Compound Summary
GW2974
Compound Information
GW2974
Compound Name: | GW2974 |
Compound CID: | 6603857 |
Synonyms: | GW2974 202272-68-2 EGFR/HER2 Inhibitor CHEMBL30432 GW282974X More... |
Iupac Name: | 4-N-(1-benzylindazol-5-yl)-6-N,6-N-dimethylpyrido[3,4-d]pyrimidine-4,6-diamine |
InChI: | InChI=1S/C23H21N7/c1-29(2)22-11-19-20(13-24-22)25-15-26-23(19)28-18-8-9-21-17(10-18)12-27-30(21)14-16-6-4-3-5-7-16/h3-13,15H,14H2,1-2H3,(H,25,26,28) |
InChIKey: | DYYZXRCFCVDSKD-UHFFFAOYSA-N |
Canonical Smiles: | CN(C)C1=NC=C2C(=C1)C(=NC=N2)NC3=CC4=C(C=C3)N(N=C4)CC5=CC=CC=C5 |
Isomeric Smiles: | CN(C)C1=NC=C2C(=C1)C(=NC=N2)NC3=CC4=C(C=C3)N(N=C4)CC5=CC=CC=C5 |
Molecular Weight: | 395.5 |
Molecular Formula: | C23H21N7 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
GW2974
Molecular Weight: | 395.5 |
Molecular Formula: | C23H21N7 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 5 |
Heavy Atom Count: | 30 |
Complexity: | 552 |
Synonyms
GW2974
| GW2974 | GW2974 |
|---|---|
GW2974 |
202272-68-2 |
EGFR/HER2 Inhibitor |
CHEMBL30432 |
GW282974X |
4-N-(1-benzylindazol-5-yl)-6-N,6-N-dimethylpyrido3,4-dpyrimidine-4,6-diamine |
N6,N6-dimethyl-N4-1-(phenylmethyl)-5-indazolylpyrido3,4-dpyrimidine-4,6-diamine |
N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido 3,4-dpyrimidine-4,6-diamine |
GW 2974 |
GW-2974 |
Lopac-G-0668 |
Lopac0_000509 |
SCHEMBL1737530 |
CHEBI:95273 |
DTXSID40424963 |
HMS3261F19 |
HMS3303J07 |
HMS3305C14 |
Tox21_500509 |
BDBM50099963 |
GW-974 |
MFCD04974495 |
NSC756204 |
ZINC18371391 |
CCG-204600 |
LP00509 |
NSC-756204 |
SDCCGSBI-0050493.P002 |
N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido-3,4-d-pyrimidine-4,6-diamine |
SMP2_000268 |
SMP2_000301 |
NCGC00015468-01 |
NCGC00015468-02 |
NCGC00015468-03 |
NCGC00015468-04 |
NCGC00015468-05 |
NCGC00015468-06 |
NCGC00015468-07 |
NCGC00093907-01 |
NCGC00093907-02 |
NCGC00261194-01 |
GW2974, >=98% (HPLC), solid |
EU-0100509 |
G 0668 |
AB01092265-01 |
SR-01000075892 |
J-013131 |
SR-01000075892-1 |
Q27167122 |
N*4*-(1-Benzyl-1H-indazol-5-yl)-N*6*,N*6*-dimethyl-pyrido3,4-dpyrimidine-4,6-diamine |
N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido3,4-dpyrimidine-4,6-diamine |
N4-(1-Benzyl-1H-indazol-5-yl)-N6,N6-dimethyl-pyrido3,4-dpyrimidine4-4,6-diamine |
Experimental Data
GW2974
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | 7.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
GW2974
Statistics Data
GW2974
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 7.000000000000000 | 1 | 1 |
Statistics Data Visualization
GW2974
