Compound Summary
CGP 57380
Compound Information
CGP 57380
Compound Name: | CGP 57380 |
Compound CID: | 11644425 |
Synonyms: | CGP 57380 522629-08-9 CGP-57380 MNK1 Inhibitor N3-(4-fluorophenyl)-1h-pyrazolo3,4-dpyrimidine-3,4-diamine More... |
Iupac Name: | 3-N-(4-fluorophenyl)-2H-pyrazolo[3,4-d]pyrimidine-3,4-diamine |
InChI: | InChI=1S/C11H9FN6/c12-6-1-3-7(4-2-6)16-11-8-9(13)14-5-15-10(8)17-18-11/h1-5H,(H4,13,14,15,16,17,18) |
InChIKey: | UQPMANVRZYYQMD-UHFFFAOYSA-N |
Canonical Smiles: | C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F |
Isomeric Smiles: | C1=CC(=CC=C1NC2=C3C(=NC=NC3=NN2)N)F |
Molecular Weight: | 244.23 |
Molecular Formula: | C11H9FN6 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
CGP 57380
Molecular Weight: | 244.23 |
Molecular Formula: | C11H9FN6 |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 2 |
Heavy Atom Count: | 18 |
Complexity: | 283 |
Synonyms
CGP 57380
| CGP 57380 | CGP 57380 |
|---|---|
CGP 57380 |
522629-08-9 |
CGP-57380 |
MNK1 Inhibitor |
N3-(4-fluorophenyl)-1h-pyrazolo3,4-dpyrimidine-3,4-diamine |
CGP57380 |
3-N-(4-fluorophenyl)-2H-pyrazolo3,4-dpyrimidine-3,4-diamine |
CHEMBL1240885 |
C11H9FN6 |
SCHEMBL987991 |
GTPL6010 |
4-Amino-5-(4-fluoroanilino)-pyrazolo3,4-dpyrimidine |
SCHEMBL16714452 |
CHEBI:92749 |
DTXSID50469941 |
HMS3229K20 |
HMS3263L14 |
HMS3269P13 |
HMS3413D16 |
HMS3648M14 |
HMS3653G22 |
HMS3673K05 |
HMS3677D16 |
BCP27993 |
Tox21_501256 |
2314AH |
BDBM50130693 |
BDBM50298223 |
MFCD03861062 |
NSC741567 |
s7421 |
ZINC13816313 |
AKOS024457265 |
CCG-206868 |
LP01256 |
NSC 741567 |
NSC-741567 |
SDCCGSBI-0086774.P002 |
CGP57380;CGP-57380 |
NCGC00162380-01 |
NCGC00162380-02 |
NCGC00162380-03 |
NCGC00162380-06 |
NCGC00162380-09 |
NCGC00261941-01 |
AS-56092 |
QC-10494 |
AB0098119 |
B3570 |
MNK1 Inhibitor - CAS 522629-08-9 |
SW219758-1 |
CGP 57380, >=98% (HPLC) |
C75450 |
A902707 |
SR-02000000869 |
SR-02000000869-2 |
BRD-K42500029-001-01-9 |
Q27087429 |
N-(4-fluorophenyl)-3H-pyrazolo3,4-dpyrimidine-3,4-diamine |
3-N-(4-Fluorophenyl)-1H-pyrazolo3,4-dpyrimidine-3,4-diamine |
N3-(4-Fluorophenyl)-1H-pyrazolo-3,4-dpyrimidine-3,4-diamine |
Experimental Data
CGP 57380
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33.000000000000000 | umol/L | -7.000000000000000 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
CGP 57380
Statistics Data
CGP 57380
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -7.000000000000000 | 1 | 1 |
Statistics Data Visualization
CGP 57380
