Compound Summary
545380-34-5
Compound Information
545380-34-5
Compound Name: | 545380-34-5 |
Compound CID: | 509554 |
Synonyms: | 545380-34-5 QNZ EVP4593 6-Amino-4-(4-phenoxyphenylethylamino)quinazoline QNZ (EVP4593) More... |
Iupac Name: | 4-N-[2-(4-phenoxyphenyl)ethyl]quinazoline-4,6-diamine |
InChI: | InChI=1S/C22H20N4O/c23-17-8-11-21-20(14-17)22(26-15-25-21)24-13-12-16-6-9-19(10-7-16)27-18-4-2-1-3-5-18/h1-11,14-15H,12-13,23H2,(H,24,25,26) |
InChIKey: | IBAKVEUZKHOWNG-UHFFFAOYSA-N |
Canonical Smiles: | C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N |
Isomeric Smiles: | C1=CC=C(C=C1)OC2=CC=C(C=C2)CCNC3=NC=NC4=C3C=C(C=C4)N |
Molecular Weight: | 356.4 |
Molecular Formula: | C22H20N4O |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
545380-34-5
Molecular Weight: | 356.4 |
Molecular Formula: | C22H20N4O |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 27 |
Complexity: | 434 |
Synonyms
545380-34-5
| 545380-34-5 | 545380-34-5 |
|---|---|
545380-34-5 |
QNZ |
EVP4593 |
6-Amino-4-(4-phenoxyphenylethylamino)quinazoline |
QNZ (EVP4593) |
N4-(4-phenoxyphenethyl)quinazoline-4,6-diamine |
NF-kB activation inhibitor |
EVP-4593 |
4-N-2-(4-phenoxyphenyl)ethylquinazoline-4,6-diamine |
N4-2-(4-phenoxyphenyl)ethylquinazoline-4,6-diamine |
C22H20N4O |
NF-kappaB Activation Inhibitor |
EVP 4593 |
AG-F-89549 |
Curator_000005 |
InSolution™ NF-kappaB Activation Inhibitor |
6-amino-4-(4-phenoxyphenylethylamino) quinazoline |
SCHEMBL157421 |
CHEMBL522502 |
GTPL6012 |
QNZ(EVP4593) |
N4-2-(4-Phenoxyphenyl)ethyl-4,6-quinazolinediamine |
4,6-Quinazolinediamine, N4-2-(4-phenoxyphenyl)ethyl- |
DTXSID00333507 |
EX-A182 |
HMS3229K22 |
HMS3402B14 |
HMS3649N20 |
HMS3652J12 |
HMS3674K05 |
HMS3748A11 |
HMS3886M05 |
AMY24212 |
BCP07901 |
CAY10470 |
ZINC1489490 |
2022AH |
2676AH |
MFCD06411436 |
s4902 |
AKOS022175523 |
CCG-206870 |
CS-1515 |
LS41108 |
AC-32085 |
AS-67689 |
DA-42127 |
HY-13812 |
AB0165862 |
EVP4593, >=98% (HPLC) |
FT-0661997 |
SW220245-1 |
F17390 |
SR-01000946744 |
CU-00000000003-1 |
SR-01000946744-1 |
6-Amino-4-2-(4-phenoxyphenyl)ethylaminoquinazoline |
Q27087912 |
N~4~-2-(4-Phenoxyphenyl)ethylquinazoline-4,6-diamine |
Experimental Data
545380-34-5
| Species | Dose | Unit | Control(Avg days) | Treatment(Avg days) | Avg/Med Lifespan Change(%) | Control(Max days) | Treatment(Max days) | Max Lifespan Change(%) | Significant | Strain | Gender | PubMed | Avg/Med Lifespan Change tab |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 3.000000000000000 | mM | -4.000000000000000 | -4.000000000000000 | S | Canton-S | 24096697 | Inactive | |||||
| Drosophila melanogaster | 3.000000000000000 | mM | 2.000000000000000 | 0.000000000000000 | NS | Canton-S | 24096697 | Inactive | |||||
| Drosophila melanogaster | 0.030000000000000 | mM | -15.000000000000000 | -4.000000000000000 | S | Canton-S | 24096697 | Inactive | |||||
| Drosophila melanogaster | 0.300000000000000 | mM | -4.000000000000000 | -4.000000000000000 | S | Canton-S | 24096697 | Inactive | |||||
| Drosophila melanogaster | 0.300000000000000 | mM | 0.000000000000000 | 8.000000000000000 | NS | Canton-S | 24096697 | Inactive | |||||
| Drosophila melanogaster | 0.030000000000000 | mM | 2.000000000000000 | 4.000000000000000 | NS | Canton-S | 24096697 | Inactive |
Experimental Data Visualization
545380-34-5
Statistics Data
545380-34-5
| Species | Avg/Med Lifespan Change(%) | Max Lifespan Change(%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 2.000000000000000 | 8.000000000000000 | 1 | 6 |
Statistics Data Visualization
545380-34-5
