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Compound Summary

camptothecin

Compound Information

camptothecin

Compound Name:	camptothecin
Compound CID:	24360
Synonyms:	camptothecin Camptothecine 7689-03-4 (S)-(+)-Camptothecin Campathecin More...
Iupac Name:	(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
InChI:	InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1
InChIKey:	VSJKWCGYPAHWDS-FQEVSTJZSA-N
Canonical Smiles:	CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
Isomeric Smiles:	CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O
Molecular Weight:	348.4
Molecular Formula:	C20H16N2O4

Compound Structure

2D Structure:

3D Structure:

Computed Properties

camptothecin

Molecular Weight:	348.4
Molecular Formula:	C20H16N2O4
Hydrogen Bond Donor Count:	1
Hydrogen Bond Acceptor Count:	5
Rotatable Bond Count:	1
Heavy Atom Count:	26
Complexity:	742

Synonyms

camptothecin

camptothecin	camptothecin
camptothecin	Camptothecine
7689-03-4	(S)-(+)-Camptothecin
Campathecin	(+)-Camptothecine
d-Camptothecin	(+)-Camptothecin
20(S)-Camptothecine	21,22-Secocamptothecin-21-oic acid lactone
NSC94600	Camptothecine (8CI)
Camptothecine (S,+)	CHEMBL65
(4S)-4-ethyl-4-hydroxy-1H-pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione	UNII-XT3Z54Z28A
(S)-4-ethyl-4-hydroxy-1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione	MLS000766223
XT3Z54Z28A	CHEBI:27656
MFCD00081076	NSC-94600
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo11.8.0.02,11.04,9.015,20henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione	251316-95-7
(S)-Camptothecin	(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo11.8.0.0^{2,11}.0^{4,9}.0^{15,20}henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione
1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-	20(S)-Camptothecin
4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZOB,HFLUORENE-3,13-DIONE	SR-01000075798
SR-01000597379	d-camptothecine
(s)-camptothecine	Camptothecin, Camptotheca acuminata
Camptothecin,(S)	( )-Camptothecin
(S)-4-ethyl-4-hydroxy-1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione"	(S)-4-Ethyl-4-hydroxy-1H-pyrano3,4:6,7indolizino1,2-bquinoline-3,14-(4H,12H)-dione"
1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-"	1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-"
1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-	Prestwick_102
(+)-Camptothecin;	Spectrum_000299
Tocris-1100	SpecPlus_000712
Prestwick0_000200	Prestwick1_000200
Prestwick2_000200	Prestwick3_000200
Spectrum2_000903	Spectrum3_001203
Spectrum4_000738	Spectrum5_001126
Lopac-C-9911	SCHEMBL6038
Lopac0_000341	BSPBio_000159
BSPBio_002586	KBioGR_001036
KBioSS_000779	KBioSS_002283
cid_24360	DivK1c_000826
DivK1c_006808	SPECTRUM1502232
SPBio_000746	SPBio_002080
BPBio1_000175	CCRIS 8162
DTXSID0030956	HMS502J08
KBio1_000826	KBio1_001752
KBio2_000779	KBio2_003347
KBio2_005915	KBio3_002086
4-Ethyl-4-hydroxy-1H-pyrano-3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione	NINDS_000826
Bio1_000400	Bio1_000889
Bio1_001378	HMS1568H21
HMS1921N08	HMS2089F08
HMS2095H21	HMS3261E03
HMS3414J17	HMS3654D13
HMS3678J15	HMS3712H21
ZINC105309	(S)-4-Ethyl-4-hydroxy-1H-pyrano-3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione
ACT02668	BCP02857
Tox21_500341	AC-202
BBL033963	BDBM50008923
CCG-40255	GR-301
NSC 94600	s1288
STK801886	AKOS004119861
CS-1049	DB04690
KS-5235	LP00341
MCULE-1654983682	SDCCGMLS-0066688.P001
SDCCGSBI-0050329.P003	BRN 0631069
CAS-2114454	IDI1_000826
NCGC00015290-01	NCGC00016994-01
NCGC00016994-02	NCGC00016994-03
NCGC00016994-04	NCGC00016994-05
NCGC00016994-06	NCGC00016994-07
NCGC00016994-08	NCGC00016994-09
NCGC00016994-10	NCGC00016994-11
NCGC00016994-12	NCGC00016994-16
NCGC00016994-29	NCGC00024997-01
NCGC00024997-02	NCGC00024997-03
NCGC00024997-04	NCGC00024997-05
NCGC00024997-06	NCGC00178592-01
NCGC00178592-02	NCGC00261026-01
4-Ethyl-4-hydroxy-1H-pyrano3′,4′:6,7indolizino1,2-bquinoline-3,14(4H,12H)dione	HY-16560
K332	NCI60_042105
SMR000445686	SY010324
AI3-62475	EU-0100341
N1868	SW196414-3
C 9911	C01897
J10012	M01564
32320-EP2270008A1	32320-EP2272827A1
32320-EP2275420A1	32320-EP2277507A1
32320-EP2277865A1	32320-EP2280013A1
32320-EP2281815A1	32320-EP2286795A1
32320-EP2286812A1	32320-EP2289892A1
32320-EP2292615A1	32320-EP2292617A1
32320-EP2295055A2	32320-EP2295416A2
32320-EP2298748A2	32320-EP2298764A1
32320-EP2298765A1	32320-EP2298778A1
32320-EP2301933A1	32320-EP2305640A2
32320-EP2305642A2	32320-EP2305671A1
32320-EP2308855A1	32320-EP2311453A1
32320-EP2311827A1	32320-EP2311840A1
AB00052452-08	AB00052452-09
AB00052452_10	(S)-(+)-Camptothecin, >=90% (HPLC), powder
157594-EP2277507A1	157594-EP2286795A1
179002-EP2280013A1	689C034
A838882	Q419964
Q-200785	SR-01000075798-1
SR-01000075798-4	SR-01000597379-1
SR-01000597379-3	BRD-K37890730-001-09-4
BRD-K37890730-001-10-2	(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzob,hflorene-3,13-dione
(S)-4-ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzob,hfluorene-3,13-dione	4-Ethyl-4-hydroxy-1H-pyrano-3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione
Topotecan Related Compound C, United States Pharmacopeia (USP) Reference Standard	(S)-4-Ethyl-4-hydroxy-1H-pyrano-3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione;(S)-(+)-Camptothecin
(S)-4-Ethyl-4-hydroxy-1H-pyrano3 inverted exclamation mark ,4 inverted exclamation mark :6,7indolizino1,2-bquinoline-3,14-(4H,12H)-dione	1H-Pyrano3,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-"
4(S)-Ethyl-4-hydroxy-1H-pyrano-3,4:6,7indolizino1,2-bquinoline-3,14 (4H,12H)-dione"	4-ethyl-4-hydroxy-(4S)-3,4,12,14-tetrahydro-1H-pyrano3,4:6,7indolizino1,2-bquinoline-3,14-dione
4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzob,hfluorene-3,13-dione (camptothecin or CPT)	4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzob,hfluorene-3,13-dione (Camptothecin)
4-Ethyl-4-hydroxy-1,12-dihydro-4H-2-oxa-6,12a-diaza-dibenzob,hfluorene-3,13-dione (CPT, Camptothecin)

