Compound Summary
LY-367,265
Compound Information
LY-367,265
Compound Name: | LY-367,265 |
Compound CID: | 4605800 |
Synonyms: | LY-367,265 LY-367265 UNII-SS58UXZ8ZU SS58UXZ8ZU LY367265 More... |
Iupac Name: | 3-[2-[4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl]ethyl]-2lambda6-thia-1,3-diazatricyclo[6.3.1.04,12]dodeca-4,6,8(12)-triene 2,2-dioxide |
InChI: | InChI=1S/C24H25FN4O2S/c25-19-6-7-20-21(16-26-22(20)15-19)17-8-11-27(12-9-17)13-14-28-23-5-1-3-18-4-2-10-29(24(18)23)32(28,30)31/h1,3,5-8,15-16,26H,2,4,9-14H2 |
InChIKey: | BJIPVHLRWSDKOS-UHFFFAOYSA-N |
Canonical Smiles: | C1CC2=C3C(=CC=C2)N(S(=O)(=O)N3C1)CCN4CCC(=CC4)C5=CNC6=C5C=CC(=C6)F |
Isomeric Smiles: | C1CC2=C3C(=CC=C2)N(S(=O)(=O)N3C1)CCN4CCC(=CC4)C5=CNC6=C5C=CC(=C6)F |
Molecular Weight: | 452.5 |
Molecular Formula: | C24H25FN4O2S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
LY-367,265
Molecular Weight: | 452.5 |
Molecular Formula: | C24H25FN4O2S |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 32 |
Complexity: | 845 |
Synonyms
LY-367,265
| LY-367,265 | LY-367,265 |
|---|---|
LY-367,265 |
LY-367265 |
UNII-SS58UXZ8ZU |
SS58UXZ8ZU |
LY367265 |
LY 367265 |
CHEMBL1079460 |
210751-39-6 |
NCGC00015600-01 |
Lopac-L-2411 |
Lopac0_000648 |
MLS002172448 |
SCHEMBL7793847 |
CHEBI:183634 |
DTXSID801017165 |
HMS2232M07 |
HMS3262A17 |
HMS3373J15 |
Tox21_500648 |
BDBM50313283 |
ZINC52569996 |
CCG-204735 |
LP00648 |
SDCCGSBI-0050628.P002 |
NCGC00015600-02 |
NCGC00015600-03 |
NCGC00015600-04 |
NCGC00094014-01 |
NCGC00094014-02 |
NCGC00261333-01 |
1-(2-(4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl)ethyl)-5,6-dihydro1H,4H-(1,2,5)thiadiazolo(4.3.2-ij)quinoline-2,2-dioxide |
1-2-4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinylethyl-5,6-dihydro-1H,4H-1,2,5thiadiazolo4.3.2-ijquinoline-2,2-dioxide |
SMR001254083 |
EU-0100648 |
L 2411 |
L020228 |
SR-01000075958 |
SR-01000075958-1 |
Q15409397 |
1-{2-4-(6-Fluoro-1H-indol-3-yl)-3,6-dihydro-2H-pyridin-1-yl-ethyl}-4,5-dihydro-1H,3H-2-thia-1,2a-diaza-acenaphthylene 2,2-dioxide |
1-{2-4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-ylethyl}-5,6-dihydro-1H,4H-1,2,5thiadiazolo4,3,2-ijquinoline 2,2-dioxide |
1-{2-4-(6-fluoro-1H-indol-3-yl)-3,6-dihydropyridin-1(2H)-ylethyl}-5,6-dihydro-4H-2lambda(6)-1,2,5thiadiazolo4,3,2-ijquinoline-2,2(1H)-dione |
1H,4H-(1,2,5)Thiadiazolo(4,3,2-ij)quinoline, 1-(2-(4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl)ethyl)-5,6-dihydro-, 2,2-dioxide |
1H,4H-(1,2,5)Thiadiazolo(4,3,2-ij)quinoline, 1-(2-(4-(6-fluoro-1H-indol-3-yl)-3,6-dihydro-1(2H)-pyridinyl)ethyl)-5,6-dihydro-, 2,2-dioxide |
Experimental Data
LY-367,265
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 34.000000000000000 | S | N2 | 24134630 | Active | ||||||
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 40.000000000000000 | NS | N2 | 24134630 | Inactive | ||||||
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 34.000000000000000 | S | N2 | 33683565 | Active |
Experimental Data Visualization
LY-367,265
Statistics Data
LY-367,265
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 40.000000000000000 | 2 | 3 |
Statistics Data Visualization
LY-367,265
