Compound Summary

  Compound Information
 curcumin

Compound Name:

curcumin

Compound CID:

969516

Synonyms:

curcumin

458-37-7

Diferuloylmethane

Natural yellow 3

Turmeric yellow

More...

Iupac Name:

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

InChI:

InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+

InChIKey:

VFLDPWHFBUODDF-FCXRPNKRSA-N

Canonical Smiles:

COC1=C(C=CC(=C1)C=CC(=O)CC(=O)C=CC2=CC(=C(C=C2)O)OC)O

Isomeric Smiles:

COC1=C(C=CC(=C1)/C=C/C(=O)CC(=O)/C=C/C2=CC(=C(C=C2)O)OC)O

Molecular Weight:

368.4

Molecular Formula:

C21H20O6

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 curcumin

Molecular Weight:

368.4

Molecular Formula:

C21H20O6

Hydrogen Bond Donor Count:

2

Hydrogen Bond Acceptor Count:

6

Rotatable Bond Count:

8

Heavy Atom Count:

27

Complexity:

507

  Synonyms
 curcumin

curcumin curcumin

curcumin

458-37-7

Diferuloylmethane

Natural yellow 3

Turmeric yellow

Turmeric

Indian saffron

Curcuma

Kacha haldi

Gelbwurz

Curcumin I

Souchet

Haidr

Halad

Haldar

Halud

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Merita earth

Terra Merita

Yellow Ginger

Yellow Root

Safran dInde

Yo-Kin

Curcuma oil

Golden seal

Orange Root

C.I. Natural Yellow 3

Curcumine

Hydrastis

Indian turmeric

Yellow puccoon

Diferaloylmethane

Turmeric oleoresin

Kurkumin Czech

Tumeric yellow

CI Natural Yellow 3

Zlut prirodni 3 Czech

Cucurmin

C.I. 75300

Tumeric oleoresin

8024-37-1

Curcumin (synthetic)

E 100

Curcurmin

1,7-Bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

NSC32982

UNII-IT942ZTH98

MFCD00008365

NSC 32982

Turmeric (>98% curcurmin)

CHEBI:3962

MLS000069631

Turmeric oleoresin (79%-85% curcumin)

CI 75300

Turmeric extract

Oils, curcuma

1,9-Bis(4-hydroxy-3-methoxyphenyl)-2,7-nonadiene-4,6-dione

CHEMBL140

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)-

SMR000058237

1,6-Heptadiene-3,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-

IT942ZTH98

1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Turmeric oil

Oil of turmeric

(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

NSC-32982

NSC687842

Curcuma longa oils

94875-80-6

NCGC00017159-05

Kurkumin

DSSTox_CID_1421

(1E,6E)-1,7-bis(4-hydroxy-3-methoxy-phenyl)hepta-1,6-diene-3,5-dione

(1E,6E)-1,7-bis4-hydroxy-3-(methyloxy)phenylhepta-1,6-diene-3,5-dione

Zlut prirodni 3

Turmeric root oil

DSSTox_RID_78861

DSSTox_GSID_31077

Turmeric, oleoresin

Curcuma oil (Curcuma longa)

Turmeric oil (Curcuma longa L.)

Curcuma longa l. root oil

CAS-458-37-7

FEMA No. 3085

FEMA No. 3086

CCRIS 3257

CCRIS 5804

HSDB 4334

1,5-Di(vanillyliden)acetylaceton

NCI-C61325

SR-01000000149

1,5-Divanillyliden-2,4-pentandion

EINECS 207-280-5

NSC 687842

BRN 2306965

diferuloylmethan

E 100 (Dye)

Curcumin solution

Haldar, Souchet

Turmeric; Curcuma

Curcumin,(S)

trans,trans-Curcumin

Opera_ID_1627

SCHEMBL8440

SCHEMBL8441

Curcumin, analytical standard

4-08-00-03697 (Beilstein Handbook Reference)

