Compound Summary

colchicine
  Compound Information
 colchicine

Compound Name:

colchicine

Compound CID:

6167

Synonyms:

colchicine

64-86-8

Colchicin

Colchisol

Colcin

More...

Iupac Name:

N-[(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl]acetamide

InChI:

InChI=1S/C22H25NO6/c1-12(24)23-16-8-6-13-10-19(27-3)21(28-4)22(29-5)20(13)14-7-9-18(26-2)17(25)11-15(14)16/h7,9-11,16H,6,8H2,1-5H3,(H,23,24)/t16-/m0/s1

InChIKey:

IAKHMKGGTNLKSZ-INIZCTEOSA-N

Canonical Smiles:

CC(=O)NC1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Isomeric Smiles:

CC(=O)N[C@H]1CCC2=CC(=C(C(=C2C3=CC=C(C(=O)C=C13)OC)OC)OC)OC

Molecular Weight:

399.4

Molecular Formula:

C22H25NO6

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 colchicine

Molecular Weight:

399.4

Molecular Formula:

C22H25NO6

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

6

Rotatable Bond Count:

5

Heavy Atom Count:

29

Complexity:

740

  Synonyms
 colchicine

colchicine colchicine

colchicine

64-86-8

Colchicin

Colchisol

Colcin

Colchicina

Condylon

Colchineos

Colsaloid

Colchicinum

Colcrys

7alphaH-Colchicine

Kolkicin

Goutnil

(S)-colchicine

Mitigare

spindle poison

NSC 757

UNII-SML2Y3J35T

(S)-N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoaheptalen-7-yl)acetamide

N-(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzoaheptalen-7-ylacetamide

N-Acetyl trimethylcolchicinic acid methylether

NSC757

N-(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzoaheptalen-7-ylacetamide

MFCD00078484

CHEMBL107

SML2Y3J35T

CHEBI:27882

NSC-757

Colchicin German

NCGC00025125-07

Colchysat

Colchicina Italian

7-alpha-H-Colchicine

DSSTox_CID_4845

DSSTox_RID_77551

DSSTox_GSID_24845

Colstat

Acetamide, N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-

Acetamide, N-(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoaheptalen-7-yl-

Colchicine (TN)

N-(7s)-1,2,3,10-Tetramethoxy-9-Oxo-6,7-Dihydro-5h-Benzodheptalen-7-Ylethanamide

30512-31-3

LOC

SMR000058323

CCRIS 691

Colchicine, Colchicum autumnale

7.alpha.H-Colchicine

HSDB 3044

Acetamide, N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)-, (S)-

Colchicine USP:JAN

SR-01000075794

SR-01000597576

EINECS 200-598-5

AI3-31149

(S)-colchicina

4lzr

(S)-colchicin

Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(.alpha.)heptalen-7-yl)-

Acetamide,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo.alpha.heptalen-7-yl)-

MPC-004

N-((7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)- acetamide

CAS-64-86-8

(-)-colchicine

Prestwick_695

N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo(a)heptalen-7-yl)acetamide

Spectrum_000842

Tocris-1364

4o2b

Prestwick0_000363

Prestwick1_000363

Prestwick2_000363

Prestwick3_000363

Spectrum2_000075

Spectrum3_000362

Spectrum4_000298

Spectrum5_000787

Colchicine (JP17/USP)

UPCMLD-DP065

Benzo(a)heptalen-9(5H)-one, 7-acetamido-6,7-dihydro-1,2,3,10-tetramethoxy-

C 9754

EC 200-598-5

SCHEMBL8469

N-(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoaheptalen-7-ylacetamide

Lopac0_000310

methoxylated analogue of XD1

BSPBio_000485

BSPBio_002083

KBioGR_000856

KBioSS_001322

MLS001055448

MLS001304089

MLS002153786

DivK1c_000753

SPECTRUM1500205

SPBio_000289

SPBio_002406

BPBio1_000535

GTPL2367

MEGxp0_001879

DTXSID5024845

UPCMLD-DP065:001

ACon1_000353

HMS502F15

KBio1_000753

KBio2_001322

KBio2_003890

KBio2_006458

KBio3_001303

NINDS_000753

HMS1569I07

HMS1920A08

HMS2091G16

HMS2096I07

HMS2231C05

HMS3260N22

HMS3713I07

Pharmakon1600-01500205

ZINC621853

Colchicine, >=96.0% (HPLC)

