Compound Summary
Compound Information
Nebivolol
Compound Name: | Nebivolol |
Compound CID: | 71301 |
Synonyms: | Nebivolol 99200-09-6 2,2-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol) 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethylaminoethanol R 67145 More... |
Iupac Name: | 1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol |
InChI: | InChI=1S/C22H25F2NO4/c23-15-3-7-19-13(9-15)1-5-21(28-19)17(26)11-25-12-18(27)22-6-2-14-10-16(24)4-8-20(14)29-22/h3-4,7-10,17-18,21-22,25-27H,1-2,5-6,11-12H2 |
InChIKey: | KOHIRBRYDXPAMZ-UHFFFAOYSA-N |
Canonical Smiles: | C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O |
Isomeric Smiles: | C1CC2=C(C=CC(=C2)F)OC1C(CNCC(C3CCC4=C(O3)C=CC(=C4)F)O)O |
Molecular Weight: | 405.4 |
Molecular Formula: | C22H25F2NO4 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Nebivolol
Molecular Weight: | 405.4 |
Molecular Formula: | C22H25F2NO4 |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 7 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 29 |
Complexity: | 483 |
Synonyms
Nebivolol
| Nebivolol | Nebivolol |
|---|---|
Nebivolol |
99200-09-6 |
2,2-Azanediylbis(1-(6-fluorochroman-2-yl)ethanol) |
1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethylaminoethanol |
R 67145 |
CHEBI:64019 |
Nebivololum Latin |
2,2-iminobis1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol |
R 065824 |
118457-14-0 |
(-)-Nebivolol; Levonebivolol; l-Nebivolol |
R65,824 |
R 67138;d-Nebivolol;(+)-Nebivolol; (S,R,R,R)-Nebivolol |
R-65824 |
Narbivolol |
Nebivolol-d4 |
ACMC-20dgjc |
rac Nebivolol-d8 |
2H-1-Benzopyran-2-methanol, alpha,alpha-(iminobis(methylene))bis(6-fluoro-3,4-dihydro- |
SCHEMBL19863 |
CHEMBL434394 |
GTPL7246 |
DTXSID9040556 |
BDBM84735 |
HMS3604L09 |
2H-1-Benzopyran-2-methanol,a,a-iminobis(methylene)bis6-fluoro-3,4-dihydro-, (aS,aS,2R,2S)- |
MFCD00865796 |
NSC_71301 |
PDSP1_000244 |
PDSP2_000243 |
Ro-67555 |
AKOS015895102 |
AC-1611 |
CCG-357228 |
DB04861 |
VA11364 |
AS-77015 |
CAS_99200-09-6 |
DB-057766 |
FT-0631000 |
FT-0672663 |
FT-0672664 |
FT-0672665 |
FT-0672666 |
FT-0700072 |
R74714 |
200N096 |
A845981 |
L001284 |
Q418130 |
SR-01000883933 |
SR-01000883933-1 |
2,2-iminobis1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol |
alpha,alpha-(iminodimethylene)bis-(6-fluoro-2-chromanmethanol)" |
1,1-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2-iminodiethanol" |
1,1-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)-2,2-iminodiethanol |
1-(6-fluorochroman-2-yl)-2-2-(6-fluorochroman-2-yl)-2-hydroxyethylaminoethanol |
alpha,alpha-(iminobismethylene)bis-(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol)" |
alpha,alpha-iminobis(methylene)bis6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol" |
alpha,alphaiminobis(methylene)bis6-fluoro-3,4-dihydro-2H-1-benzopyran-2-methanol" |
Experimental Data
Nebivolol
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mus musculus | 0.27 | g/kg | 983 | 1046 | 6.4 | S | C3B6F1 | MALES | 23314750 | Active |
Experimental Data Visualization
Nebivolol
Statistics Data
Nebivolol
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Mus musculus | 6.4 | 1 | 1 |
Statistics Data Visualization
Nebivolol
