Compound Summary
Nafadotride
Compound Information
Nafadotride
Compound Name: | Nafadotride |
Compound CID: | 3408722 |
Synonyms: | Nafadotride 149649-22-9 N-(1-butylpyrrolidin-2-yl)methyl-4-cyano-1-methoxynaphthalene-2-carboxamide N-(1-BUTYL-2-PYRROLIDINYL)METHYL-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE (+-)-nafadotride More... |
Iupac Name: | N-[(1-butylpyrrolidin-2-yl)methyl]-4-cyano-1-methoxynaphthalene-2-carboxamide |
InChI: | InChI=1S/C22H27N3O2/c1-3-4-11-25-12-7-8-17(25)15-24-22(26)20-13-16(14-23)18-9-5-6-10-19(18)21(20)27-2/h5-6,9-10,13,17H,3-4,7-8,11-12,15H2,1-2H3,(H,24,26) |
InChIKey: | IDZASIQMRGPBCQ-UHFFFAOYSA-N |
Canonical Smiles: | CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC |
Isomeric Smiles: | CCCCN1CCCC1CNC(=O)C2=C(C3=CC=CC=C3C(=C2)C#N)OC |
Molecular Weight: | 365.5 |
Molecular Formula: | C22H27N3O2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Nafadotride
Molecular Weight: | 365.5 |
Molecular Formula: | C22H27N3O2 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 7 |
Heavy Atom Count: | 27 |
Complexity: | 543 |
Synonyms
Nafadotride
| Nafadotride | Nafadotride |
|---|---|
Nafadotride |
149649-22-9 |
N-(1-butylpyrrolidin-2-yl)methyl-4-cyano-1-methoxynaphthalene-2-carboxamide |
N-(1-BUTYL-2-PYRROLIDINYL)METHYL-4-CYANO-1-METHOXY-2-NAPHTHALENECARBOXAMIDE |
(+-)-nafadotride |
CHEMBL286252 |
CHEBI:64191 |
2-Naphthalenecarboxamide, N-(1-butyl-2-pyrrolidinyl)methyl-4-cyano-1-methoxy- |
SMR000466292 |
GTPL44 |
MLS000758952 |
MLS001424218 |
SCHEMBL635866 |
DTXSID1042603 |
HMS2052A15 |
HMS2232B11 |
HMS3267P15 |
HMS3370D02 |
HMS3394A15 |
HMS3414K11 |
HMS3678K11 |
BCP27779 |
BDBM50133923 |
AKOS024257976 |
CCG-101119 |
NC00369 |
DB-043003 |
FT-0643448 |
L000428 |
SR-01000597572 |
A1-01951 |
J-008605 |
Q6958145 |
SR-01000597572-1 |
BRD-A71262238-001-04-3 |
N-((1-butylpyrrolidin-2-yl)methyl)-4-cyano-1-methoxy-2-naphthamide |
4-Cyano-1-methoxy-naphthalene-2-carboxylic acid (1-butyl-pyrrolidin-2-ylmethyl)-amide |
N-(1-Butyl-2-pyrrolidinyl)methyl-4-cyano-1-Methoxy-2naphthalenecarboxamide |
Experimental Data
Nafadotride
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 20.000000000000000 | umol/L | 44.630000000000000 | 48.190000000000000 | 7.972000000000000 | S | FEMALES | 33008901 | Active | ||||
| Drosophila melanogaster | 200.000000000000000 | umol/L | 43.170000000000000 | 45.560000000000000 | 5.545000000000000 | S | MALES | 33008901 | Active | ||||
| Caenorhabditis elegans | 10.000000000000000 | umol/L | 16.600000000000000 | 16.990000000000000 | 2.356000000000000 | NS | N2 | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 100.000000000000000 | umol/L | 17.250000000000000 | 16.180000000000000 | -6.231000000000000 | NS | N2 | 33008901 | Inactive |
Experimental Data Visualization
Nafadotride
Statistics Data
Nafadotride
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 2.356000000000000 | 1 | 2 | |
| Drosophila melanogaster | 7.972000000000000 | 1 | 2 |
Statistics Data Visualization
Nafadotride