MLS001148449

BIDD:ER0479

CU-01000001305-2

turmeric root oil CO2 extract

cid_969516

GTPL7000

turmeric root oil hydrodistilled

DTXSID8031077

SCHEMBL13521974

BDBM29532

cid_5281767

cMAP_000052

HMS2233K04

HMS3649K06

ZINC899824

2,7-Nonadiene-4,6-dione, 1,9-bis(4-hydroxy-3-methoxyphenyl)-

91884-86-5

AMY33436

BCP04695

HY-N0005

Tox21_110803

Tox21_111505

Tox21_201116

BBL027711

BDBM50067040

BDBM50140172

CC0179

CCG-36020

CCG-36107

SBB006495

STL371943

AKOS001305497

BCP9000557

CS-1490

curcuma longa l. root oil CO2 extract

DB11672

curcuma longa l. root oil hydrodistilled

NCGC00017159-04

NCGC00017159-06

NCGC00017159-07

NCGC00017159-09

NCGC00017159-10

NCGC00017159-11

NCGC00017159-12

NCGC00023332-03

NCGC00023332-04

NCGC00023332-05

NCGC00258668-01

AC-24238

AS-72202

BP-25396

M212

ST055629

BCP0726000035

DB-002681

WLN: 1OR BQ E1U1V1V1U1R DQ CO1

C-230

N1839

1,3-Di(3-methoxy-4-hydroxystyryl)propanedial

1790-EP2305629A1

1790-EP2308861A1

F21478

J10108

K00009

Curcumin, Curcuma longa L. - CAS 458-37-7

Curcumin, from Curcuma longa (Turmeric), powder

458C377

A826902

Curcumin, primary pharmaceutical reference standard

Q312266

1,5-dione, 1,7-bis(4-hydroxy-3-methoxyphenyl)-

SR-01000000149-2

SR-01000000149-5

BRD-K07572174-001-02-2

BRD-K07572174-001-19-6

BRD-K07572174-001-22-0

Curcumin, >=94% (curcuminoid content), >=80% (Curcumin)

1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadien-3,5-dione

1,7-bis(4-hydroxy-3-methoxyphenyl)1,6-heptadiene-3,5-dione

Curcumin, (total curcuminoid content), from Turmeric rhizome

Curcumin, matrix substance for MALDI-MS, >=99.5% (HPLC)

Curcumin, United States Pharmacopeia (USP) Reference Standard

1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione

1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

((E,E)-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione)

(1E,6E)-1,7-bis(3-methoxy-4-oxidanyl-phenyl)hepta-1,6-diene-3,5-dione

(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione #

(1E,6E)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione.

(1E,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione

(1Z,6E)-1,7-Bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione

1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, (E,E)-

5-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-1,4,6-heptatrien-3-one

5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one

Curcumin; 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

(1E,4Z,6E)-5-Hydroxy-1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,4,6-trien-3-one

(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (Synthetic)

Curcumin solution, ~0.1 % (w/v) (in ethanol with 2M HCl (99:1 v/v)), for TLC derivatization
  Experimental Data
 curcumin