Experimental Data

camptothecin

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	33.000000000000000	umol/L			8.000000000000000				NS	N2		24134630	Inactive

Experimental Data Visualization

camptothecin

Statistics Data

camptothecin

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	8.000000000000000		1	1

Statistics Data Visualization

camptothecin

Compound Name:

camptothecin

Compound CID:

24360

Synonyms:

camptothecin Camptothecine 7689-03-4 (S)-(+)-Camptothecin Campathecin More...

Iupac Name:

(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

InChI:

InChI=1S/C20H16N2O4/c1-2-20(25)14-8-16-17-12(7-11-5-3-4-6-15(11)21-17)9-22(16)18(23)13(14)10-26-19(20)24/h3-8,25H,2,9-10H2,1H3/t20-/m0/s1

InChIKey:

VSJKWCGYPAHWDS-FQEVSTJZSA-N

Canonical Smiles:

CCC1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

Isomeric Smiles:

CC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=CC5=CC=CC=C5N=C4C3=C2)O

Molecular Weight:

348.4

Molecular Formula:

C20H16N2O4

Molecular Weight:

348.4

Molecular Formula:

C20H16N2O4

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

5

Rotatable Bond Count:

1

Heavy Atom Count:

26

Complexity:

742

camptothecin

Camptothecine

7689-03-4

(S)-(+)-Camptothecin

Campathecin

(+)-Camptothecine

d-Camptothecin

(+)-Camptothecin

20(S)-Camptothecine

21,22-Secocamptothecin-21-oic acid lactone

NSC94600

Camptothecine (8CI)

Camptothecine (S,+)

CHEMBL65

(4S)-4-ethyl-4-hydroxy-1H-pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione

UNII-XT3Z54Z28A

(S)-4-ethyl-4-hydroxy-1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione

MLS000766223

XT3Z54Z28A

CHEBI:27656

MFCD00081076

NSC-94600

(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo11.8.0.02,11.04,9.015,20henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione

251316-95-7

(S)-Camptothecin

(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo11.8.0.0^{2,11}.0^{4,9}.0^{15,20}henicosa-1(21),2,4(9),5,7,10,15(20)-heptaene-14,18-dione

1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-

20(S)-Camptothecin

4-ETHYL-4-HYDROXY-1,12-DIHYDRO-4H-2-OXA-6,12A-DIAZA-DIBENZOB,HFLUORENE-3,13-DIONE

SR-01000075798

SR-01000597379

d-camptothecine

(s)-camptothecine

Camptothecin, Camptotheca acuminata

Camptothecin,(S)

( )-Camptothecin

(S)-4-ethyl-4-hydroxy-1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione"

(S)-4-Ethyl-4-hydroxy-1H-pyrano3,4:6,7indolizino1,2-bquinoline-3,14-(4H,12H)-dione"

1H-Pyrano(3,4:6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-"

1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (4S)-"

1H-Pyrano3,4:6,7indolizino1,2-bquinoline-3,14(4H,12H)-dione, 4-ethyl-4-hydroxy-, (S)-

Prestwick_102

(+)-Camptothecin;

Spectrum_000299

Tocris-1100

SpecPlus_000712

camptothecin

Camptothecine

7689-03-4

(S)-(+)-Camptothecin

Campathecin

More...