Compound Summary
Compound Information
mifepristone
Compound Name: | mifepristone |
Compound CID: | 55245 |
Synonyms: | mifepristone 84371-65-3 Mifegyne Mifeprex RU-486 More... |
Iupac Name: | (8S,11R,13S,14S,17S)-11-[4-(dimethylamino)phenyl]-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one |
InChI: | InChI=1S/C29H35NO2/c1-5-15-29(32)16-14-26-24-12-8-20-17-22(31)11-13-23(20)27(24)25(18-28(26,29)2)19-6-9-21(10-7-19)30(3)4/h6-7,9-10,17,24-26,32H,8,11-14,16,18H2,1-4H3/t24-,25+,26-,28-,29-/m0/s1 |
InChIKey: | VKHAHZOOUSRJNA-GCNJZUOMSA-N |
Canonical Smiles: | CC#CC1(CCC2C1(CC(C3=C4CCC(=O)C=C4CCC23)C5=CC=C(C=C5)N(C)C)C)O |
Isomeric Smiles: | CC#C[C@@]1(CC[C@@H]2[C@@]1(C[C@@H](C3=C4CCC(=O)C=C4CC[C@@H]23)C5=CC=C(C=C5)N(C)C)C)O |
Molecular Weight: | 429.6 |
Molecular Formula: | C29H35NO2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
mifepristone
Molecular Weight: | 429.6 |
Molecular Formula: | C29H35NO2 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 3 |
Heavy Atom Count: | 32 |
Complexity: | 921 |
Synonyms
mifepristone
| mifepristone | mifepristone |
|---|---|
mifepristone |
84371-65-3 |
Mifegyne |
Mifeprex |
RU-486 |
Corlux |
Korlym |
RU486 |
RU 486 |
RU 38486 |
Mifepriston |
RU-38486 |
UNII-320T6RNW1F |
MLS000069785 |
320T6RNW1F |
VGX-410C |
CHEBI:50692 |
VGX-410 |
NCGC00025179-05 |
SMR000058481 |
Mifepristonum Latin |
Mifepristona Spanish |
DSSTox_CID_3322 |
C-1073 |
DSSTox_RID_76976 |
DSSTox_GSID_23322 |
(11beta,17beta)-11-4-(Dimethylamino)phenyl-17-hydroxy-17-(1-propyn-1-yl)estra-4,9-dien-3-one |
(8S,11R,13S,14S,17S)-11-(4-(dimethylamino)phenyl)-17-hydroxy-13-methyl-17-(prop-1-yn-1-yl)-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-3H-cyclopentaaphenanthren-3-one |
(8S,11R,13S,14S,17S)-11-(4-dimethylaminophenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaaphenanthren-3-one |
(8S,11R,13S,14S,17S)-11-4-(dimethylamino)phenyl-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaaphenanthren-3-one |
11-(4-DIMETHYLAMINO-PHENYL)-17-HYDROXY-13-METHYL-17-PROP-1-YNYL-1,2,6,7,8,11,12,13,14,15,16,17-DODEC AHYDRO-CYCLOPENTAAPHENANTHREN-3-ONE |
Mifepristona |
Mifepristonum |
(11beta,17beta)-11-4-(dimethylamino)phenyl-17-hydroxy-17-prop-1-yn-1-ylestra-4,9-dien-3-one |
RU486 (tetramethyl-rhodamine conjugated) |
Mifepristone USAN:INN:BAN |
HSDB 6841 |
SR-01000076011 |
R 38486 |
BRN 5779404 |
Pictovir |
RU 486-6 |
CCRIS 9332 |
1nhz |
11beta-(p-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
Mifeprex (TN) |
Pictovir (TM) |
Prestwick_570 |
CAS-84371-65-3 |
Korlym (TN) |
2w8y |
Mifepristone (Mifeprex) |
Opera_ID_562 |
Mifepristone, >=98% |
Prestwick0_000299 |
Prestwick1_000299 |
Prestwick2_000299 |
Prestwick3_000299 |
Spectrum5_002045 |
11beta-(4-(Dimethylamino)phenyl)-17beta-hydroxy-17-(1-propynyl)estra-4,9-dien-3-on |
17-beta-Hydroxy-11-beta-(4-dimethylaminophenyl-1)-17-alpha-(prop-1-ynyl)oestra-4,9-dien-3-one |
BIDD:PXR0123 |
Lopac0_000801 |
SCHEMBL16087 |
BSPBio_000238 |
11beta-(4-(Dimethylamino)phenyl)-17-hydroxy-21-methyl-19-nor-17alpha-pregna-4,9-dien-20-m-3-on |
11beta-(4-(N,N-Dimethylamino)phenyl)-17alpha-(prop-1-ynyl)-delta4,9-estradiene-17beta-ol-3-one |
MLS001074115 |
