Compound Summary
Compound Information
clarithromycin
Compound Name: | clarithromycin |
Compound CID: | 84029 |
Synonyms: | clarithromycin 81103-11-9 Biaxin 6-O-Methylerythromycin Klaricid More... |
Iupac Name: | (3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-14-ethyl-12,13-dihydroxy-4-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
InChI: | InChI=1S/C38H69NO13/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,47-14)33(52-35-29(41)25(39(11)12)16-20(3)48-35)22(5)30(23(6)34(44)50-26)51-27-18-36(8,46-13)32(43)24(7)49-27/h19-27,29-33,35,41-43,45H,15-18H2,1-14H3/t19-,20-,21+,22+,23-,24+,25+,26-,27+,29-,30+,31-,32+,33-,35+,36-,37-,38-/m1/s1 |
InChIKey: | AGOYDEPGAOXOCK-KCBOHYOISA-N |
Canonical Smiles: | CCC1C(C(C(C(=O)C(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
Isomeric Smiles: | CC[C@@H]1[C@@]([C@@H]([C@H](C(=O)[C@@H](C[C@@]([C@@H]([C@H]([C@@H]([C@H](C(=O)O1)C)O[C@H]2C[C@@]([C@H]([C@@H](O2)C)O)(C)OC)C)O[C@H]3[C@@H]([C@H](C[C@H](O3)C)N(C)C)O)(C)OC)C)C)O)(C)O |
Molecular Weight: | 748 |
Molecular Formula: | C38H69NO13 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
clarithromycin
Molecular Weight: | 748 |
Molecular Formula: | C38H69NO13 |
Hydrogen Bond Donor Count: | 4 |
Hydrogen Bond Acceptor Count: | 14 |
Rotatable Bond Count: | 8 |
Heavy Atom Count: | 52 |
Complexity: | 1190 |
Synonyms
clarithromycin
| clarithromycin | clarithromycin |
|---|---|
clarithromycin |
81103-11-9 |
Biaxin |
6-O-Methylerythromycin |
Klaricid |
6-O-Methylerythromycin a |
Clarithromycine |
Clathromycin |
Abbott-56268 |
A-56268 |
Macladin |
Clarith |
Klacid |
Kofron |
Veclam |
Clarithromycinum |
Naxy |
TE-031 |
Erythromycin, 6-O-methyl- |
Biaxin XL |
UNII-H1250JIK0A |
Clarithromycin identity |
C38H69NO13 |
TE031 |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione |
Prevpac |
CHEBI:3732 |
H1250JIK0A |
Claritromicina |
Abbotic |
Astromen |
Bicrolid |
Clacine |
Clambiotic |
Claribid |
Claricide |
Claridar |
Claripen |
Fromilid |
Heliclar |
Klaciped |
Mabicrol |
Clacee |
Clacid |
Clarem |
Crixan |
Cyllid |
Klabax |
Klarid |
Klarin |
Maclar |
Zeclar |
Helas |
Mavid |
Adel |
Biaxin filmtab |
Klax |
Biaxin HP |
Biaxin xl filmtab |
Klaricid Pediatric |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yloxy-14-ethyl-12,13-dihydroxy-4-(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yloxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
CLA |
Clarithromycin extended release |
DRG-0099 |
Klaricid H.P. |
CTY |
SMR000466382 |
Clarithromycine INN-French |
Clarithromycinum INN-Latin |
Claritromicina INN-Spanish |
SR-05000001992 |
Clarithromycin (Biaxin, Klacid) |
clarithromycina |
Cyllind |
CCRIS 8833 |
Klaricid XL |
HSDB 8055 |
(14R)-14-Hydroxyclarithromycin |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yloxy-14-ethyl-12,13-dihydroxy-4-(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dione |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yloxy-14-ethyl-12,13-dihydroxy-4-(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yloxy-7-methoxy |
Clarithromycin,(S) |
Biaxin (TN) |
Spectrum_000089 |
CPD000466382 |
Clarithromycin USAN:USP:INN:BAN:JAN |
SpecPlus_000559 |
6-O-methyl erythromycin |
O(6)-methylerythromycin |
CLA; |
Spectrum2_001668 |
Spectrum3_001667 |
Spectrum4_000629 |
Spectrum5_001729 |
6-0-methylerythromycin A |
