Compound Summary

Diltiazem hydrochloride
  Compound Information
 Diltiazem hydrochloride

Compound Name:

Diltiazem hydrochloride

Compound CID:

62920

Synonyms:

Diltiazem hydrochloride

Diltiazem HCl

33286-22-5

(+)-cis-Diltiazem hydrochloride

Dilzem

More...

Iupac Name:

[(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride

InChI:

InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1

InChIKey:

HDRXZJPWHTXQRI-BHDTVMLSSA-N

Canonical Smiles:

CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

Isomeric Smiles:

CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl

Molecular Weight:

451

Molecular Formula:

C22H27ClN2O4S

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 Diltiazem hydrochloride

Molecular Weight:

451

Molecular Formula:

C22H27ClN2O4S

Hydrogen Bond Donor Count:

1

Hydrogen Bond Acceptor Count:

6

Rotatable Bond Count:

7

Heavy Atom Count:

30

Complexity:

565

  Synonyms
 Diltiazem hydrochloride

Diltiazem hydrochloride Diltiazem hydrochloride

Diltiazem hydrochloride

Diltiazem HCl

33286-22-5

(+)-cis-Diltiazem hydrochloride

Dilzem

Tiazac

CRD-401

Herbesser

Dilzene

Lacerol

Masdil

Tildiem

Mono-Tildiem

Bi-Tildiem

Cardizem CD

Cardizem LA

Dilthiazem hydrochloride

Cardil

Dilren

Adizem

Diltiazem (hydrochloride)

(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzob1,4thiazepin-3-yl acetate hydrochloride

UNII-OLH94387TE

RG 83606

Diltiazem HCl (Tiazac)

MFCD00069252

MLS000028432

OLH94387TE

103532-26-9

RG 83606 HCl

CHEBI:645509

Anoheal

(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride

(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl acetate;hydrochloride

Dilzicardin

Altiazem

Anginyl

Angitil

Angizem

Britiazim

Calcicard

Calnurs

Cardiazem

Cirilen

Citizen

Clarute

Corazet

Deltazen

Dilacor

Diladel

Dilatam

Dilatame

Dilcard

Dilgard

Dilicardin

Dilpral

Dilrene

Diltahexal

Diltelan

Diltiasyn

Diltikor

Diltime

Dinisor

Dodexen

Entrydil

Farmabes

Gadoserin

Helsibon

Incoril

Kaltiazen

Levozem

Longazem

Lytelsen

Metazem

Miocardie

Oxycardil

Pazeadin

Pentilzeno

Poltiazem

Presoken

SMR000058375

Surazem

Tilazem

Trumsal

Ziruvate

Bruzem

Carzem

Diatal

Dilfar

Dilsal

Diltam

Diltan

Doclis

Dyalac

Etizen

Etyzen

Herben

Kardil

Myonil

Slozen

Tiadil

Tiaves

Ubicor

Zildem

Carex

Coras

Dazil

Dilem

Dilso

Hesor

Tazem

Apo-diltiazem

Iski

Altiazem Retard

Cardizem Retard

Diltiazem Merck

Diltiazem Stada

Diltiazem Verla

Diltiazem-Mepha

33286-22-5 (HCl)

Cardil Retard

Dil-Sonaramia

Diltiazem-Isis

Dilzem Retard

Dinisor Retard

Myonil Retard

Novo-Diltazem

Syn-Diltiazem

Tildiem Retard

Diltiazem Basics

Diltiazem-Cophar

Uni Masdil

WL Diltiazem

Altiazem RR

Cardizem SR

Diltiazem AWD

Diltiazem GNR

Diltiazem MSD

Diltiazem-GRY

Cirilen AP

Diltiazem Henning

Diltiazem UPSA

Tildiem CR

Tildiem LA

Adizem-CD

Cartia XT

Diltan SR

Diltiazem Eu Rho

Dilzem RR

Taztia XT

Viazem SR

Viazem XL

Herbesser 60

C22H26N2O4S.HCl

(2S-cis)-3-Acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride

(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl acetate;hydron;chloride

38411-61-9

Herbesser 90 SR

Tilazem 90

Diltiazem chloridrate

Dilatam 120

Tilazem AS 60

Tilazem AS 90

Dilzereal 90 Retard

Herbesser 180 SR

Dolizem

Iski-90 SR

Diltia XT

Dilt-XR

Dodexen A.P.

