Compound Summary
Compound Information
Diltiazem hydrochloride
Compound Name: | Diltiazem hydrochloride |
Compound CID: | 62920 |
Synonyms: | Diltiazem hydrochloride Diltiazem HCl 33286-22-5 (+)-cis-Diltiazem hydrochloride Dilzem More... |
Iupac Name: | [(2S,3S)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate;hydrochloride |
InChI: | InChI=1S/C22H26N2O4S.ClH/c1-15(25)28-20-21(16-9-11-17(27-4)12-10-16)29-19-8-6-5-7-18(19)24(22(20)26)14-13-23(2)3;/h5-12,20-21H,13-14H2,1-4H3;1H/t20-,21+;/m1./s1 |
InChIKey: | HDRXZJPWHTXQRI-BHDTVMLSSA-N |
Canonical Smiles: | CC(=O)OC1C(SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl |
Isomeric Smiles: | CC(=O)O[C@@H]1[C@@H](SC2=CC=CC=C2N(C1=O)CCN(C)C)C3=CC=C(C=C3)OC.Cl |
Molecular Weight: | 451 |
Molecular Formula: | C22H27ClN2O4S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Diltiazem hydrochloride
Molecular Weight: | 451 |
Molecular Formula: | C22H27ClN2O4S |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 7 |
Heavy Atom Count: | 30 |
Complexity: | 565 |
Synonyms
Diltiazem hydrochloride
| Diltiazem hydrochloride | Diltiazem hydrochloride |
|---|---|
Diltiazem hydrochloride |
Diltiazem HCl |
33286-22-5 |
(+)-cis-Diltiazem hydrochloride |
Dilzem |
Tiazac |
CRD-401 |
Herbesser |
Dilzene |
Lacerol |
Masdil |
Tildiem |
Mono-Tildiem |
Bi-Tildiem |
Cardizem CD |
Cardizem LA |
Dilthiazem hydrochloride |
Cardil |
Dilren |
Adizem |
Diltiazem (hydrochloride) |
(2S,3S)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzob1,4thiazepin-3-yl acetate hydrochloride |
UNII-OLH94387TE |
RG 83606 |
Diltiazem HCl (Tiazac) |
MFCD00069252 |
MLS000028432 |
OLH94387TE |
103532-26-9 |
RG 83606 HCl |
CHEBI:645509 |
Anoheal |
(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride |
(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl acetate;hydrochloride |
Dilzicardin |
Altiazem |
Anginyl |
Angitil |
Angizem |
Britiazim |
Calcicard |
Calnurs |
Cardiazem |
Cirilen |
Citizen |
Clarute |
Corazet |
Deltazen |
Dilacor |
Diladel |
Dilatam |
Dilatame |
Dilcard |
Dilgard |
Dilicardin |
Dilpral |
Dilrene |
Diltahexal |
Diltelan |
Diltiasyn |
Diltikor |
Diltime |
Dinisor |
Dodexen |
Entrydil |
Farmabes |
Gadoserin |
Helsibon |
Incoril |
Kaltiazen |
Levozem |
Longazem |
Lytelsen |
Metazem |
Miocardie |
Oxycardil |
Pazeadin |
Pentilzeno |
Poltiazem |
Presoken |
SMR000058375 |
Surazem |
Tilazem |
Trumsal |
Ziruvate |
Bruzem |
Carzem |
Diatal |
Dilfar |
Dilsal |
Diltam |
Diltan |
Doclis |
Dyalac |
Etizen |
Etyzen |
Herben |
Kardil |
Myonil |
Slozen |
Tiadil |
Tiaves |
Ubicor |
Zildem |
Carex |
Coras |
Dazil |
Dilem |
Dilso |
Hesor |
Tazem |
Apo-diltiazem |
Iski |
Altiazem Retard |
Cardizem Retard |
Diltiazem Merck |
Diltiazem Stada |
Diltiazem Verla |
Diltiazem-Mepha |
33286-22-5 (HCl) |
Cardil Retard |
Dil-Sonaramia |
Diltiazem-Isis |
Dilzem Retard |
Dinisor Retard |
Myonil Retard |
Novo-Diltazem |
Syn-Diltiazem |
Tildiem Retard |
Diltiazem Basics |
Diltiazem-Cophar |
Uni Masdil |
WL Diltiazem |
Altiazem RR |
Cardizem SR |
Diltiazem AWD |
Diltiazem GNR |
Diltiazem MSD |
Diltiazem-GRY |
Cirilen AP |
Diltiazem Henning |
Diltiazem UPSA |
Tildiem CR |
Tildiem LA |
Adizem-CD |
Cartia XT |
Diltan SR |
Diltiazem Eu Rho |
Dilzem RR |
Taztia XT |
Viazem SR |
Viazem XL |
Herbesser 60 |
C22H26N2O4S.HCl |
(2S-cis)-3-Acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride |
(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl acetate;hydron;chloride |
38411-61-9 |
Herbesser 90 SR |
Tilazem 90 |
Diltiazem chloridrate |
Dilatam 120 |
Tilazem AS 60 |
Tilazem AS 90 |
Dilzereal 90 Retard |