Tox21_110947

Tox21_201547

Tox21_300582

Tox21_500310

BDBM50014846

CCG-39910

NSC756702

s2284

AKOS001582887

Colchicine, >=95% (HPLC), powder

Tox21_110947_1

CS-1141

DB08117

EBD2156734

LP00310

MCULE-1568647156

MCULE-7858118731

NSC-756702

SDCCGMLS-0066633.P001

SDCCGSBI-0050298.P006

IDI1_000753

N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo.alpha.heptalen-7-yl)-acetamide

NCGC00025125-01

NCGC00025125-02

NCGC00025125-03

NCGC00025125-04

NCGC00025125-05

NCGC00025125-06

NCGC00025125-08

NCGC00025125-09

NCGC00025125-10

NCGC00025125-11

NCGC00025125-12

NCGC00025125-13

NCGC00025125-14

NCGC00025125-15

NCGC00025125-18

NCGC00025125-20

NCGC00025125-33

NCGC00169157-01

NCGC00169157-02

NCGC00169157-03

NCGC00254359-01

NCGC00259096-01

NCGC00260995-01

AS-13686

HY-16569

NCI60_041659

SBI-0050298.P004

A3324

EU-0100310

FT-0603187

MLS001055448-02

N1721

C-7100

C07592

D00570

J10109

M01514

24218-EP2275412A1

24218-EP2277865A1

24218-EP2281815A1

24218-EP2301933A1

24218-EP2301940A1

24218-EP2305219A1

24218-EP2305640A2

24218-EP2311827A1

24218-EP2314590A1

binds to tubulin; inhibits microtubular assembly

078C484

Colchicine (contains 5% Ethyl Acetate at maximum)

SR-01000075794-1

SR-01000075794-3

SR-01000075794-6

SR-01000075794-7

SR-01000597576-1

SR-01000597576-3

BRD-K00259736-001-06-5

BRD-K00259736-001-10-7

WLN: L B677 MV&T&J CO1 DO1 EO1 JMV1 NO1

Benzoaheptalen-9(5H)-one,7-dihydro-1,2,3,10-tetramethoxy-

Colchicine, (European Pharmacopoeia (EP) Reference Standard)

Colchicine, United States Pharmacopeia (USP) Reference Standard

Colchicine, BioReagent, plant cell culture tested, >=95% (HPLC)

Colchicine, Pharmaceutical Secondary Standard; Certified Reference Material

(S)-N-(5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoaheptalen-7-yl) acetamide

Colchicine for system suitability, European Pharmacopoeia (EP) Reference Standard

N-(5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzoa-heptalen-7-yl)-acetamid

N-(7S)-1,2,3,10-tetramethoxy-9-oxo-5,6,7,9-tetrahydrobenzoaheptalen-7-ylacetamide;

N-(7S)-1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzodheptalen-7-ylacetamide
  Experimental Data
 colchicine

Species Dose Unit Control(Avg days) Treatment(Avg days) Avg/Med Lifespan Change(%) Control(Max days) Treatment(Max days) Max Lifespan Change(%) Significant Strain Gender PubMed Avg/Med Lifespan Change tab
Caenorhabditis elegans 33.000000000000000 umol/L -7.000000000000000 NS N2 24134630 Inactive
  Experimental Data Visualization
 colchicine

  Statistics Data
 colchicine

Species Avg/Med Lifespan Change(%) Max Lifespan Change(%) Count Reference Count Data point
Caenorhabditis elegans -7.000000000000000 1 1
  Statistics Data Visualization
 colchicine

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