Species Dosage Unit CG Lifespan(AVG/MED days) TG Lifespan(AVG/MED days) Lifespan Change(AVG/MED%) CG Lifespan(MAX days) TG Lifespan(MAX days) Lifespan Change(MAX%) Significant Strain Gender PubMed Active Label
Caenorhabditis elegans 100 mM 15.44 17.39 12.62 18 23 27.77 S N2 27810360 Active
Drosophila melanogaster 200 mM 0 NS Ra 23063786 Inactive
Apis mellifera 1 ug/mL 0 NS 34580381 Inactive
Drosophila melanogaster 100 mM 0 S Ra 23063786 Active
Drosophila melanogaster 10 mM 0 NS Ra 23063786 Inactive
Apis mellifera 100 ug/mL 0 S 34580381 Active
Apis mellifera 10 ug/mL 0 NS 34580381 Inactive
Caenorhabditis elegans 10 umol/L Unclear N2 33683565
Caenorhabditis elegans 20 umol/L Unclear N2 33683565
Caenorhabditis elegans 200 umol/L Unclear N2 33683565
Caenorhabditis elegans 100 umol/L Unclear N2 33683565
Drosophila melanogaster 0.5 mg 30 33 10 58 55 -5.1 NS Oregon-R MALES 22653297 Inactive
Drosophila melanogaster 100 umol/L 19 S FEMALES 20645870 Active
Drosophila melanogaster 0.2 mg/g 35.6 38 0.07 57 62 0.09 S Canton-S FEMALES 30488487 Active
Drosophila melanogaster 1 mg 23 24 4.6 54 61 13 S Oregon-R FEMALES 22653297 Active
Caenorhabditis elegans 20 umol/L 15.5 16.6 0.07 27 25 -0.07 NS N2 31534071 Inactive
Caenorhabditis elegans 100 umol/L 17.08 16.24 -4.893 NS N2 33008901 Inactive
Drosophila melanogaster 0.2 mg/g 36.5 37.6 0.03 61 64 0.05 NS Canton-S MALES 30488487 Inactive
Drosophila melanogaster 100 mM 46.8 38 S FEMALES 26136617 Active
Drosophila melanogaster 1 mg 30 38 26.7 58 55 -5.1 S Oregon-R MALES 22653297 Active
Caenorhabditis elegans 100 umol/L 15 16 6.25 NS N2 29263362 Inactive
Drosophila melanogaster 0.5 mg 23 26 13 54 53 -1.9 S Oregon-R FEMALES 22653297 Active
Drosophila melanogaster 10 mM 27.14 32.34 0.19 57 65 0.14 S Canton-S 25173182 Active
Drosophila melanogaster 0.5 g/L 51 49 -0.04 NS MALES 33951964 Inactive
Drosophila melanogaster 100 mM -23.4 S FEMALES 26136617 Inactive
Drosophila melanogaster 5 mM 27.14 27.68 0.02 57 53 -0.07 S Canton-S 25173182 Active
Caenorhabditis elegans 20 umol/L 20.1 25.4 0.26 30 33 0.1 S N2 31534071 Active
Caenorhabditis elegans 200 umol/L 8.4 8.8 0.05 NS N2 21855561 Inactive
Drosophila melanogaster 100 mM -17 -3 S FEMALES 26136617 Inactive
Drosophila melanogaster 10 mM 33.77 45.37 0.34 76 95 0.25 S Canton-S 25173182 Active
Drosophila melanogaster 2 g/L 51 58 0.14 S MALES 33951964 Active
Mus musculus 2000 kg/mg 786 808 0.03 NS UM-HET3 MALES 22451473 Inactive
Caenorhabditis elegans 20 umol/L 8.4 11.7 0.39 S N2 21855561 Active
Caenorhabditis elegans 10 umol/L 16.74 15.55 -7.106 NS N2 33008901 Inactive
Drosophila melanogaster 5 mM 33.77 35.67 0.06 76 88 0.16 S Canton-S 25173182 Active
Drosophila melanogaster 25 mM 27.14 28.21 0.04 57 61 0.07 S Canton-S 25173182 Active
Drosophila melanogaster 250 umol/L 16 S MALES 20645870 Active
Drosophila melanogaster 50 mM 33.77 34.86 0.03 76 89 0.17 S Canton-S 25173182 Active
Caenorhabditis elegans 100 umol/L 22.54 15.07 Unclear N2 33683565
Drosophila melanogaster 50 mM 27.14 26.81 -0.01 57 59 0.04 S Canton-S 25173182 Inactive
Drosophila melanogaster 100 mM 25.5 0 S FEMALES 26136617 Active
Drosophila melanogaster 200 umol/L 44.8 44.81 0.01429 NS MALES 33008901 Inactive
Drosophila melanogaster 0.5 g/L 61 63 0.03 NS FEMALES 33951964 Inactive
Drosophila melanogaster 25 mM 33.77 36.99 0.1 76 95 0.25 S Canton-S 25173182 Active
Drosophila melanogaster 1 mg 63.9 76.9 0.2 S Wild 1-A 23675008 Active
Drosophila melanogaster 20 umol/L 45.44 46.53 2.407 NS FEMALES 33008901 Inactive
Caenorhabditis elegans 0.05 ug/mL 11 11.5 0.05 19 20 0.05 NS N2 29550283 Inactive
Mus musculus 2000 kg/mg 866 905 0.05 NS UM-HET3 FEMALES 22451473 Inactive
Caenorhabditis elegans 100 umol/L 17.3 21.2 0.23 27.2 31.3 0.15 NS N2 25959406 Inactive
Drosophila melanogaster 1 g/L 51 52 0.02 NS MALES 33951964 Inactive
Drosophila melanogaster 2 g/L 61 68 0.11 S FEMALES 33951964 Active
Drosophila melanogaster 1 g/L 61 66 0.08 S FEMALES 33951964 Active
  Experimental Data Visualization
 curcumin

  Statistics Data
 curcumin

Species Lifespan Change(AVG/MED%) Lifespan Change(MAX%) Count Reference Count Data point
Apis mellifera 0 1 3
Caenorhabditis elegans 22.54 27.77 8 15
Drosophila melanogaster 46.8 38 9 32
Mus musculus 0.05 1 2
  Statistics Data Visualization
 curcumin

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