Compound Summary
Tyrphostin AG 537
Compound Information
Tyrphostin AG 537
Compound Name: | Tyrphostin AG 537 |
Compound CID: | 5329255 |
Synonyms: | Tyrphostin AG 537 NSC676486 CHEMBL67535 (E)-2-cyano-N-3-(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoylaminopropyl-3-(3,4-dihydroxyphenyl)prop-2-enamide 140674-77-7 More... |
Iupac Name: | (E)-2-cyano-N-[3-[[(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoyl]amino]propyl]-3-(3,4-dihydroxyphenyl)prop-2-enamide |
InChI: | InChI=1S/C23H20N4O6/c24-12-16(8-14-2-4-18(28)20(30)10-14)22(32)26-6-1-7-27-23(33)17(13-25)9-15-3-5-19(29)21(31)11-15/h2-5,8-11,28-31H,1,6-7H2,(H,26,32)(H,27,33)/b16-8+,17-9+ |
InChIKey: | ZHOKHSGWBNPFQU-GONBZBRSSA-N |
Canonical Smiles: | C1=CC(=C(C=C1C=C(C#N)C(=O)NCCCNC(=O)C(=CC2=CC(=C(C=C2)O)O)C#N)O)O |
Isomeric Smiles: | C1=CC(=C(C=C1/C=C(/C(=O)NCCCNC(=O)/C(=C/C2=CC(=C(C=C2)O)O)/C#N)\C#N)O)O |
Molecular Weight: | 448.4 |
Molecular Formula: | C23H20N4O6 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Tyrphostin AG 537
Molecular Weight: | 448.4 |
Molecular Formula: | C23H20N4O6 |
Hydrogen Bond Donor Count: | 6 |
Hydrogen Bond Acceptor Count: | 8 |
Rotatable Bond Count: | 8 |
Heavy Atom Count: | 33 |
Complexity: | 797 |
Synonyms
Tyrphostin AG 537
| Tyrphostin AG 537 | Tyrphostin AG 537 |
|---|---|
Tyrphostin AG 537 |
NSC676486 |
CHEMBL67535 |
(E)-2-cyano-N-3-(E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoylaminopropyl-3-(3,4-dihydroxyphenyl)prop-2-enamide |
140674-77-7 |
bis-tyrphostin |
Dimeric Tyrphostin 2 |
Tyrphostin AG-537 |
Lopac-T-4693 |
Lopac0_001148 |
SCHEMBL846753 |
BDBM5149 |
DTXSID201017648 |
HMS3263F17 |
Tox21_501148 |
AG-537 |
HSCI1_000137 |
CCG-205222 |
LP01148 |
NSC-676486 |
SDCCGSBI-0051115.P002 |
NCGC00016027-01 |
NCGC00016027-02 |
NCGC00016027-03 |
NCGC00016027-04 |
NCGC00094411-01 |
NCGC00094411-02 |
NCGC00261833-01 |
EU-0101148 |
T 4693 |
SR-01000076160 |
SR-01000076160-1 |
BRD-K32906660-001-01-4 |
(2E,2E)-N,N-(propane-1,3-diyl)bis(2-cyano-3-(3,4-dihydroxyphenyl)acrylamide)" |
N,N-(Propane-1,3-diyl)bis(E)-2-cyano-3-(3,4-dihydroxyphenyl)acrylamide |
(2E)-2-cyano-N-{3-(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamidopropyl}-3-(3,4-dihydroxyphenyl)prop-2-enamide |
2-Cyano-N-{3-2-cyano-3-(3,4-dihydroxyphenyl)allanoylaminopropyl}-3-(3,4-dihydroxyphenyl)acrylamide |
Experimental Data
Tyrphostin AG 537
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | -8.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
Tyrphostin AG 537
Statistics Data
Tyrphostin AG 537
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -8.000000000000000 | 1 | 1 |
Statistics Data Visualization
Tyrphostin AG 537
