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Compound Summary

Mevastatin

Compound Information

Mevastatin

Compound Name:	Mevastatin
Compound CID:	64715
Synonyms:	Mevastatin compactin 73573-88-3 ML-236B Mevastatina More...
Iupac Name:	[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate
InChI:	InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1
InChIKey:	AJLFOPYRIVGYMJ-INTXDZFKSA-N
Canonical Smiles:	CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O
Isomeric Smiles:	CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O
Molecular Weight:	390.5
Molecular Formula:	C23H34O5

Compound Structure

2D Structure:

3D Structure:

Computed Properties

Mevastatin

Molecular Weight:	390.5
Molecular Formula:	C23H34O5
Hydrogen Bond Donor Count:	1
Hydrogen Bond Acceptor Count:	5
Rotatable Bond Count:	7
Heavy Atom Count:	28
Complexity:	637

Synonyms

Mevastatin

Mevastatin	Mevastatin
Mevastatin	compactin
73573-88-3	ML-236B
Mevastatina	Mevastatine
Mevastatinum	Mevastatinum INN-Latin
Antibiotic ML 236B	CS 500
UNII-1UQM1K0W9X	ML 236 B
1UQM1K0W9X	CHEMBL54440
(1S,7S,8S,8aR)-8-2-(2R,4R)-4-hydroxy-6-oxooxan-2-ylethyl-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate	CHEBI:34848
MFCD05662341	ML236B
Mevastatin INN	Compactin (penicillium)
Mevastatine INN-French	Mevastatina INN-Spanish
(S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate	Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester, (2S)-
SMR000336944	CCRIS 4505
kompaktin	NCGC00095942-01
Mevastatin- Bio-X	EC 700-442-0
SCHEMBL1116	DSSTox_CID_20684
DSSTox_RID_79540	DSSTox_GSID_40684
Lopac0_000754	MLS000721804
MLS000759452	MLS001424284
MLS002207227	GTPL3031
DTXSID4040684	Mevastatin, >=96% (HPLC)
HMS2052P07	HMS2089D10
HMS2232N09	HMS3262G10
HMS3268A19	HMS3412H15
HMS3676H15	HMS3713B06
ZINC3833876	Tox21_111540
Tox21_500754	BDBM50011036
CS-500	NSC779705
s4223	AKOS015994712
Mevastatin, >=95% (HPLC), powder	CCG-101174
CS-1234	DB06693
KS-1085	LP00754
NC00424	NSC 759322
NSC-779705	SDCCGSBI-0050732.P002
7-(1,2,6,7,8,8a-Hexahydro-2-methyl-8-(2-methylbutyryloxy)naphthyl)-3-hydroxyheptan-5-olide	SMP1_000077
NCGC00025202-04	NCGC00261439-01
(1S,7S,8S,8aR)-8-(2-((2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl(2S)-2-methylbutanoate	BM164666
Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (2S)-	Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha(R),7-beta,8-beta(2S,4S*),8a-beta))-
HY-17408	I518
Mevastatin 100 microg/mL in Acetonitrile	AB0013739
CAS-73573-88-3	B1788
EU-0100754	M2275
H11997	M 2537
AB00588266-06	AB00588266-08
AB00588266_09	573M883
A837861	Q414407
SR-01000729493	L-637312
SR-01000729493-4	BRD-K94441233-001-03-1
BRD-K94441233-001-17-1	(1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate
(1S,7S,8S,8aR)-8-{2-(2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-ylethyl}-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate	(S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate
(S)-2-Methyl-butyric acid (1S,7S,8S,8aR)-8-2-((2R,4R)-4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester	2-Methyl-butyric acid 8-2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester
2-Methyl-butyric acid 8-2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester((+)-compactin)	2-Methyl-butyric acid 8-2-(4-hydroxy-6-oxo-tetrahydro-pyran-2-yl)-ethyl-7-methyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester(compactin)

Experimental Data

Mevastatin

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Caenorhabditis elegans	33.000000000000000	umol/L			-2.000000000000000				NS	N2		24134630	Inactive

Experimental Data Visualization

Mevastatin

Statistics Data

Mevastatin

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Caenorhabditis elegans	-2.000000000000000		1	1

Statistics Data Visualization

Mevastatin

Compound Name:

Mevastatin

Compound CID:

64715

Synonyms:

Mevastatin compactin 73573-88-3 ML-236B Mevastatina More...

Iupac Name:

[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate

InChI:

InChI=1S/C23H34O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h6,8-9,14-15,17-20,22,24H,4-5,7,10-13H2,1-3H3/t14-,15-,17+,18+,19-,20-,22-/m0/s1

InChIKey:

AJLFOPYRIVGYMJ-INTXDZFKSA-N

Canonical Smiles:

CCC(C)C(=O)OC1CCC=C2C1C(C(C=C2)C)CCC3CC(CC(=O)O3)O

Isomeric Smiles:

CC[C@H](C)C(=O)O[C@H]1CCC=C2[C@H]1[C@H]([C@H](C=C2)C)CC[C@@H]3C[C@H](CC(=O)O3)O

Molecular Weight:

390.5

Molecular Formula:

C23H34O5

Molecular Weight:

390.5

Molecular Formula:

C23H34O5

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

5

Rotatable Bond Count:

7

Heavy Atom Count:

28

Complexity:

637

Mevastatin

compactin

73573-88-3

ML-236B

Mevastatina

Mevastatine

Mevastatinum

Mevastatinum INN-Latin

Antibiotic ML 236B

CS 500

UNII-1UQM1K0W9X

ML 236 B

1UQM1K0W9X

CHEMBL54440

(1S,7S,8S,8aR)-8-2-(2R,4R)-4-hydroxy-6-oxooxan-2-ylethyl-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2S)-2-methylbutanoate

CHEBI:34848

MFCD05662341

ML236B

Mevastatin INN

Compactin (penicillium)

Mevastatine INN-French

Mevastatina INN-Spanish

(S)-((1S,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl) 2-methylbutanoate

Butanoic acid, 2-methyl-, (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-2-(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-ylethyl-1-naphthalenyl ester, (2S)-

SMR000336944

CCRIS 4505

kompaktin

NCGC00095942-01

Mevastatin- Bio-X

EC 700-442-0

SCHEMBL1116

DSSTox_CID_20684

DSSTox_RID_79540

DSSTox_GSID_40684

Lopac0_000754

MLS000721804

MLS000759452

MLS001424284

MLS002207227

GTPL3031

DTXSID4040684

Mevastatin, >=96% (HPLC)

HMS2052P07

HMS2089D10

HMS2232N09

HMS3262G10

Mevastatin

compactin

73573-88-3

ML-236B

Mevastatina

More...

Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-7-methyl-8-(2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl)-1-naphthalenyl ester, (1S-(1-alpha(R),7-beta,8-beta(2S,4S*),8a-beta))-