Compound Summary
Tyrphostin B44, (-) enantiomer
Compound Information
Tyrphostin B44, (-) enantiomer
Compound Name: | Tyrphostin B44, (-) enantiomer |
Compound CID: | 5328772 |
Synonyms: | Tyrphostin B44, (-) enantiomer 133550-32-0 Tyrphostin B44 Tyrphostin AG 527 AG 527 More... |
Iupac Name: | (E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-[(1R)-1-phenylethyl]prop-2-enamide |
InChI: | InChI=1S/C18H16N2O3/c1-12(14-5-3-2-4-6-14)20-18(23)15(11-19)9-13-7-8-16(21)17(22)10-13/h2-10,12,21-22H,1H3,(H,20,23)/b15-9+/t12-/m1/s1 |
InChIKey: | UMGQVUWXNOJOSJ-KMHUVPDISA-N |
Canonical Smiles: | CC(C1=CC=CC=C1)NC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N |
Isomeric Smiles: | C[C@H](C1=CC=CC=C1)NC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N |
Molecular Weight: | 308.3 |
Molecular Formula: | C18H16N2O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Tyrphostin B44, (-) enantiomer
Molecular Weight: | 308.3 |
Molecular Formula: | C18H16N2O3 |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 23 |
Complexity: | 488 |
Synonyms
Tyrphostin B44, (-) enantiomer
| Tyrphostin B44, (-) enantiomer | Tyrphostin B44, (-) enantiomer |
|---|---|
Tyrphostin B44, (-) enantiomer |
133550-32-0 |
Tyrphostin B44 |
Tyrphostin AG 527 |
AG 527 |
(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1R)-1-phenylethylprop-2-enamide |
Tyrphostin B44(-) |
SR-01000076158 |
Tyrphostin B-44 |
Tocris-0578 |
Tyrphostin deriv. 44 |
ag527 |
Lopac0_001177 |
MLS002153178 |
BDBM4302 |
CHEMBL258767 |
cid_5328772 |
DTXSID90416171 |
HMS2235B13 |
alpha-Cyano-(-)-(R)-N-(alpha-phenethyl)-3,4-dihydroxycinnamide |
ZINC3871437 |
(-)-(R)-N-(alpha-Methylbenzyl)-3,4-dihydroxybenzylidinecyanoacetamide |
AG-527 |
HSCI1_000018 |
AKOS024458568 |
CCG-205251 |
NCGC00024662-01 |
NCGC00024662-02 |
NCGC00024662-03 |
NCGC00024662-04 |
NCGC00024662-05 |
SMR001230670 |
B6359 |
EU-0101177 |
M01337 |
T 4443 |
A806631 |
SR-01000597717 |
J-006401 |
J-006404 |
SR-01000076158-1 |
SR-01000076158-2 |
SR-01000597717-1 |
BRD-K43405658-001-01-8 |
(R,E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)acrylamide |
2-Cyano-3-(3,4-dihydroxyphenyl)-N-(R)-1-phenylethylacrylamide |
(-)-(R)-N-(alpha-Methylbenzyl)-3,4-dihydroxy-benzylidenecyanoacetamide |
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1R)-1-phenylethylprop-2-enamide |
(E)-2-cyano-3-(3,4-dihydroxyphenyl)-N-(1R)-1-phenylethyl-2-propenamide |
(E)-3-3,4-bis(oxidanyl)phenyl-2-cyano-N-(1R)-1-phenylethylprop-2-enamide |
(R)-(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylet hyl)-2-propenamide" |
(R)-(E)-2-Cyano-3-(3,4-dihydroxyphenyl)-N-(1-phenylethyl)-2-propenamide" |
Experimental Data
Tyrphostin B44, (-) enantiomer
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 11.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
Tyrphostin B44, (-) enantiomer
Statistics Data
Tyrphostin B44, (-) enantiomer
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 11.000000000000000 | 1 | 1 |
Statistics Data Visualization
Tyrphostin B44, (-) enantiomer
