Compound Summary
Compound Information
4272-74-6
Compound Name: | 4272-74-6 |
Compound CID: | 73093 |
Synonyms: | 4272-74-6 TLCK hydrochloride (S)-N-(7-Amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride N-alpha-p-Tosyl-L-lysine chloromethyl ketone hydrochloride TLCK More... |
Iupac Name: | N-[(3S)-7-amino-1-chloro-2-oxoheptan-3-yl]-4-methylbenzenesulfonamide;hydrochloride |
InChI: | InChI=1S/C14H21ClN2O3S.ClH/c1-11-5-7-12(8-6-11)21(19,20)17-13(14(18)10-15)4-2-3-9-16;/h5-8,13,17H,2-4,9-10,16H2,1H3;1H/t13-;/m0./s1 |
InChIKey: | YFCUZWYIPBUQBD-ZOWNYOTGSA-N |
Canonical Smiles: | CC1=CC=C(C=C1)S(=O)(=O)NC(CCCCN)C(=O)CCl.Cl |
Isomeric Smiles: | CC1=CC=C(C=C1)S(=O)(=O)N[C@@H](CCCCN)C(=O)CCl.Cl |
Molecular Weight: | 369.3 |
Molecular Formula: | C14H22Cl2N2O3S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
4272-74-6
Molecular Weight: | 369.3 |
Molecular Formula: | C14H22Cl2N2O3S |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 9 |
Heavy Atom Count: | 22 |
Complexity: | 414 |
Synonyms
4272-74-6
| 4272-74-6 | 4272-74-6 |
|---|---|
4272-74-6 |
TLCK hydrochloride |
(S)-N-(7-Amino-1-chloro-2-oxoheptan-3-yl)-4-methylbenzenesulfonamide hydrochloride |
N-alpha-p-Tosyl-L-lysine chloromethyl ketone hydrochloride |
TLCK |
(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride |
Na-p-Tosyl-L-lysine chloromethyl ketone hydrochloride |
4238-41-9 |
(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone HCl |
N-alpha-Tosyl-L-lysine chloromethyl ketone hydrochloride |
NCGC00094434-01 |
DSSTox_CID_25807 |
DSSTox_RID_81145 |
N-(3S)-7-amino-1-chloro-2-oxoheptan-3-yl-4-methylbenzenesulfonamide;hydrochloride |
DSSTox_GSID_45807 |
Tos-Lys-chloromethylketone HCl |
CAS-4272-74-6 |
SR-01000076171 |
EINECS 224-266-4 |
EINECS 224-199-0 |
Tosyl-L-lysyl-chloromethane hydrochloride |
Tosyllysine chloromethylketone hydrochloride |
L-N-(5-Amino-1-(chloroacetyl)pentyl)-p-toluenesulfonamide hydrochloride |
p-Toluenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-, hydrochloride, L- |
Tosyl-L-lysine chloromethylketone hydrochloride |
(S)-N-(5-Amino-1-(chloroacetyl)pentyl)-4-methylbenzenesulfonamide monohydrochloride |
Benzenesulfonamide, N-(5-amino-1-(chloroacetyl)pentyl)-4-methyl-, monohydrochloride, (S)- |
MLS000859917 |
C14H22Cl2N2O3S |
CHEMBL1256974 |
DTXSID3045807 |
SCHEMBL11406948 |
p-N-(7-Amino-1-chloro-2-oxohept-3-yl)toluenesulphonamide |
Tox21_111280 |
Tox21_501180 |
MFCD00065395 |
AKOS024319626 |
AKOS024465073 |
Tox21_111280_1 |
CCG-207871 |
LP01180 |
NSC 727366 |
(S)-N-(5-Amino-1-(chloroacetyl)pentyl)-p-toluenesulphonamide monohydrochloride |
NCGC00162359-04 |
NCGC00261865-01 |
AS-46909 |
SMR000326778 |
HY-112716 |
CS-0062851 |
EU-0101180 |
X6888 |
F10889 |
T 7254 |
A872832 |
SR-01000076171-1 |
SR-01000076171-5 |
Nalpha-Tosyl-L-lysine chloromethyl ketone hydrochloride |
1-Chloro-3-tosylamido-7-amino-2-hepta none hydrochloride |
(3S)-1-Chloro-3-tosylamido-7-amino-2-heptanone hydrochloride, 98% |
Benzenesulfonamide,N-(1S)-5-amino-1-(2-chloroacetyl)pentyl-4-methyl- |
N-alpha-(p-Toluenesulfonyl)-L-lysine chloromethyl ketone hydrochloride |
Nalpha-Tosyl-L-lysine chloromethyl ketone hydrochloride, >=99.0% (AT) |
Nalpha-Tosyl-L-lysine chloromethyl ketone hydrochloride, >=96% (TLC), powder |
Experimental Data
4272-74-6
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | -13 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
4272-74-6
Statistics Data
4272-74-6
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -13 | 1 | 1 |
Statistics Data Visualization
4272-74-6
