Compound Summary
Dofetilide
Compound Information
Dofetilide
Compound Name: | Dofetilide |
Compound CID: | 71329 |
Synonyms: | Dofetilide 115256-11-6 Tikosyn Dofetilida Dofetilidum More... |
Iupac Name: | N-[4-[2-[2-[4-(methanesulfonamido)phenoxy]ethyl-methylamino]ethyl]phenyl]methanesulfonamide |
InChI: | InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3 |
InChIKey: | IXTMWRCNAAVVAI-UHFFFAOYSA-N |
Canonical Smiles: | CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C |
Isomeric Smiles: | CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C |
Molecular Weight: | 441.6 |
Molecular Formula: | C19H27N3O5S2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Dofetilide
Molecular Weight: | 441.6 |
Molecular Formula: | C19H27N3O5S2 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 8 |
Rotatable Bond Count: | 11 |
Heavy Atom Count: | 29 |
Complexity: | 672 |
Synonyms
Dofetilide
| Dofetilide | Dofetilide |
|---|---|
Dofetilide |
115256-11-6 |
Tikosyn |
Dofetilida |
Dofetilidum |
Dofetilidum INN-Latin |
Dofetilida INN-Spanish |
UK 68798 |
UK-68798 |
UK-68,798 |
Dofetilide (Tikosyn) |
UNII-R4Z9X1N2ND |
N-(4-(2-(methyl(2-(4-(methylsulfonamido)phenoxy)ethyl)amino)ethyl)phenyl)methanesulfonamide |
C19H27N3O5S2 |
beta-((p-Methanesulfonamidophenethyl)methylamino)methanesulfono-p-phenetidide |
CHEMBL473 |
R4Z9X1N2ND |
1-(4-Methanesulphonamidophenoxy)-2-N-(4-methanesulphonamidophenethyl)-N-methylaminoethane |
Methanesulfonamide, N-4-2-methyl2-4-(methylsulfonyl)aminophenoxyethylaminoethylphenyl- |
CHEBI:4681 |
N-4-2-Methyl2-4-(methylsulfonyl)aminophenoxyethylaminoethylphenylmethanesulfonamide |
NCGC00164549-01 |
DSSTox_CID_26433 |
DSSTox_RID_81610 |
DSSTox_GSID_46433 |
Xelide |
Methanesulfonamide, N-(4-(2-(methyl(2-(4-((methylsulfonyl)amino)phenoxy)ethyl)amino)ethyl)phenyl)- |
N-(4-{2-methyl(2-{4-(methylsulfonyl)aminophenoxy}ethyl)aminoethyl}phenyl)methanesulfonamide |
SMR000466333 |
Tikosyn (TN) |
CAS-115256-11-6 |
UK 68,798 |
N-4-2-2-4-(methanesulfonamido)phenoxyethyl-methylaminoethylphenylmethanesulfonamide |
HSDB 7927 |
Dofetilide USAN:USP:INN:BAN |
Dofetilide- Bio-X |
UK68798 |
UK 68789 |
SCHEMBL16135 |
Dofetilide (JAN/USP/INN) |
MLS000759442 |
MLS001424185 |
MLS006010154 |
GTPL2604 |
Dofetilide, >=98% (HPLC) |
DTXSID5046433 |
HMS2051N14 |
HMS2089F03 |
HMS2232H19 |
HMS3261G03 |
HMS3370B18 |
HMS3393N14 |
HMS3655A17 |
HMS3715H20 |
ZINC596731 |
ACT04222 |
BCP04770 |
HY-B0232 |
Tox21_112178 |
Tox21_500351 |
AC-385 |
BDBM50031720 |
MFCD00869707 |
NSC786034 |
s1658 |
AKOS005259921 |
Tox21_112178_1 |
BCP9000619 |
CCG-101037 |
DB00204 |
NC00287 |
NSC-786034 |
MRF-0000317 |
N-4-2-2-4-(methanesulfonamido)phenoxyethyl-methyl-aminoethylphenylmethanesulfonamide |
NCGC00164549-02 |
NCGC00261036-01 |
BD164377 |
I881 |
BCP0726000009 |
AB0004775 |
DB-041252 |
FT-0631076 |
SW197667-2 |
C07751 |
D00647 |
H11953 |
AB00639976-06 |
AB00639976-08 |
AB00639976_09 |
256D116 |
A803396 |
SR-01000759368 |
J-003271 |
Q3712521 |
SR-01000759368-4 |
BRD-K86887724-001-05-6 |
Dofetilide, United States Pharmacopeia (USP) Reference Standard |
1-(4-Methansulphonamidophenoxy)-2-N-(4-methanesulphonamidophenethyl)-N-methylaminoethane |
N-4-2-2-(4-methanesulfonamidophenyl)ethyl-methylaminoethoxyphenylmethanesulfonamide |
(Dofetilide) N-4-(2-{2-(4-Methanesulfonylamino-phenyl)-ethyl-methylamino}-ethoxy)-phenyl-methanesulfonamide |
N-4-(2-{2-(4-methanesulfonamidophenoxy)ethyl(methyl)amino}ethyl)phenylmethanesulfonamide |
N-4-(2-{2-(4-methanesulfonylamino-phenoxy)-ethyl-methyl-amino}-ethyl)-phenyl-methanesulfonamide |
N-4-(2-{2-(4-Methanesulfonylamino-phenyl)-ethyl-methyl-amino}-ethoxy)-phenyl-methanesulfonamide (dofetilide) |
N-4-(2-{2-(4-Methanesulfonylamino-phenyl)-ethyl-methyl-amino}-ethoxy)-phenyl-methanesulfonamide (UK-68798) |
N-4-(2-{2-(4-METHANESULFONYLAMINO-PHENYL)-ETHYL-METHYL-AMINO}-ETHOXY)-PHENYL-METHANESULFONAMIDE DOFETILIDE |
N-4-(2-{2-4-(methanesulphonamido)phenoxyl-N-methylethylamino}ethyl)phenyl-methanesulphonamide |
Experimental Data
Dofetilide
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 20.000000000000000 | umol/L | 47.990000000000000 | 46.910000000000000 | -2.250000000000000 | NS | FEMALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 200.000000000000000 | umol/L | 42.220000000000000 | 43.900000000000000 | 3.980000000000000 | NS | MALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 100.000000000000000 | umol/L | 15.990000000000000 | 16.750000000000000 | 4.726000000000000 | S | N2 | 33008901 | Active | ||||
| Caenorhabditis elegans | 10.000000000000000 | umol/L | 16.180000000000000 | 16.060000000000000 | -0.724900000000000 | S | N2 | 33008901 | Inactive |
Experimental Data Visualization
Dofetilide
Statistics Data
Dofetilide
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 4.726000000000000 | 1 | 2 | |
| Drosophila melanogaster | 3.980000000000000 | 1 | 2 |
Statistics Data Visualization
Dofetilide