Herbesser 180 SR |
Dolizem |
Iski-90 SR |
Diltia XT |
Dilt-XR |
Dodexen A.P. |
Presokin A. P. |
MK-793 |
CRD 401 |
Tiazac extended release |
Diltiazem, Hydrochloride |
SR-01000003042 |
RG-83606 |
EINECS 251-443-3 |
Dilacor XR Extended Release Capsules |
Milptin |
Carzen |
Slozem |
CRD401 |
Dilthiazem HCl |
DOV diltiazem |
Uni-Masdil |
Cardizem XL |
Tiazac XC |
Cardizem (TN) |
Prestwick_176 |
acetate hydrochloride |
EINECS 253-918-0 |
Dilacor XR (TN) |
Cartia XT (TN) |
Opera_ID_79 |
Diltiazem hydrochloride USAN:USP:JAN |
Dilt-CD (TN) |
(+)-5-(2-(dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate ester monohydrochloride |
2-(2S,3S)-3-(acetyloxy)-2-(4-methoxyphenyl)-4-oxo-3,4-dihydro-1,5-benzothiazepin-5(2H)-yl-N,N-dimethylethanaminium chloride |
CHEMBL1697 |
Diltiazem Hydrochloride,(S) |
SCHEMBL15457 |
(+)-5-(2-(Dimethylamino)ethyl)-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester) monohydrochloride |
MLS001148257 |
MLS002222179 |
DTXSID8040147 |
AMY8835 |
SLV-324 |
VEN-307 |
HMS1568K10 |
(2S-trans)-Diltiazem Hydrochloride |
ACT02682 |
BCP13814 |
Tox21_500327 |
BNP-32762 |
Diltiazem hydrochloride (JP17/USP) |
s1865 |
3,3,3-phosphinylidynetrispropionamide |
AKOS015961992 |
CCG-220134 |
CCG-221631 |
KS-5089 |
LP00327 |
NC00558 |
NSC 759576 |
tetrahydrobenzob1,4thiazepin-3-yl |
NCGC00093768-01 |
NCGC00261012-01 |
(2S,3S)-(+)-3-Acetoxy-2,3-dihydro-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride |
1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-, monohydrochloride, cis-(+)- |
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (+)-cis- |
AC-15189 |
AC-32469 |
AS-13703 |
BD166408 |
cis-(1)-3-Acetoxy-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride |
HY-14656 |
(+)-cis-Diltiazem Hydrochloride, >/=98% |
(2S,3S)-5-(2-(dimethylamino)ethyl)-2 |
D3662 |
EU-0100327 |
ST50320016 |
SW196487-3 |
BIM-0050315.0001 |
D 2521 |
D00616 |
Diltiazem, Hydrochloride - CAS 33286-22-5 |
F20448 |
J10138 |
M01693 |
(+)-cis-Diltiazem hydrochloride, >=99% (HPLC) |
286D225 |
SR-01000075327 |
J-019130 |
SR-01000003042-2 |
SR-01000003042-4 |
SR-01000075327-1 |
Q27105183 |
Diltiazem Hydrochloride 1.0 mg/ml in Acetonitrile (as free base) |
Diltiazem hydrochloride, European Pharmacopoeia (EP) Reference Standard |
Diltiazem hydrochloride, United States Pharmacopeia (USP) Reference Standard |
Diltiazem for system suitability, European Pharmacopoeia (EP) Reference Standard |
(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride |
(2S,3S)-5-(2-(DIMETHYLAMINO)ETHYL)-2-(4-METHOXYPHENYL)-4-OXO-2,3,4,5-TETRAHYDROBENZOB1,4THIAZEPIN-3-YL ACETATE HCL |
(2S,3S)-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-4-oxo-2H,3H-benzob1,4 -thiazaperhydroepin-3-yl acetate, chloride |
(2S-cis)-3-(Acetyloxy)-5-2-(dimethylamino)ethyl-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride |
Acetic acid (2S,3S)-5-(2-dimethylamino-ethyl)-2-(4-methoxy-phenyl)-4-oxo-2,3,4,5-tetrahydro-benzob1,4thiazepin-3-yl ester; hydrochloride |
cis-(+)-3-acetoxy-2,3-dihydro-5-2-(dimethylamino)ethyl-2-(4-methoxyphenyl)-1,5-benzothiazepine-4(5H)-one hydrochloride |
Diltiazem hydrochloride solution, 1.0 mg/mL in acetonitrile (as free base), ampule of 1 mL, certified reference material |
Experimental Data
Diltiazem hydrochloride
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | -2 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
Diltiazem hydrochloride
Statistics Data
Diltiazem hydrochloride
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -2 | 1 | 1 |
Statistics Data Visualization
Diltiazem hydrochloride
