Compound Summary
Torin 1
Compound Information
Torin 1
Compound Name: | Torin 1 |
Compound CID: | 49836027 |
Synonyms: | Torin 1 1222998-36-8 Torin-1 Torin1 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzoh1,6naphthyridin-2(1H)-one More... |
Iupac Name: | 1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-one |
InChI: | InChI=1S/C35H28F3N5O2/c1-2-32(44)42-15-13-41(14-16-42)31-11-9-26(19-28(31)35(36,37)38)43-33(45)12-8-24-20-40-30-10-7-22(18-27(30)34(24)43)25-17-23-5-3-4-6-29(23)39-21-25/h3-12,17-21H,2,13-16H2,1H3 |
InChIKey: | AKCRNFFTGXBONI-UHFFFAOYSA-N |
Canonical Smiles: | CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F |
Isomeric Smiles: | CCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F |
Molecular Weight: | 607.6 |
Molecular Formula: | C35H28F3N5O2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Torin 1
Molecular Weight: | 607.6 |
Molecular Formula: | C35H28F3N5O2 |
Hydrogen Bond Donor Count: | 0 |
Hydrogen Bond Acceptor Count: | 8 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 45 |
Complexity: | 1110 |
Synonyms
Torin 1
| Torin 1 | Torin 1 |
|---|---|
Torin 1 |
1222998-36-8 |
Torin-1 |
Torin1 |
1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzoh1,6naphthyridin-2(1H)-one |
1-4-4-(1-Oxopropyl)-1-piperazinyl-3-(trifluoromethyl)phenyl-9-(3-quinolinyl)benzoh-1,6-naphthyridin-2(1H)-one |
CHEMBL1256459 |
CHEBI:84327 |
1-4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl-9-quinolin-3-ylbenzoh1,6naphthyridin-2-one |
1-4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl-9-(quinolin-3-yl)benzoh1,6naphthyridin-2(1H)-one |
1-4-4-(1-Oxopropyl)-1-piperazinyl-3-(trifluoromethyl)phenyl-9-(3-quinolinyl)-benzoH-1,6-naphthyridin-2(1H)-one |
cc-274 |
MLS003230943 |
GTPL8004 |
SCHEMBL7919574 |
DTXSID40678621 |
EX-A397 |
C35H28F3N5O2 |
HMS3265O03 |
HMS3265O04 |
HMS3265P03 |
HMS3265P04 |
AOB87112 |
BCP02504 |
BDBM50328584 |
MFCD18782653 |
s2827 |
ZINC64539506 |
AKOS024458054 |
CCG-270213 |
CS-0237 |
SB19258 |
NCGC00263215-01 |
NCGC00263215-02 |
NCGC00263215-06 |
NCGC00263215-11 |
AC-31516 |
AS-55924 |
HY-13003 |
QC-11638 |
SMR001913508 |
AB0035865 |
DB-062025 |
FT-0675299 |
Y0294 |
N11383 |
A850038 |
J-504118 |
Q27089007 |
1-4-(4-Propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl-9-(quinolin-3-yl)benzoh1,6naphthyridin-2(1H)-one |
Experimental Data
Torin 1
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 0.500000000000000 | umol/L | 22.000000000000000 | 28.000000000000000 | 0.270000000000000 | S | Dahomey | FEMALES | 29329306 | Active | |||
| Drosophila melanogaster | 1.000000000000000 | umol/L | 22.000000000000000 | 30.000000000000000 | 0.360000000000000 | S | Dahomey | FEMALES | 29329306 | Active | |||
| Drosophila melanogaster | 5.000000000000000 | umol/L | 22.000000000000000 | 33.000000000000000 | 0.500000000000000 | S | Dahomey | FEMALES | 29329306 | Active | |||
| Drosophila melanogaster | 10.000000000000000 | umol/L | 22.000000000000000 | 35.000000000000000 | 0.590000000000000 | S | Dahomey | FEMALES | 29329306 | Active |
Experimental Data Visualization
Torin 1
Statistics Data
Torin 1
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 0.590000000000000 | 1 | 4 |
Statistics Data Visualization
Torin 1
