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Compound Summary

Crizotinib

Compound Information

Crizotinib

Compound Name:	Crizotinib
Compound CID:	11626560
Synonyms:	Crizotinib 877399-52-5 Xalkori PF-02341066 (R)-crizotinib More...
Iupac Name:	3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine
InChI:	InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1
InChIKey:	KTEIFNKAUNYNJU-GFCCVEGCSA-N
Canonical Smiles:	CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Isomeric Smiles:	C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N
Molecular Weight:	450.3
Molecular Formula:	C21H22Cl2FN5O

Compound Structure

2D Structure:

3D Structure:

Computed Properties

Crizotinib

Molecular Weight:	450.3
Molecular Formula:	C21H22Cl2FN5O
Hydrogen Bond Donor Count:	2
Hydrogen Bond Acceptor Count:	6
Rotatable Bond Count:	5
Heavy Atom Count:	30
Complexity:	558

Synonyms

Crizotinib

Crizotinib	Crizotinib
Crizotinib	877399-52-5
Xalkori	PF-02341066
(R)-crizotinib	PF-2341066
PF 2341066	(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
3-(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy-5-1-(4-piperidinyl)-1H-pyrazol-4-yl-2-pyridinamine	PF 02341066
Crizotinib (PF-02341066)	UNII-53AH36668S
PF2341066	CHEMBL601719
Crizotinib (PF-2341066)	CHEBI:64310
877399-52-5 (free base)	53AH36668S
3-(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy-5-1-(piperidin-4-yl)-1H-pyrazol-4-ylpyridin-2-amine	3-(1r)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy-5-(1-Piperidin-4-Yl-1h-Pyrazol-4-Yl)pyridin-2-Amine
3-(1R)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY-5-1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YLPYRIDIN-2-AMINE	(R)-3-1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine
Xalkori (TN)	C21H22Cl2FN5O
Crizotinib USAN:INN	crizotinibum
VGH	Crizotinib- Bio-X
PF02341066	SCHEMBL93829
PF-2341066,Crizotinib	cc-190
Crizotinib (JAN/USAN/INN)	GTPL4903
QCR-32	Crizotinib, >=98% (HPLC)
PF-2341066 (Crizotinib)	PF-2341066 - Crizotinib
AOB2688	EX-A096
SYN1139	PF-02341066 (Crizotinib)
BCPP000116	DTXSID701009329
3-(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine	AMY10313
BDBM50306682	MFCD12407409
NSC749005	NSC749769
NSC800080	ZINC35902489
AKOS015901233	AKOS015995207
CCG-264803	DB08865
GS-6178	NSC 756645
NSC-749005	NSC-749769
NSC-800080	NCGC00250400-01
NCGC00250400-02	NCGC00250400-09
NCGC00250400-12	2-Pyridinamine, 3-((1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(4-piperidinyl)-1H-pyrazol-4-yl)-
BC164334	HY-50878
AB0027203	BB 0261738
SW202555-3	W9013
D09731	399P525
J-510370	Q5186964
BRD-K78431006-001-01-1	BRD-K78431006-001-03-7
877399-52-5, 877399-53-6 (acetate)	3-(2,6-dichloro-3-fluorobenzyloxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine
(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-am ine	3-(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy-5-1-(4-piperidinyl)-1H-pyrazol-4-yl-2-Pyridinamine
3-(R)-1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

Experimental Data

Crizotinib

Species	Dose	Unit	Control(Avg days)	Treatment(Avg days)	Avg/Med Lifespan Change(%)	Control(Max days)	Treatment(Max days)	Max Lifespan Change(%)	Significant	Strain	Gender	PubMed	Avg/Med Lifespan Change tab
Drosophila melanogaster	200.000000000000000	nM	37.560000000000000	33.240000000000000	-0.120000000000000				NS	w1118		31278140	Inactive

Experimental Data Visualization

Crizotinib

Statistics Data

Crizotinib

Species	Avg/Med Lifespan Change(%)	Max Lifespan Change(%)	Count Reference	Count Data point
Drosophila melanogaster	-0.120000000000000		1	1

Statistics Data Visualization

Crizotinib

Compound Name:

Crizotinib

Compound CID:

11626560

Synonyms:

Crizotinib 877399-52-5 Xalkori PF-02341066 (R)-crizotinib More...

Iupac Name:

3-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

InChI:

InChI=1S/C21H22Cl2FN5O/c1-12(19-16(22)2-3-17(24)20(19)23)30-18-8-13(9-27-21(18)25)14-10-28-29(11-14)15-4-6-26-7-5-15/h2-3,8-12,15,26H,4-7H2,1H3,(H2,25,27)/t12-/m1/s1

InChIKey:

KTEIFNKAUNYNJU-GFCCVEGCSA-N

Canonical Smiles:

CC(C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Isomeric Smiles:

C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=C(N=CC(=C2)C3=CN(N=C3)C4CCNCC4)N

Molecular Weight:

450.3

Molecular Formula:

C21H22Cl2FN5O

Molecular Weight:

450.3

Molecular Formula:

C21H22Cl2FN5O

Hydrogen Bond Donor Count:

2

Hydrogen Bond Acceptor Count:

6

Rotatable Bond Count:

5

Heavy Atom Count:

30

Complexity:

558

Crizotinib

877399-52-5

Xalkori

PF-02341066

(R)-crizotinib

PF-2341066

PF 2341066

(R)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)pyridin-2-amine

3-(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy-5-1-(4-piperidinyl)-1H-pyrazol-4-yl-2-pyridinamine

PF 02341066

Crizotinib (PF-02341066)

UNII-53AH36668S

PF2341066

CHEMBL601719

Crizotinib (PF-2341066)

CHEBI:64310

877399-52-5 (free base)

53AH36668S

3-(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy-5-1-(piperidin-4-yl)-1H-pyrazol-4-ylpyridin-2-amine

3-(1r)-1-(2,6-Dichloro-3-Fluorophenyl)ethoxy-5-(1-Piperidin-4-Yl-1h-Pyrazol-4-Yl)pyridin-2-Amine

3-(1R)-1-(2,6-DICHLORO-3-FLUOROPHENYL)ETHOXY-5-1-(4-PIPERIDINYL)-1H-PYRAZOL-4-YLPYRIDIN-2-AMINE

(R)-3-1-(2,6-Dichloro-3-fluoro-phenyl)-ethoxy-5-(1-piperidin-4-yl-1H-pyrazol-4-yl)-pyridin-2-ylamine

Xalkori (TN)

C21H22Cl2FN5O

Crizotinib USAN:INN

crizotinibum

VGH

Crizotinib- Bio-X

PF02341066

SCHEMBL93829

PF-2341066,Crizotinib

cc-190

Crizotinib (JAN/USAN/INN)

GTPL4903

QCR-32

Crizotinib, >=98% (HPLC)

PF-2341066 (Crizotinib)

PF-2341066 - Crizotinib

AOB2688

EX-A096

SYN1139

PF-02341066 (Crizotinib)

BCPP000116

DTXSID701009329

3-(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy-5-(1-piperidin-4-ylpyrazol-4-yl)pyridin-2-amine

AMY10313

Crizotinib

877399-52-5

Xalkori

PF-02341066

(R)-crizotinib

More...