Compound Summary
Compound Information
Doxazosin mesylate
Compound Name: | Doxazosin mesylate |
Compound CID: | 62978 |
Synonyms: | Doxazosin mesylate 77883-43-3 Cardura Carduran Cardular More... |
Iupac Name: | [4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid |
InChI: | InChI=1S/C23H25N5O5.CH4O3S/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20;1-5(2,3)4/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26);1H3,(H,2,3,4) |
InChIKey: | VJECBOKJABCYMF-UHFFFAOYSA-N |
Canonical Smiles: | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O |
Isomeric Smiles: | COC1=C(C=C2C(=C1)C(=NC(=N2)N3CCN(CC3)C(=O)C4COC5=CC=CC=C5O4)N)OC.CS(=O)(=O)O |
Molecular Weight: | 547.6 |
Molecular Formula: | C24H29N5O8S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Doxazosin mesylate
Molecular Weight: | 547.6 |
Molecular Formula: | C24H29N5O8S |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 12 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 38 |
Complexity: | 770 |
Synonyms
Doxazosin mesylate
| Doxazosin mesylate | Doxazosin mesylate |
|---|---|
Doxazosin mesylate |
77883-43-3 |
Cardura |
Carduran |
Cardular |
Cardura XL |
Cardenalin |
Dedralen |
Progandol |
Tensiobas |
Doxazosin (mesylate) |
Doxazosin mesilate |
UK 33274 mesylate |
(4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl)(2,3-dihydrobenzob1,4dioxin-2-yl)methanone methanesulfonate |
MLS000028455 |
Doxazomerck |
Diblocin |
C24H29N5O8S |
Doxazosin AZU |
MFCD00216023 |
Prostadilat |
Alfadil |
Cardoral |
Cardoxan |
Doksura |
Doxaben |
Doxolbran |
Kaltensif |
Normathen |
SMR000058441 |
Supressin |
Tonocardin |
Benur |
Cardular Uro |
Diblocin Uro |
Cardular PP |
Diblocin PP |
UK-33,274-27 |
DSSTox_CID_25598 |
DSSTox_RID_80991 |
DSSTox_GSID_45598 |
UK 33274 |
UK-33274 |
Doxazocine |
Duracin |
Dosin |
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-ylcarbonyl)piperazine monomethanesulfonate |
Carduran Neo |
CHEBI:4709 |
4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone;methanesulfonic acid |
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-(1,4-benzodioxan-2-yl)carbonylpiperazine Methanesulfonate |
1-(4-Amino-6,7-dimethoxy-2-quinazolinyl)-4-4-(1,4-benzodioxan-2-yl)carpiperazin-1-yl)-6,7-dimethoxyquinazoline mesylate |
2-{4-(2,3-dihydro-1,4-benzodioxin-2-yl)carbonylpiperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid |
HSDB 7082 |
SR-01000003045 |
Doxazosin mesylate USAN:USP |
UK 33,274-27 |
NCGC00017136-01 |
Cardura (TN) |
CAS-77883-43-3 |
Prestwick_1026 |
doxazosin mesylate salt |
Doxazosin Mesylate,(S) |
Doxazosin methanesulfonate |
Opera_ID_1881 |
Doxazosin mesylate (USP) |
Doxazosin mesilate (JP17) |
SCHEMBL42621 |
2-4-(2,3-dihydro-1,4-benzodioxin-2-ylcarbonyl)piperazin-1-yl-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid |
MLS000120399 |
MLS001148153 |
MLS002222292 |
MLS006011977 |
CHEMBL1200561 |
DTXSID5045598 |
HY-B0098A |
HMS1570L17 |
HMS2093J14 |
HMS2097L17 |
HMS2230L18 |
HMS3261O10 |
HMS3372C03 |
HMS3654J15 |
HMS3714L17 |
HMS3884O09 |
Pharmakon1600-01505976 |
BCP12163 |
Tox21_110796 |
Tox21_500474 |
NSC759284 |
s1324 |
AKOS015895371 |
piperazin-1-yl)(2,3-dihydrobenzob |
Tox21_110796_1 |
AC-6848 |
CCG-213583 |
CS-1830 |
KS-1052 |
LP00474 |
NSC 759284 |
NSC-759284 |
NCGC00016146-02 |
NCGC00018158-09 |
NCGC00093884-01 |
NCGC00261159-01 |
2-4-(2,3-dihydro-1,4-benzodioxine-2-carbonyl)piperazin-1-yl-6,7-dimethoxyquinazolin-4-amine; methanesulfonic acid |
BD164387 |
Piperazine, 1-(4-amino-6,7-dimethoxy-2-quinazolinyl)-4-((2,3-dihydro-1,4-benzodioxin-2-yl)carbonyl)-, monomethanesulfonate |
AB0008587 |
1,4dioxin-2-yl)methanone methanesulfonate |
D4126 |
Doxazosin mesylate, >=97% (HPLC), powder |
EU-0100474 |
FT-0625592 |
SW197099-3 |
EN300-53021 |
UK-33274-27 |
91D858 |
C76492 |
D 9815 |
D00608 |
J10294 |
A839262 |
SR-01000003045-2 |
SR-01000003045-4 |
SR-01000003045-8 |
Q27106443 |
Z1259084903 |
Doxazosin mesilate, European Pharmacopoeia (EP) Reference Standard |
Doxazosin mesylate, United States Pharmacopeia (USP) Reference Standard |
2,3,4a,8a-tetrahydro-1,4-benzodioxin-3-yl-4-(4-amino-6,7-dimethoxy-quinazolin-2-yl)piperazin-1-ylmethanone; methanesulfonate;Doxazosin mesylate |
4-Amino-2-4-(1,4-benzodioxan-2-carbonyl)piperazin-1-yl-6,7-dimethoxyquinazoline methanesulfonate |
Experimental Data
Doxazosin mesylate
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 20 | umol/L | 54.37 | 52.68 | -3.12 | NS | FEMALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 10 | umol/L | 16.59 | 17.75 | 6.962 | NS | N2 | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 33 | umol/L | 15 | S | N2 | 24134630 | Active | ||||||
| Caenorhabditis elegans | 33 | umol/L | 15 | S | N2 | 33683565 | Active | ||||||
| Drosophila melanogaster | 200 | umol/L | 46.39 | 44.67 | -3.7 | NS | MALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 100 | umol/L | 16.8 | 17.29 | 2.962 | NS | N2 | 33008901 | Inactive |
Experimental Data Visualization
Doxazosin mesylate
Statistics Data
Doxazosin mesylate
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 15 | 3 | 4 | |
| Drosophila melanogaster | -3.12 | 1 | 2 |
Statistics Data Visualization
Doxazosin mesylate