A56268 |
CHEMBL1741 |
SCHEMBL38125 |
BSPBio_003453 |
KBioGR_001218 |
KBioSS_000509 |
MLS000759516 |
MLS001201751 |
MLS001424066 |
BIDD:GT0200 |
DivK1c_006655 |
SPECTRUM1504231 |
SPBio_001855 |
Lactoferrin B & Clarithromycin |
Lactoferrin H & Clarithromycin |
DTXSID3022829 |
Clarithromycin & Interleukin-12 |
CLM & IL-12 |
GTPL10903 |
KBio1_001599 |
KBio2_000509 |
KBio2_003077 |
KBio2_005645 |
KBio3_002673 |
ANX-015 |
SDP-015 |
Clarithromycin (JP17/USP/INN) |
Clarithromycin, >=95% (HPLC) |
Clarithromycin, >=98% (HPLC) |
HMS1922H09 |
HMS2051G18 |
HMS2090O11 |
HMS2094M05 |
HMS2231A08 |
HMS3715J17 |
Pharmakon1600-01504231 |
EBD13493 |
BDBM50404044 |
CCG-39086 |
LMPK04000014 |
MFCD00865140 |
NSC758704 |
s2555 |
ZINC85534098 |
AKOS015894242 |
CS-2576 |
DB01211 |
MCULE-7168853332 |
NC00140 |
NSC 758704 |
NSC-758704 |
NCGC00178054-01 |
NCGC00178054-06 |
H781 |
HY-17508 |
SBI-0206716.P001 |
Clarithromycin 100 microg/mL in Acetonitrile |
C06912 |
D00276 |
F14975 |
J10130 |
AB00053394-10 |
AB00053394-12 |
AB00053394-13 |
AB00053394_14 |
AB00053394_15 |
103C119 |
A840042 |
Q118551 |
Q-200870 |
SR-05000001992-1 |
SR-05000001992-2 |
BRD-K49668410-001-07-1 |
BRD-K49668410-001-18-8 |
Clarithromycin, European Pharmacopoeia (EP) Reference Standard |
Clarithromycin, United States Pharmacopeia (USP) Reference Standard |
Clarithromycin Identity, United States Pharmacopeia (USP) Reference Standard |
Clarithromycin, Ready Made Solution, 50 mg/mL in DMSO, 0.2 mum filtered |
Clarithromycin for peak identification, European Pharmacopoeia (EP) Reference Standard |
Clarithromycin, Pharmaceutical Secondary Standard; Certified Reference Material |
(3R,4S,5R,6R,7R,9R,11R,12R,13S,14R)-6-(2S,3R,4R,6R)-4-(dimethylamino)-3-hydroxy-6-methyl-tetrahydropyran-2-yloxy-14-ethyl-12,13-dihydroxy-4-(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyl-tetrahydropyran-2-yloxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacy |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-((2S,3R,4S,6R)-4-(Dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy)-14-ethyl-12,13-dihydroxy-4-((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yloxy)-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yloxy-14-ethyl-12,13-dihydroxy-4-(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yloxy-7-methoxy-3,5,7,9,11,13-hexamethyl-oxacyclotetradecane-2,10-dion |
(3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-6-{(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yloxy}-14-ethyl-12,13-dihydroxy-4-{(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yloxy}-7-methoxy-3,5,7,9,11,13-hexamethyloxacyclotetradecane-2,10-dione (non-preferred name) |
(3R,4S,5S,6R,7R,9R,11S, 12R,13S,14S)-6-{(2S,3R,4S,6R)- 4-dimethylamino-3-hydroxy-6-methyloxan-2-yloxy}-14-ethyl-12,13-dihydroxy- 4-{(2R,4S,5S,6S)-5-hydroxy-4-methoxy-4,6- dimethyloxan-2-yloxy}-7-methoxy-3,5,7,9,11,13-hexamethyl-1- oxacyclotetradecane-2,10-dione |
Experimental Data
clarithromycin
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Brachionus manjavacas | 1 | umol/L | 67 | S | B. manjavacas | 29340835 | Active |
Experimental Data Visualization
clarithromycin
Statistics Data
clarithromycin
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Brachionus manjavacas | 67 | 1 | 1 |
Statistics Data Visualization
clarithromycin
