Compound Summary
Compound Information
Trifluoperazine dihydrochloride
Compound Name: | Trifluoperazine dihydrochloride |
Compound CID: | 66064 |
Synonyms: | Trifluoperazine dihydrochloride 440-17-5 Trifluoperazine hydrochloride Trifluoperazine 2HCl Stelazine More... |
Iupac Name: | 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;dihydrochloride |
InChI: | InChI=1S/C21H24F3N3S.2ClH/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24;;/h2-3,5-8,15H,4,9-14H2,1H3;2*1H |
InChIKey: | BXDAOUXDMHXPDI-UHFFFAOYSA-N |
Canonical Smiles: | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl |
Isomeric Smiles: | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F.Cl.Cl |
Molecular Weight: | 480.4 |
Molecular Formula: | C21H26Cl2F3N3S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Trifluoperazine dihydrochloride
Molecular Weight: | 480.4 |
Molecular Formula: | C21H26Cl2F3N3S |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 7 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 30 |
Complexity: | 510 |
Synonyms
Trifluoperazine dihydrochloride
| Trifluoperazine dihydrochloride | Trifluoperazine dihydrochloride |
|---|---|
Trifluoperazine dihydrochloride |
440-17-5 |
Trifluoperazine hydrochloride |
Trifluoperazine 2HCl |
Stelazine |
Terfluzine |
Trifluoperazine HCl |
Triphthazine |
Eskazinyl |
Jatroneural |
Triftazin |
Tryptazine |
Trazine |
Fluoperazine |
Eskazine |
Trifluoroperazine hydrochloride |
Tryptazine dihydrochloride |
Triphthazine dihydrochloride |
Calmazine |
Modalina |
UNII-6P1Y2SNF5V |
Stalazine hydrochloride |
Trifluoroperazine dihydrochloride |
Stelazine dihydrochloride |
Trifluoperazine (dihydrochloride) |
SKF 5019 |
Trifluperazine dihydrochloride |
10-(3-(4-methylpiperazin-1-yl)propyl)-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride |
10-3-(4-Methylpiperazin-1-yl)propyl-2-(trifluoromethyl)-10H-phenothiazine dihydrochloride |
Fluoperazine dihydrochloride |
6P1Y2SNF5V |
Triphthasine |
MFCD00012656 |
10-3-(4-methylpiperazin-1-yl)propyl-2-(trifluoromethyl)phenothiazine;dihydrochloride |
10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, dihydrochloride |
10H-phenothiazine, 10-3-(4-methyl-1-piperazinyl)propyl-2-(trifluoromethyl)-, dihydrochloride |
DSSTox_CID_25085 |
DSSTox_RID_80660 |
DSSTox_GSID_45085 |
10-(3-(4-Methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)phenothiazine dihydrochloride |
10-3-(4-methylpiperazin-1-yl)propyl-2-(trifluoromethyl)phenothiazine dihydrochloride |
CHEBI:9710 |
SR-01000003020 |
NCGC00186653-01 |
Trifluoperazine hydrochloride (VAN) |
CAS-440-17-5 |
EINECS 207-123-0 |
C21H26Cl2F3N3S |
AI3-50137 |
Stelazine (TN) |
10H-Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, hydrochloride (1:2) |
10H-Phenothiazine, 10-3-(4-methyl-1-piperazinyl)propyl-2-(trifluoromethyl)-, hydrochloride (1:2) |
Prestwick_482 |
Trifluoperazine diHCl |
Trifluoperazine hydrochloride USP:JAN |
SCHEMBL341516 |
SPECTRUM1500591 |
Trifluroperazine dihydrochloride |
CHEMBL1257040 |
DTXSID1045085 |
HY-B0532A |
SKF5019 |
HMS1568P08 |
HMS1921G15 |
SKF-5019 |
Tox21_110017 |
Tox21_501232 |
CCG-40290 |
s3201 |
AKOS015895085 |
Tox21_110017_1 |
AC-8081 |
KS-5109 |
LP01232 |
SB19410 |
Phenothiazine, 10-(3-(4-methyl-1-piperazinyl)propyl)-2-(trifluoromethyl)-, dihydrochloride |
NCGC00013226-01 |
NCGC00094474-01 |
NCGC00094474-02 |
NCGC00094474-03 |
NCGC00261917-01 |
Trifluoperazine hydrochloride (JAN/USP) |
Trifluoperazine Dihydrochloride, >/=99% |
EU-0101232 |
FT-0600798 |
SW168675-6 |
T-175 |
T2849 |
C75189 |
D00799 |
T 8516 |
Trifluoperazine dihydrochloride, >=99%, powder |
A826478 |
SR-01000003020-2 |
W-106212 |
Q27108478 |
SR-01000003020-10 |
Trifluoperazine hydrochloride, meets USP testing specifications |
Trifluoperazine Hydrochloride 1.0 mg/ml in Methanol (as free base) |
10-3-(4-methylpiperazin-1-yl)propyl-2-(trifluoromethyl)phenothiazine;dihydrochloride. |
2-Trifluoromethyl-10-3-(1-methyl-4-piperazinyl)propylphenothiazine dihydrochloride |
Trifluoperazine hydrochloride, European Pharmacopoeia (EP) Reference Standard |
Trifluoperazine hydrochloride, United States Pharmacopeia (USP) Reference Standard |
Trifluoperazine dihydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material |
Experimental Data
Trifluoperazine dihydrochloride
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | -8 | NS | N2 | 24134630 | Inactive | ||||||
| Drosophila melanogaster | 200 | umol/L | 50.2 | 51.01 | 1.629 | NS | MALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 20 | umol/L | 54.6 | 55.14 | 0.9757 | NS | FEMALES | 33008901 | Inactive |
Experimental Data Visualization
Trifluoperazine dihydrochloride
Statistics Data
Trifluoperazine dihydrochloride
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -8 | 1 | 1 | |
| Drosophila melanogaster | 1.629 | 1 | 2 |
Statistics Data Visualization
Trifluoperazine dihydrochloride
