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Compound Summary

cortisone

Compound Information

cortisone

Compound Name:	cortisone
Compound CID:	222786
Synonyms:	cortisone 53-06-5 Kendalls compound E Andreson Cortisal More...
Iupac Name:	(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione
InChI:	InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1
InChIKey:	MFYSYFVPBJMHGN-ZPOLXVRWSA-N
Canonical Smiles:	CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C
Isomeric Smiles:	C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C
Molecular Weight:	360.4
Molecular Formula:	C21H28O5

Compound Structure

2D Structure:

3D Structure:

Computed Properties

cortisone

Molecular Weight:	360.4
Molecular Formula:	C21H28O5
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	5
Rotatable Bond Count:	2
Heavy Atom Count:	26
Complexity:	724

Synonyms

cortisone

cortisone	cortisone
cortisone	53-06-5
Kendalls compound E	Andreson
Cortisal	Cortisate
Cortistal	Cortivite
Cortogen	Cortone
Reichsteins substance FA	Adrenalex
Reichstein Fa	Wintersteiners compound F
11-Dehydro-17-hydroxycorticosterone	17-Hydroxy-11-dehydrocorticosterone
Cortandren	Cortisona
Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-	4-Pregnene-17alpha,21-diol-3,11,20-trione
Cortison	Kortison
17alpha-Hydroxy-11-dehydrocorticosterone	17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione
NSC 9703	Kendalls compound
17,21-Dihydroxypregn-4-ene-3,11,20-trione	3H-cortisone
Prestwick_132	UNII-V27W9254FZ
Pregn-4-en-17alpha,21-diol-3,11,20-trione	17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione
KE	delta(sup4)-pregnene-17alpha,21-diol-3,11,20-trione
MLS000028540	CHEBI:16962
3Hcortisone	NSC9703
V27W9254FZ	MFCD00003610
(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopentaaphenanthrene-3,11-dione	SMR000058334
17.alpha.-Hydroxy-11-dehydrocorticosterone	DSSTox_CID_2857
DSSTox_RID_76760	DSSTox_GSID_22857
Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy	Cortisonum
Cortisone INN:BAN	Cortisonum INN-Latin
Cortisona INN-Spanish	(1S,2R,10S,11S,14R,15S)-14-hydroxy-14-(2-hydroxyacetyl)-2,15-dimethyltetracyclo8.7.0.0^{2,7}.0^{11,15}heptadec-6-ene-5,17-dione
EINECS 200-162-4	AI3-52938
CAS-53-06-5	Cortisone (TN)
Cortisone (INN)	NCGC00095935-01
Kendalls Compound E	Corlin (Salt/Mix)
Cortelan (Salt/Mix)	Ricortex (Salt/Mix)
(non-d)Cortisone-d2	Cortadren (Salt/Mix)
Scheroson (Salt/Mix)	Cortisone, >=98%
Opera_ID_541	Reichsteins Substance Fa
Prestwick0_000273	Prestwick1_000273
Prestwick2_000273	Prestwick3_000273
Spectrum5_002051	bmse000663
SCHEMBL4888	CHEMBL1499
Lopac0_000240	BSPBio_000146
MLS001076142	MLS001424269
MLS002207137	17.alpha.,11,20-trione
SPBio_002365	BPBio1_000162
GTPL5171	DTXSID5022857
BDBM13739	Cortisone 0.1 mg/ml in Methanol
HMS1568H08	HMS2052A21
HMS2095H08	HMS2235P19
HMS3260P21	HMS3712H08
ZINC4083557	Tox21_111539
Tox21_301440	Tox21_500240
LMST02030090	s5869
AKOS015840096	AKOS015894868
Tox21_111539_1	ACN-053277
CCG-101143	CS-5097
DB14681	LP00240
NC00393	SDCCGSBI-0050228.P002
4-Pregnene-17.alpha.,11,20-trione	NCGC00023939-03
NCGC00023939-04	NCGC00023939-05
NCGC00023939-06	NCGC00023939-07
NCGC00023939-08	NCGC00023939-09
NCGC00023939-11	NCGC00023939-15
NCGC00255108-01	NCGC00260925-01
Pregn-4-en-17.alpha.,11,20-trione	AC-33118
AS-11686	HY-17461
NCI60_042165	EU-0100240
2708-EP2269977A2	2708-EP2272834A1
2708-EP2292228A1	2708-EP2295411A1
2708-EP2298747A1	2708-EP2301929A1
2708-EP2301935A1	2708-EP2305674A1
2708-EP2308851A1	2708-EP2311811A1
2708-EP2314585A1	C 2755
C00762	D07749
D96089	Pregn-4-ene-3,20-trione, 17,21-dihydroxy-
10841-EP2280008A2	10841-EP2298767A1
10841-EP2301536A1	10841-EP2301538A1
10841-EP2311455A1	10841-EP2314587A1
10841-EP2316452A1	.delta.(sup4)-pregnene-17.alpha.,11,20-trione
17??,21-Dihydroxypregn-4-ene-3,11,20-trione	4-Pregnene-17.alpha.,21-diol-3,11,20-trione
Q423185	SR-01000000094
Pregn-4-en-17.alpha.,21-diol-3,11,20-trione	SR-01000000094-3
W-105776	17.alpha.,21-Dihydroxy-4-pregnene-3,11,20-trione
BRD-K43736954-001-03-3	Cortisone, certified reference material, TraceCERT(R)
Delta(4)-pregnene-17alpha,21-diol-3,11,20-trione	WLN: L E5 B666 CV OV MUTJ A1 E1 FV1Q FQ
.DELTA.4-pregnene-17.alpha.,21-diol-3,11,20-trione	17.alpha.,21.beta.-Dihydroxypregn-4-ene-3,11,20-trione
(10R,13S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopentaaphenanthrene-3,11-dione	Kendalls Compound E; 4-Pregnene-17alpha,21-diol-3,11,20-trione; Reichsteins Substance Fa"

