Compound Summary
Compound Information
DIOSGENIN
Compound Name: | DIOSGENIN |
Compound CID: | 99474 |
Synonyms: | DIOSGENIN 512-04-9 Nitogenin UNII-K49P2K8WLX (3beta,25R)-spirost-5-en-3-ol More... |
Iupac Name: | (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,16S)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-16-ol |
InChI: | InChI=1S/C27H42O3/c1-16-7-12-27(29-15-16)17(2)24-23(30-27)14-22-20-6-5-18-13-19(28)8-10-25(18,3)21(20)9-11-26(22,24)4/h5,16-17,19-24,28H,6-15H2,1-4H3/t16-,17+,19+,20-,21+,22+,23+,24+,25+,26+,27-/m1/s1 |
InChIKey: | WQLVFSAGQJTQCK-VKROHFNGSA-N |
Canonical Smiles: | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(CCC(C6)O)C)C)C)OC1 |
Isomeric Smiles: | C[C@@H]1CC[C@@]2([C@H]([C@H]3[C@@H](O2)C[C@@H]4[C@@]3(CC[C@H]5[C@H]4CC=C6[C@@]5(CC[C@@H](C6)O)C)C)C)OC1 |
Molecular Weight: | 414.6 |
Molecular Formula: | C27H42O3 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
DIOSGENIN
Molecular Weight: | 414.6 |
Molecular Formula: | C27H42O3 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 0 |
Heavy Atom Count: | 30 |
Complexity: | 746 |
Synonyms
DIOSGENIN
| DIOSGENIN | DIOSGENIN |
|---|---|
DIOSGENIN |
512-04-9 |
Nitogenin |
UNII-K49P2K8WLX |
(3beta,25R)-spirost-5-en-3-ol |
Spirost-5-en-3-ol, (3b,25R)- |
(20R,25R)-Spirost-5-en-3beta-ol |
K49P2K8WLX |
CHEBI:4629 |
(25R)-spirost-5-en-3beta-diol |
MFCD00016887 |
NSC 33396 |
Spirost-5-en-3-beta-ol, (25R)- |
(25R)-14beta,17beta-spirost-5-en-3beta-ol |
(25R)-Spirost-5-en-3beta-ol |
SP 37 |
C27H42O3 |
(2R,4S,5R,6aR,6bS,8aS,8bR,9S,11aS,12aS,12bS)-5,6a,8a,9-Tetramethyl-1,3,3,4,4,5,5,6,6a,6b,6,7,8,8a,8b,9,11a,12,12a,12b-icosahydrospironaphtho2,1:4,5indeno2,1-bfuran-10,2-pyran-4-ol |
3beta-Hydroxy-5-spirostene |
nitrogen in |
CCRIS 6803 |
22alpha-Spirost-5-en-3beta-ol |
Dioscorea sapogenin |
Diosgenin,(S) |
(7S,8S,10S,13S,15S,18S,22S,3R,12R,14R,19R)-3,13,15,19-tetramethyl-11-oxaspiro 2H-3,4,5,6-tetrahydropyran-6,6-pentacyclo10.8.0.0<2,9>.0<4,8>.0<13,18>icosa ne-24-en-22-ol |
YUV |
EINECS 208-134-3 |
DISOGENIN |
BRN 0094582 |
Diosgenin, >=93% |
3A-Hydroxy-5-spirostene |
SCHEMBL83359 |
5-19-03-00030 (Beilstein Handbook Reference) |
(25R)-5-Spirosten-3A-ol |
CHEMBL412437 |
(25R)-5-Spirosten-3beta-ol |
DTXSID00895074 |
(25R)-Spirost-5-en-3.beta-ol |
HY-N0177 |
ZINC6857614 |
LMST01080037 |
SBB058140 |
AKOS015961083 |
ACN-034765 |
CS-5303 |
MCULE-6739922044 |
NCGC00386027-01 |
Spirost-5-en-3-ol, (3-beta,25R)- |
AS-13640 |
ST097775 |
AB0090307 |
N1715 |
S2291 |
Spirost-5-en-3beta-ol, (25R)- (8CI) |
C08898 |
J10028 |
M03858 |
Spirost-5-en-3-ol, (3beta,25R)- (9CI) |
512D049 |
Q-100574 |
Q1107734 |
BRD-K28690501-001-02-1 |
Diosgenin, European Pharmacopoeia (EP) Reference Standard |
UNII-5E5W122QCR component WQLVFSAGQJTQCK-VKROHFNGSA-N |
(2R,5R)-5-tetramethylspiro?-2,2-tetrahydropyranol |
NCGC00386027-01_C27H42O3_Spirost-5-en-3-ol, (3beta,25R)- |
Experimental Data
DIOSGENIN
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 5 | ug/mL | 11.9 | 13 | 9.8 | S | N2 | 28954389 | Active | ||||
| Caenorhabditis elegans | 50 | ug/mL | 11.9 | 14.3 | 20.1 | S | N2 | 28954389 | Active | ||||
| Caenorhabditis elegans | 10 | ug/mL | 11.9 | 13.6 | 14.8 | S | N2 | 28954389 | Active |
Experimental Data Visualization
DIOSGENIN
Statistics Data
DIOSGENIN
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 20.1 | 1 | 3 |
Statistics Data Visualization
DIOSGENIN
