Compound Summary
Compound Information
2-ketoglutaric acid
Compound Name: | 2-ketoglutaric acid |
Compound CID: | 51 |
Synonyms: | 2-ketoglutaric acid 2-Oxopentanedioic acid 328-50-7 alpha-ketoglutaric acid 2-oxoglutaric acid More... |
Iupac Name: | 2-oxopentanedioic acid |
InChI: | InChI=1S/C5H6O5/c6-3(5(9)10)1-2-4(7)8/h1-2H2,(H,7,8)(H,9,10) |
InChIKey: | KPGXRSRHYNQIFN-UHFFFAOYSA-N |
Canonical Smiles: | C(CC(=O)O)C(=O)C(=O)O |
Isomeric Smiles: | C(CC(=O)O)C(=O)C(=O)O |
Molecular Weight: | 146.1 |
Molecular Formula: | C5H6O5 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
2-ketoglutaric acid
Molecular Weight: | 146.1 |
Molecular Formula: | C5H6O5 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 4 |
Heavy Atom Count: | 10 |
Complexity: | 171 |
Synonyms
2-ketoglutaric acid
| 2-ketoglutaric acid | 2-ketoglutaric acid |
|---|---|
2-ketoglutaric acid |
2-Oxopentanedioic acid |
328-50-7 |
alpha-ketoglutaric acid |
2-oxoglutaric acid |
2-oxoglutarate |
Oxoglutaric acid |
alpha-ketoglutarate |
Oxoglutarate |
Alphaketoglutaric acid |
alpha-Oxoglutaric acid |
2-Oxo-1,5-pentanedioic acid |
Pentanedioic acid, 2-oxo- |
alpha Ketoglutarate |
oxogluric acid |
Glutaric acid, alpha keto |
2-ketoglutarate |
Pentanedioic acid, oxo- |
Oxoglurate |
2-Oxo-Glutaric Acid |
Bis(L-arginin)-2-oxoglutarat |
Glutaric acid, 2-oxo- |
a-ketoglutaric acid |
alpha ketoglutaric acid |
AI3-26938 |
MFCD00004165 |
NSC 17391 |
alpha-Ketoglutaric acid alpha |
UNII-8ID597Z82X |
Glutaric acid, 2-oxo- (8CI) |
2-oxo-pentanedioic acid |
alpha-keto-Glutaric acid |
NSC17391 |
.alpha.-Oxoglutaric acid |
.alpha.-Ketoglutaric acid |
CHEMBL1686 |
CHEBI:30915 |
17091-15-5 |
8ID597Z82X |
NSC-17391 |
378-50-7 |
2-oxopentanedioate |
2-oxopentanedionate |
DSSTox_CID_13179 |
DSSTox_RID_79054 |
DSSTox_GSID_33179 |
Pentanedioic acid, 2-oxo-, sodium salt |
Pentanedioic acid, 2-oxo-, sodium salt (1:?) |
ketoglutaric acid |
Ketoglutaric Acids |
CAS-328-50-7 |
Oxoglurate INN |
22202-68-2 |
997-43-3 |
AKG |
EINECS 206-330-3 |
alpha-Ketoglutaricum acidum |
C5H6O5 |
3ouj |
4nro |
4oct |
4qkd |
4usi |
keto glutaric acid |
2-oxoglutaric-acid |
2-oxo-pentanedioicaci |
alpha-oxo-glutaric acid |
alpha-Oxopentanedioic acid |
ACMC-1BMR3 |
2-Oxo-1,5-pentanedioate |
bmse000064 |
bmse000801 |
bmse000937 |
SCHEMBL7400 |
NCIStruc1_001710 |
NCIStruc2_000215 |
Glutaric acid, .alpha.-keto- |
GTPL3636 |
DTXSID5033179 |
EBD44199 |
NCI17391 |
Pentanedioic acid, 2-oxo- (9CI) |
ZINC1532519 |
Tox21_110016 |
Tox21_200918 |
BBL010614 |
BDBM50303766 |
CCG-37641 |
NCGC00013225 |
s6237 |
SBB056419 |
STK002174 |
AKOS000120908 |
CS-W014352 |
DB02926 |
DB03806 |
DB08845 |
HY-W013636 |
MCULE-5148157449 |
NCGC00013225-01 |
NCGC00013225-02 |
NCGC00013225-03 |
NCGC00013225-04 |
NCGC00013225-05 |
NCGC00013225-06 |
NCGC00090946-01 |
NCGC00090946-02 |
NCGC00258472-01 |
34410-46-3 |
alpha-Ketoglutaric acid, >=99.0% (T) |
AS-12579 |
NCI60_001411 |
SY004310 |
DB-048280 |
AM20090486 |
FT-0612734 |
FT-0670633 |
K0005 |
ST45138045 |
C00026 |
D70548 |
K-2400 |
11044-EP2269610A2 |
11044-EP2277848A1 |
11044-EP2289510A1 |
11044-EP2316457A1 |
11044-EP2316458A1 |
11044-EP2316825A1 |
11044-EP2316826A1 |
11044-EP2316827A1 |
11044-EP2316828A1 |
AB00640269-03 |
A855282 |
Q306140 |
alpha-Ketoglutaric acid, >=98.5% (NaOH, titration) |
Z57127547 |
F2191-0182 |
15118487-024F-412C-9995-24E8E6CA72EF |
alpha-Ketoglutaric acid, BioReagent, suitable for cell culture, suitable for insect cell culture |
Experimental Data
2-ketoglutaric acid
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 8 | mM | 14 | 20.7 | 0.48 | S | N2 | 26190651 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 15.7 | 21.5 | 0.37 | S | N2 | 26190651 | Active | ||||
| Drosophila melanogaster | 20 | umol/L | 52.83 | 56.92 | 7.74 | S | FEMALES | 33008901 | Active | ||||
| Drosophila melanogaster | 200 | umol/L | 47.16 | 48.65 | 3.16 | NS | MALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 8 | mM | 18 | 23 | 0.28 | S | N2 | 31820364 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 14 | 20.7 | 47.9 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 21.5 | 14.6 | 14.6 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 16.8 | 22.4 | 32 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 15.7 | 21.6 | 32.7 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 18.4 | 24.6 | 33.4 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 15.6 | 26.3 | 68.8 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 13.6 | 20.7 | 51.8 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 17.5 | 25.4 | 45.6 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 16.1 | 19.1 | 19.3 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 16.7 | 23.4 | 39.7 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 15.8 | 22.2 | 40.5 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 16.3 | 26.1 | 60.2 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 18.9 | 25.8 | 36.3 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 14.7 | 21.6 | 46.9 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 13.2 | 22.3 | 69.8 | S | N2 | 24828042 | Active | ||||
| Caenorhabditis elegans | 8 | mM | 15.6 | 26.3 | 23.3 | S | N2 | 24828042 | Active |
Experimental Data Visualization
2-ketoglutaric acid
Statistics Data
2-ketoglutaric acid
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 69.8 | 3 | 19 | |
| Drosophila melanogaster | 7.74 | 1 | 2 |
Statistics Data Visualization
2-ketoglutaric acid