Experimental Data

cortisone

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Significant	Strain	PubMed	Avg/Med Lifespan Change tab
Asplanchna brightwellii	50.000000000000000	umol/L	5.380000000000000	5.500000000000000	2.200000000000000	Unclear	clone 4B61	2782995
Asplanchna brightwellii	10.000000000000000	umol/L	5.380000000000000	5.420000000000000	0.700000000000000	Unclear	clone 4B61	2782995
Asplanchna brightwellii	400.000000000000000	umol/L	5.380000000000000	5.210000000000000	-3.100000000000000	Unclear	clone 4B61	2782995	Inactive
Asplanchna brightwellii	800.000000000000000	umol/L	5.380000000000000	5.040000000000000	-6.300000000000000	Unclear	clone 4B61	2782995	Inactive
Asplanchna brightwellii	100.000000000000000	umol/L	5.380000000000000	6.500000000000000	20.800000000000000	Unclear	clone 4B61	2782995
Asplanchna brightwellii	200.000000000000000	umol/L	5.380000000000000	6.420000000000000	19.300000000000000	Unclear	clone 4B61	2782995
Caenorhabditis elegans	33.000000000000000	umol/L			-2.000000000000000	NS	N2	24134630	Inactive

Experimental Data Visualization

cortisone

Statistics Data

cortisone

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Asplanchna brightwellii	20.800000000000000		1	6
Caenorhabditis elegans	-2.000000000000000		1	1

Statistics Data Visualization

cortisone

Compound Name:

cortisone

Compound CID:

222786

Synonyms:

cortisone 53-06-5 Kendalls compound E Andreson Cortisal More...

Iupac Name:

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopenta[a]phenanthrene-3,11-dione

InChI:

InChI=1S/C21H28O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-15,18,22,26H,3-8,10-11H2,1-2H3/t14-,15-,18+,19-,20-,21-/m0/s1

InChIKey:

MFYSYFVPBJMHGN-ZPOLXVRWSA-N

Canonical Smiles:

CC12CCC(=O)C=C1CCC3C2C(=O)CC4(C3CCC4(C(=O)CO)O)C

Isomeric Smiles:

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2C(=O)C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C

Molecular Weight:

360.4

Molecular Formula:

C21H28O5

Molecular Weight:

360.4

Molecular Formula:

C21H28O5

Hydrogen Bond Donor Count:

2

Hydrogen Bond Acceptor Count:

5

Rotatable Bond Count:

2

Heavy Atom Count:

26

Complexity:

724

cortisone

53-06-5

Kendalls compound E

Andreson

Cortisal

Cortisate

Cortistal

Cortivite

Cortogen

Cortone

Reichsteins substance FA

Adrenalex

Reichstein Fa

Wintersteiners compound F

11-Dehydro-17-hydroxycorticosterone

17-Hydroxy-11-dehydrocorticosterone

Cortandren

Cortisona

Pregn-4-ene-3,11,20-trione, 17,21-dihydroxy-

4-Pregnene-17alpha,21-diol-3,11,20-trione

Cortison

Kortison

17alpha-Hydroxy-11-dehydrocorticosterone

17alpha,21-Dihydroxypregn-4-ene-3,11,20-trione

NSC 9703

Kendalls compound

17,21-Dihydroxypregn-4-ene-3,11,20-trione

3H-cortisone

Prestwick_132

UNII-V27W9254FZ

Pregn-4-en-17alpha,21-diol-3,11,20-trione

17alpha,21-Dihydroxy-4-pregnene-3,11,20-trione

KE

delta(sup4)-pregnene-17alpha,21-diol-3,11,20-trione

MLS000028540

CHEBI:16962

3Hcortisone

NSC9703

V27W9254FZ

MFCD00003610

(8S,9S,10R,13S,14S,17R)-17-hydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,9,12,14,15,16-decahydrocyclopentaaphenanthrene-3,11-dione

SMR000058334

17.alpha.-Hydroxy-11-dehydrocorticosterone

DSSTox_CID_2857

DSSTox_RID_76760

DSSTox_GSID_22857

cortisone

53-06-5

Kendalls compound E

Andreson

Cortisal

More...