Compound Summary
Compound Information
licochalcone a
Compound Name: | licochalcone a |
Compound CID: | 5318998 |
Synonyms: | licochalcone a 58749-22-7 Licochalcone-A UNII-JTV5467968 CHEMBL139702 More... |
Iupac Name: | (E)-3-[4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl]-1-(4-hydroxyphenyl)prop-2-en-1-one |
InChI: | InChI=1S/C21H22O4/c1-5-21(2,3)17-12-15(20(25-4)13-19(17)24)8-11-18(23)14-6-9-16(22)10-7-14/h5-13,22,24H,1H2,2-4H3/b11-8+ |
InChIKey: | KAZSKMJFUPEHHW-DHZHZOJOSA-N |
Canonical Smiles: | CC(C)(C=C)C1=C(C=C(C(=C1)C=CC(=O)C2=CC=C(C=C2)O)OC)O |
Isomeric Smiles: | CC(C)(C=C)C1=C(C=C(C(=C1)/C=C/C(=O)C2=CC=C(C=C2)O)OC)O |
Molecular Weight: | 338.4 |
Molecular Formula: | C21H22O4 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
licochalcone a
Molecular Weight: | 338.4 |
Molecular Formula: | C21H22O4 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 25 |
Complexity: | 488 |
Synonyms
licochalcone a
| licochalcone a | licochalcone a |
|---|---|
licochalcone a |
58749-22-7 |
Licochalcone-A |
UNII-JTV5467968 |
CHEMBL139702 |
JTV5467968 |
(E)-3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one |
(E)-3-4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl-1-(4-hydroxyphenyl)prop-2-en-1-one |
Licochalcone-A, Synthetic |
3-Dimethylallyl-4,4-dihydroxy-6-methoxychalcone |
(2E)-3-4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl-1-(4-hydroxyphenyl)prop-2-en-1-one |
LICOAGROCHACONE A |
LicochalconeA |
Licohalconel A |
(E)-3-5-(1,1-Dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl-1-(4-hydroxyphenyl)-2-propen-1-one |
SCHEMBL114042 |
DTXSID10904181 |
CHEBI:125689 |
CHEBI:174541 |
BCP08941 |
EBD46703 |
EX-A1193 |
HY-N0372 |
ZINC3873123 |
BDBM50068270 |
HSCI1_000078 |
LMPK12120424 |
MFCD01417903 |
s7828 |
AKOS026673964 |
CCG-208030 |
CS-5603 |
Licochalcone A, >=96.0% (HPLC) |
(E)-3-5-(1,1-dimethylallyl)-4-hydroxy-2-methoxy-phenyl-1-(4-hydroxyphenyl)prop-2-en-1-one |
2-Propen-1-one, 3-(5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)-, (E)- |
AC-34241 |
AS-74730 |
AB0021119 |
V2343 |
749L227 |
A902621 |
Q-100677 |
Q1644097 |
BRD-K99667445-001-01-4 |
Chalcone base + 2O, 1MeO, 1Prenyl or Licochalcone A (Not validated) |
(E)-3-5-(1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl-1-(4-hydroxy-phenyl)-propenone |
3-5-((E)-1,1-Dimethyl-allyl)-4-hydroxy-2-methoxy-phenyl-1-(4-hydroxy-phenyl)-propenone |
(2E)-3-5-(1,1-dimethyl-2-propen-1-yl)-4-hydroxy-2-methoxyphenyl-1-(4-hydroxyphenyl)-2-propen-1-one |
2-Propen-1-one, 3-5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl-1-(4-hydroxyphenyl)- (E)- |
2-Propen-1-one,3-5-(1,1-dimethyl-2-propenyl)-4-hydroxy-2-methoxyphenyl-1-(4-hydroxyphenyl)-, (2E)- |
3-(4-hydroxy-2-methoxy-5-(2-methylbut-3-en-2-yl)phenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one |
Experimental Data
licochalcone a
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 100 | umol/L | 17.08 | 13.5 | -20.92 | NS | N2 | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 10 | umol/L | 15.38 | 15.35 | -0.1801 | NS | N2 | 33008901 | Inactive | ||||
| Drosophila melanogaster | 200 | umol/L | 44.8 | 48.58 | 8.429 | NS | MALES | 33008901 | Inactive | ||||
| Drosophila melanogaster | 20 | umol/L | 45.44 | 46.3 | 1.895 | NS | FEMALES | 33008901 | Inactive |
Experimental Data Visualization
licochalcone a
Statistics Data
licochalcone a
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -0.1801 | 1 | 2 | |
| Drosophila melanogaster | 8.429 | 1 | 2 |
Statistics Data Visualization
licochalcone a
