Compound Summary
Tyrphostin AG-528
Compound Information
Tyrphostin AG-528
Compound Name: | Tyrphostin AG-528 |
Compound CID: | 1838043 |
Synonyms: | Tyrphostin AG-528 Tyrphostin AG 528 133550-49-9 Tyrphostin AG528 Tyrphostin B66 More... |
Iupac Name: | (E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile |
InChI: | InChI=1S/C18H14N2O3/c19-11-14(9-12-5-6-16(21)17(22)10-12)18(23)20-8-7-13-3-1-2-4-15(13)20/h1-6,9-10,21-22H,7-8H2/b14-9+ |
InChIKey: | MYKCTDWWIWGLHW-NTEUORMPSA-N |
Canonical Smiles: | C1CN(C2=CC=CC=C21)C(=O)C(=CC3=CC(=C(C=C3)O)O)C#N |
Isomeric Smiles: | C1CN(C2=CC=CC=C21)C(=O)/C(=C/C3=CC(=C(C=C3)O)O)/C#N |
Molecular Weight: | 306.3 |
Molecular Formula: | C18H14N2O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Tyrphostin AG-528
Molecular Weight: | 306.3 |
Molecular Formula: | C18H14N2O3 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 2 |
Heavy Atom Count: | 23 |
Complexity: | 536 |
Synonyms
Tyrphostin AG-528
| Tyrphostin AG-528 | Tyrphostin AG-528 |
|---|---|
Tyrphostin AG-528 |
Tyrphostin AG 528 |
133550-49-9 |
Tyrphostin AG528 |
Tyrphostin B66 |
(E)-3-(3,4-Dihydroxyphenyl)-2-(indoline-1-carbonyl)acrylonitrile |
AG 528 |
MFCD01076474 |
N-(3,4-Dihydroxybenzylidenecyanoacetyl)indoline |
Tyrphostin deriv. 66 |
Tyrphostin B66;AG-528 |
MLS002153157 |
CHEMBL56542 |
BDBM4314 |
Tyrphostin AG 528, ~90% |
cid_1838043 |
HMS2234E10 |
BCP24141 |
EX-A2364 |
ZINC2204479 |
AG-528 |
s6805 |
(E)-2-(2,3-dihydroindole-1-carbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile |
SMR001230652 |
HY-100499 |
CS-0019575 |
T3504 |
A17072 |
Tyrphostin AG 528; Tyrphostin B66; AG528 |
N-(3a?4a?Dihydroxybenzylidenecyanoacetyl)indoline |
(2E)-2-(2,3-dihydro-1H-indol-1-ylcarbonyl)-3-(3,4-dihydroxyphenyl)prop-2-enenitrile |
3-(3,4-Dihydroxyphenyl)-2-(2,3-dihydro-1H-indol)-1-ylcarbonylacrylonitrile |
Experimental Data
Tyrphostin AG-528
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 5.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
Tyrphostin AG-528
Statistics Data
Tyrphostin AG-528
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 5.000000000000000 | 1 | 1 |
Statistics Data Visualization
Tyrphostin AG-528