MLS001424271 |
(non-labelled)Mifepristone-d3 |
ARONIS27015 |
SPBio_002457 |
RU-486; MIFEPRISTONE |
BPBio1_000262 |
CHEMBL438575 |
GTPL2805 |
Mifepristone (JAN/USAN/INN) |
CHEMBL1276308 |
DTXSID5023322 |
BDBM18627 |
AOB6893 |
HMS1568L20 |
HMS2052L05 |
HMS2090L22 |
HMS2095L20 |
HMS2230P21 |
HMS3262B03 |
HMS3412D17 |
HMS3649J08 |
HMS3676D17 |
HMS3712L20 |
HMS3884D12 |
ACT02598 |
BCP02145 |
ZINC3831128 |
Tox21_110952 |
Tox21_301841 |
Tox21_500801 |
BDBM50072024 |
HSCI1_000369 |
MFCD00867226 |
s2606 |
VX-410 |
AKOS015895416 |
Tox21_110952_1 |
CCG-101164 |
CI-1073 |
CS-1435 |
DB00834 |
LP00801 |
NC00414 |
NSC 759862 |
SDCCGSBI-0050778.P002 |
Mifepristone 1.0 mg/ml in Acetonitrile |
NCGC00025179-06 |
NCGC00025179-07 |
NCGC00025179-08 |
NCGC00025179-09 |
NCGC00025179-12 |
NCGC00025179-13 |
NCGC00025179-23 |
NCGC00179632-01 |
NCGC00255152-01 |
NCGC00261486-01 |
(11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one |
(11beta,17beta)-11-(4-(Dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
AS-13938 |
CPD000058481 |
Estra-4,9-dien-3-one, 11-(4-(dimethylamino)phenyl)-17-hydroxy-17-(1-propynyl)-, (11-beta,17-beta)- |
HY-13683 |
RU486;C-1073 |
EU-0100801 |
C07652 |
D00585 |
M 8046 |
29523-EP2272827A1 |
29523-EP2275420A1 |
29523-EP2295055A2 |
29523-EP2295416A2 |
29523-EP2298748A2 |
29523-EP2298764A1 |
29523-EP2298765A1 |
29523-EP2305642A2 |
29523-EP2308880A1 |
29523-EP2311453A1 |
29523-EP2311808A1 |
29523-EP2311829A1 |
29523-EP2311842A2 |
75603-EP2269977A2 |
75603-EP2308880A1 |
371M653 |
A840767 |
Q411240 |
SR-01000721888 |
Q-201405 |
SR-01000076011-1 |
SR-01000076011-3 |
SR-01000076011-5 |
SR-01000076011-9 |
SR-01000721888-4 |
BRD-K37270826-001-04-5 |
BRD-K37270826-001-31-8 |
Mifepristone, United States Pharmacopeia (USP) Reference Standard |
(11?,17?)-11-4-(Dimethylamino)phenyl-17-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one |
11.beta.-4-(Dimethylamino)phenyl-17.beta.-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one |
11beta-(4-Dimethyl-amino)-phenyl-17beta-hydroxy-17-(1-propynyl)-estra-4,9-dien-3-one |
11ss-p-(Dimethylamino)fenyl-17ss-hydroxy- 17-(1-propynyl)estra-4,9-dien-3-on |
(10S,11S,14S,15S,17R)-17-4-(dimethylamino)phenyl-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo8.7.0.0;{2,7}.0;{11,15}heptadeca-1,6-dien-5-one |
(10S,11S,14S,15S,17R)-17-4-(dimethylamino)phenyl-14-hydroxy-15-methyl-14-(prop-1-yn-1-yl)tetracyclo8.7.0.0^{2,7}.0^{11,15}heptadeca-1,6-dien-5-one |
(11R,13S,14S,17S)-11-(4-Dimethylamino-phenyl)-17-hydroxy-13-methyl-17-prop-1-ynyl-1,2,6,7,8,11,12,13,14,15,16,17-dodecahydro-cyclopentaaphenanthren-3-one |
(8S,11R,13S,14S,17S)-11-4-(dimethylamino)phenyl-13-methyl-17-oxidanyl-17-prop-1-ynyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopentaaphenanthren-3-one |
122742-25-0 |
83203-42-3 |
Estra-4,9-dien-3-one, 11-4-(dimethylamino)phenyl-17-hydroxy-17-(1-propynyl)-, (11b,17b)- |
Experimental Data
mifepristone
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | -5 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
mifepristone
Statistics Data
mifepristone
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -5 | 1 | 1 |
Statistics Data Visualization
mifepristone
