Compound Summary
Compound Information
Flunarizine dihydrochloride
Compound Name: | Flunarizine dihydrochloride |
Compound CID: | 5282407 |
Synonyms: | Flunarizine dihydrochloride flunarizine hydrochloride 30484-77-6 Flunarizine 2HCl Flunarizine HCl More... |
Iupac Name: | 1-[bis(4-fluorophenyl)methyl]-4-[(E)-3-phenylprop-2-enyl]piperazine;dihydrochloride |
InChI: | InChI=1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;; |
InChIKey: | RXKMOPXNWTYEHI-RDRKJGRWSA-N |
Canonical Smiles: | C1CN(CCN1CC=CC2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl |
Isomeric Smiles: | C1CN(CCN1C/C=C/C2=CC=CC=C2)C(C3=CC=C(C=C3)F)C4=CC=C(C=C4)F.Cl.Cl |
Molecular Weight: | 477.4 |
Molecular Formula: | C26H28Cl2F2N2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Flunarizine dihydrochloride
Molecular Weight: | 477.4 |
Molecular Formula: | C26H28Cl2F2N2 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 4 |
Rotatable Bond Count: | 6 |
Heavy Atom Count: | 32 |
Complexity: | 487 |
Synonyms
Flunarizine dihydrochloride
| Flunarizine dihydrochloride | Flunarizine dihydrochloride |
|---|---|
Flunarizine dihydrochloride |
flunarizine hydrochloride |
30484-77-6 |
Flunarizine 2HCl |
Flunarizine HCl |
Flunarizine diHCl |
27064-95-5 |
Flunarizine (dihydrochloride) |
Sibelium |
KW-3149 |
UNII-C11102TO53 |
1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride |
MFCD00058198 |
1-bis(4-fluorophenyl)methyl-4-(E)-3-phenylprop-2-enylpiperazine;dihydrochloride |
C11102TO53 |
1-Bis(4-fluorophenyl)methyl-4-(3-phenyl-2-propenyl)piperazine dihydrochloride |
1-BIS(4-FLUOROPHENYL)METHYL-4-CINNAMYLPIPERAZINE DIHYDROCHLORIDE |
(E)-1-(Bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)piperazine dihydrochloride |
R 14,950 |
Flugeral |
SR-01000000006 |
EINECS 250-216-6 |
Flunarizine hydrochloride USAN:JAN |
C26H28Cl2F2N2 |
(E)-1-Bis(4-fluorophenyl)methyl-4-(3-phenyl-2-propenyl)piperazine dihydrochloride |
R 14950 |
Prestwick_222 |
EINECS 248-203-5 |
Flunarizine dihydroch |
(E)-1-(Bis-(p-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride |
Flunarizine hydrochloride,(S) |
SPECTRUM1500993 |
CHEMBL552659 |
SCHEMBL1009444 |
SCHEMBL1321708 |
CHEBI:31621 |
HY-B0358A |
DTXSID80184554 |
HMS1568P06 |
HMS1921O12 |
HMS3411C08 |
HMS3675C08 |
BCP02932 |
3-(3-QUINOLINYL)ACRYLICACID |
Tox21_500527 |
CCG-39000 |
s2030 |
Flunarizine hydrochloride (JAN/USAN) |
(E)-1-(Bis(4-fluorophenyl)methyl)-4-cinnamylpiperazine dihydrochloride |
AKOS015895373 |
Piperazine, 1-(bis(p-fluorophenyl)methyl)-4-cinnamyl-, dihydrochloride, (E)- |
AC-2152 |
BCP9000695 |
KS-5125 |
LP00527 |
NSC 757807 |
1-bis(4-fluorophenyl)methyl-4-(E)-3-phenylprop-2-enylpiperazine dihydrochloride |
Piperazine, 1-(bis(4-fluorophenyl)methyl)-4-(3-phenyl-2-propenyl)-, dihydrochloride, (E)- |
NCGC00093920-01 |
NCGC00093920-02 |
NCGC00093920-03 |
NCGC00261212-01 |
BF166238 |
LS-15141 |
BCP0726000286 |
AB0012900 |
Flunarizine dihydrochloride, >=98% (TLC) |
EU-0100527 |
ST51015006 |
SW196530-3 |
A51066 |
D01303 |
F 8257 |
R14950 |
484F776 |
A820398 |
Q-100983 |
SR-01000000006-2 |
SR-01000000006-4 |
SR-01000000006-9 |
Q27275038 |
Flunarizine Dihydrochloride 1.0 mg/ml in Methanol (as free base) |
Flunarizine dihydrochloride, European Pharmacopoeia (EP) Reference Standard |
1-bis(4-fluorophenyl)methyl-4-(3-phenyl-2-propenyl)-piperazine dihydrochloride |
1-BIS(4-FLUOROPHENYL)METHYL-4-(E)-3-PHENYLPROP-2-ENYLPIPERAZINE 2HCL |
4-((2E)-3-phenylprop-2-enyl)-1-bis(4-fluorophenyl)methylpiperazine, chloride , chloride |
Flunarizine dihydrochloride for system suitability, European Pharmacopoeia (EP) Reference Standard |
Experimental Data
Flunarizine dihydrochloride
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | -27 | NS | N2 | 24134630 | Inactive | ||||||
| Drosophila melanogaster | 20 | umol/L | 46.24 | 49.91 | 7.937 | S | FEMALES | 33008901 | Active | ||||
| Drosophila melanogaster | 200 | umol/L | 46.64 | 45.16 | -3.164 | NS | MALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 10 | umol/L | 16.89 | 17 | 0.6274 | NS | N2 | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 100 | umol/L | 15.34 | 16.35 | 6.565 | NS | N2 | 33008901 | Inactive |
Experimental Data Visualization
Flunarizine dihydrochloride
Statistics Data
Flunarizine dihydrochloride
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 6.565 | 2 | 3 | |
| Drosophila melanogaster | 7.937 | 1 | 2 |
Statistics Data Visualization
Flunarizine dihydrochloride