Presokin A. P.

MK-793

CRD 401

Tiazac extended release

Diltiazem, Hydrochloride

SR-01000003042

RG-83606

EINECS 251-443-3

Dilacor XR Extended Release Capsules

Milptin

Carzen

Slozem

CRD401

Dilthiazem HCl

DOV diltiazem

Uni-Masdil

Cardizem XL

Tiazac XC

Cardizem (TN)

Prestwick_176

acetate hydrochloride

EINECS 253-918-0

Dilacor XR (TN)

Cartia XT (TN)

Opera_ID_79

Diltiazem hydrochloride USAN:USP:JAN

Dilt-CD (TN)

(+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester monohydrochloride

2-(2S,3S)-3-(acetyloxy)-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl-N,N-dimethylethanaminium chloride

CHEMBL1697

Diltiazem Hydrochloride,(S)

SCHEMBL15457

(+)-5-(2-(Dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester) monohydrochloride

MLS001148257

MLS002222179

DTXSID8040147

AMY8835

SLV-324

VEN-307

HMS1568K10

(2S-trans)-Diltiazem Hydrochloride

ACT02682

BCP13814

Tox21_500327

BNP-32762

Diltiazem hydrochloride (JP17/USP)

s1865

3,3,3-phosphinylidynetrispropionamide

AKOS015961992

CCG-220134

CCG-221631

KS-5089

LP00327

NC00558

NSC 759576

tetrahydrobenzob1,4thiazepin-3-yl

NCGC00093768-01

NCGC00261012-01

(2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride

1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-, monohydrochloride, cis-(+)-

1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (+)-cis-

AC-15189

AC-32469

AS-13703

BD166408

cis-(1)-3-Acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride

HY-14656

(+)-cis-Diltiazem Hydrochloride, >/=98%

(2S,3S)-5-(2-(dimethylamino)ethyl)-2

D3662

EU-0100327

ST50320016

SW196487-3

BIM-0050315.0001

D 2521

D00616

Diltiazem, Hydrochloride - CAS 33286-22-5

F20448

J10138

M01693

(+)-cis-Diltiazem hydrochloride, >=99% (HPLC)

286D225

SR-01000075327

J-019130

SR-01000003042-2

SR-01000003042-4

SR-01000075327-1

Q27105183

Diltiazem Hydrochloride 1.0 mg/ml in Acetonitrile (as free base)

Diltiazem hydrochloride, European Pharmacopoeia (EP) Reference Standard

Diltiazem hydrochloride, United States Pharmacopeia (USP) Reference Standard

Diltiazem for system suitability, European Pharmacopoeia (EP) Reference Standard

(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

(2S,3S)-5-(2-(DIMETHYLAMINO)ETHYL)-2-(4-METHOXYPHENYL)-4-OXO-2,3,4,5-TETRAHYDROBENZOB1,4THIAZEPIN-3-YL ACETATE HCL

(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2H,3H-benzob1,4 -thiazaperhydroepin-3-yl acetate, chloride

(2S-cis)-3-(Acetyloxy)-5-2-(dimethylamino)ethyl-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride

Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzob1,4thiazepin-3-yl ester; hydrochloride

cis-(+)-3-acetoxy-2,3-dihydro-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5H)-one hydrochloride

Diltiazem hydrochloride solution, 1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material

  Experimental Data
 Diltiazem hydrochloride

Species Dose Unit Control(Avg days) Treatment(Avg days) Avg/Med Lifespan Change(%) Control(Max days) Treatment(Max days) Max Lifespan Change(%) Significant Strain Gender PubMed Avg/Med Lifespan Change tab
Caenorhabditis elegans 33.000000000000000 umol/L -2.000000000000000 NS N2 24134630 Inactive
  Experimental Data Visualization
 Diltiazem hydrochloride

  Statistics Data
 Diltiazem hydrochloride

Species Avg/Med Lifespan Change(%) Max Lifespan Change(%) Count Reference Count Data point
Caenorhabditis elegans -2.000000000000000 1 1
  Statistics Data Visualization
 Diltiazem hydrochloride

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