	KBio2_005541
KBio2_007405	KBio3_000769
KBio3_000770	KBio3_002749
AOB5963	NSC9895
1a52	1g50
2d06	cMAP_000005
Bio1_000403	Bio1_000892
Bio1_001381	Bio2_000363
Bio2_000843	HMS1362E07
HMS1569I04	HMS1792E07
HMS1990E07	HMS2051C17
HMS2090E18	HMS2096I04
HMS2236H04	HMS3261F07
HMS3403E07	HMS3713I04
HMS3884A08	beta-Estradiol, analytical standard
ACN-S003579	BCP08579
HY-B0141	Tox21_111148
Tox21_202057	Tox21_300288
Tox21_500503	1,5-Estratriene-3,17.beta.-diol
LMST02010001	s1709
WC3011	ZINC13520815
Estradiol-17-beta-6,7-(sup 3)H	2,4,6,7-3H-17beta-estradiol
AKOS015896570	CCG-100808
CS-1938	DB00783
LP00503	NC00058
SDCCGSBI-0050487.P002	WC-3011
IDI1_002118	SMP1_000121
NCGC00091544-00	NCGC00091544-01
NCGC00091544-02	NCGC00091544-05
NCGC00091544-06	NCGC00091544-07
NCGC00091544-09	NCGC00091544-10
NCGC00091544-11	NCGC00091544-12
NCGC00091544-13	NCGC00091544-14
NCGC00091544-15	NCGC00091544-16
NCGC00091544-18	NCGC00091544-27
NCGC00179321-01	NCGC00179321-02
NCGC00254177-01	NCGC00259606-01
NCGC00261188-01	17-E
AC-22346	AS-13729
CPD000059126	Estra-1,3,5(10)-triene-3,17b-diol
Oestra-1,3,5(10)-triene-3,17b-diol	WLN: L E5 B666TTT&J E1 FQ OQ
AB0012866	Estra-1,5(10)-triene-3,17.beta.-diol
Estradiol, meets USP testing specifications	3,17beta-dihydroxyestra-1,3,5(10)-trien
EU-0100503	KG70300000
Oestra-1,5(10)-triene-3,17.beta.-diol	C00951
D00105	J10189
(17b)-Estra-1,3,5(10)-triene-3,17-diol	13b-Methyl-1,3,5(10)-gonatriene-3,17b-ol
17-decahydrocyclopentaaphenanthrene-3,17-diol	17.beta.-Estra-1,5(10)-triene-3,17-diol
17.beta.-Oestra-1,5(10)-triene-3,17-diol	003E693
17-beta-Estradiol 100 microg/mL in Acetonitrile	Q422416
SR-01000721892	13beta-Methyl-1,3,5(10)-gonatriene-3,17beta-ol
Estra-1,5(10)-triene-3,17-diol (17.beta.)-	Q-201503
SR-01000075866-1	SR-01000075866-4
SR-01000721892-3	BRD-K18910433-001-04-4
BRD-K18910433-001-43-2	estra-1(10),2,4-triene-3,17-diol, (17beta)-
Estra-1,5(10)-triene-3,17-diol, (17.beta.)-	Z1847670481
B8B5AEF5-4957-49EB-A14F-444A8212C482	beta-Estradiol, BioReagent, powder, suitable for cell culture
Estradiol, United States Pharmacopeia (USP) Reference Standard	beta-Estradiol, powder, gamma-irradiated, suitable for cell culture
Estra-1,3,5(10)-triene-3,17-diol, (6,7-(sup 3)H,17-beta)-	(9beta,13alpha,14beta,17alpha)-estra-1,3,5(10)-triene-3,17-diol
Estradiol, Pharmaceutical Secondary Standard; Certified Reference Material	(13S,17S)-13-methyl-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopentaaphenanthrene-3,17-beta-diol
(1S,10R,11S,14S,15S)-15-methyltetracyclo8.7.0.0;{2,7}.0;{11,15}heptadeca-2,4,6-triene-5,14-diol	(8S,9S,13S,14S,17S)-13-Methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopentaaphenanthrene-3,17-diol
17beta-Estradiol solution, 1.0 mg/mL in acetonitrile, ampule of 1 mL, certified reference material

Experimental Data

estradiol

Species	Dose	Unit	Avg/Med Lifespan Change(%)	Significant	Strain	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	50.000000000000000	umol/L	9.770000000000000	NS	N2	30970250	Inactive
Caenorhabditis elegans	33.000000000000000	umol/L	7.000000000000000	S	N2	24134630	Active
Caenorhabditis elegans	33.000000000000000	umol/L	7.000000000000000	S	N2	33683565	Active

Experimental Data Visualization

estradiol

Statistics Data

estradiol

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	9.770000000000000		3	3

Statistics Data Visualization

estradiol

Compound Name:

estradiol

Compound CID:

5757

Synonyms:

estradiol beta-Estradiol 17beta-Estradiol 50-28-2 Oestradiol More...

Iupac Name:

(8R,9S,13S,14S,17S)-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthrene-3,17-diol

InChI:

InChI=1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17+,18+/m1/s1

InChIKey:

VOXZDWNPVJITMN-ZBRFXRBCSA-N

Canonical Smiles:

CC12CCC3C(C1CCC2O)CCC4=C3C=CC(=C4)O

Isomeric Smiles:

C[C@]12CC[C@H]3[C@H]([C@@H]1CC[C@@H]2O)CCC4=C3C=CC(=C4)O

Molecular Weight:

272.4

Molecular Formula:

C18H24O2

Molecular Weight:

272.4

Molecular Formula:

C18H24O2

Hydrogen Bond Donor Count:

2

Hydrogen Bond Acceptor Count:

2

Rotatable Bond Count:

0

Heavy Atom Count:

20

Complexity:

382

estradiol

beta-Estradiol

17beta-Estradiol

50-28-2

Oestradiol

Dihydrofolliculin

Estrace

Ovocyclin

Vivelle

progynon

Dihydrotheelin

Dihydroxyestrin

Aquadiol

Diogynets

Gynergon

Gynoestryl

Diogyn

Oestroglandol

Aerodiol

Corpagen

Dimenformon

Estrovite

Femestral

Follicyclin

Ginosedol

Macrodiol

Oestergon

Ovahormon

Ovasterol

Ovastevol

Perlatanol

Primofol

Profoliol

Altrad

Bardiol

Climara

Divigel

Evorel

Femogen

Lamdiol

Syndiol

Vagifem

Dihydromenformon

estradiol-17beta

cis-Estradiol

Estraderm TTS

estradiol

beta-Estradiol

17beta-Estradiol

50-28-2

Oestradiol

More...