Compound Summary
Compound Information
ritanserin
Compound Name: | ritanserin |
Compound CID: | 5074 |
Synonyms: | ritanserin 87051-43-2 Tiserton Ritanserine Ritanserina More... |
Iupac Name: | 6-[2-[4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl]ethyl]-7-methyl-[1,3]thiazolo[3,2-a]pyrimidin-5-one |
InChI: | InChI=1S/C27H25F2N3OS/c1-18-24(26(33)32-16-17-34-27(32)30-18)12-15-31-13-10-21(11-14-31)25(19-2-6-22(28)7-3-19)20-4-8-23(29)9-5-20/h2-9,16-17H,10-15H2,1H3 |
InChIKey: | JUQLTPCYUFPYKE-UHFFFAOYSA-N |
Canonical Smiles: | CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3 |
Isomeric Smiles: | CC1=C(C(=O)N2C=CSC2=N1)CCN3CCC(=C(C4=CC=C(C=C4)F)C5=CC=C(C=C5)F)CC3 |
Molecular Weight: | 477.6 |
Molecular Formula: | C27H25F2N3OS |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
ritanserin
Molecular Weight: | 477.6 |
Molecular Formula: | C27H25F2N3OS |
Hydrogen Bond Donor Count: | 0 |
Hydrogen Bond Acceptor Count: | 6 |
Rotatable Bond Count: | 5 |
Heavy Atom Count: | 34 |
Complexity: | 877 |
Synonyms
ritanserin
| ritanserin | ritanserin |
|---|---|
ritanserin |
87051-43-2 |
Tiserton |
Ritanserine |
Ritanserina |
Ritanserinum |
R-55667 |
R 55,667 |
UNII-145TFV465S |
6-(2-(4-(bis(4-fluorophenyl)methylene)piperidin-1-yl)ethyl)-7-methyl-5H-thiazolo3,2-apyrimidin-5-one |
6-2-4-bis(4-fluorophenyl)methylidenepiperidin-1-ylethyl-7-methyl-1,3thiazolo3,2-apyrimidin-5-one |
MFCD00069341 |
MLS000069360 |
CHEMBL267777 |
6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo3,2-apyrimidin-5-one |
6-(2-(4-(Bis(p-fluorophenyl)methylene)-piperidino)ethyl)-7-methyl-5H-thiazolo-(3,2-a)pyrimidin-5-one |
6-(2-{4-bis(4-fluorophenyl)methylidenepiperidin-1-yl}ethyl)-7-methyl-5H-1,3thiazolo3,2-apyrimidin-5-one |
CHEBI:64195 |
145TFV465S |
NCGC00015877-06 |
SMR000058511 |
DSSTox_CID_22594 |
DSSTox_RID_80055 |
DSSTox_GSID_42594 |
6-2-4-(bis(4-Fluorophenyl)methylene-1-piperidinylethyl-7-methyl-5H-thiazolo3,2-apyrimidin-5-one |
6-2-4-bis(4-fluorophenyl)methylidenepiperidin-1-ylethyl-7-methyl-1,3thiazolo2,3-bpyrimidin-5-one |
Ritanserine French |
Ritanserinum Latin |
Ritanserina Spanish |
C27H25F2N3OS |
5H-Thiazolo(3,2-a)pyrimidin-5-one, 6-(2-(4-bis(4-fluorophenyl)methylene)-1-piperidinyl)ethyl)-7-methyl- |
6-2-4-bis(4-fluorophenyl)methylene-1-piperidinylethyl-7-methyl-5H-thiazolo3,2-apyrimidin-5-one |
CAS-87051-43-2 |
SR-01000000024 |
Ritanserin USAN:INN:BAN |
Ritanserin, powder |
Tiserton (TN) |
5H-Thiazolo3,2-apyrimidin-5-one, 6-2-4-bis(4-fluorophenyl)methylene-1-piperidinylethyl-7-methyl- |
6-2-4-Bis(p-fluorophenyl)methylene-piperidinoethyl-7-methyl-5H-thiazolo-3,2-apyrimidin-5-one |
Spectrum_001830 |
Lopac-R-103 |
Opera_ID_1609 |
Ritanserin (USAN/INN) |
Spectrum2_001560 |
Spectrum3_001023 |
Spectrum5_001504 |
GTPL97 |
cid_5074 |
Lopac0_001083 |
REGID_for_CID_5074 |
SCHEMBL49227 |
BSPBio_002805 |
KBioSS_002335 |
MLS001148629 |
DivK1c_000192 |
SPBio_001440 |
DTXSID9042594 |
HMS500J14 |
KBio1_000192 |
KBio2_002332 |
KBio2_004900 |
KBio2_007468 |
KBio3_002025 |
NINDS_000192 |
HMS2093E19 |
HMS2233M22 |
HMS3263I08 |
HMS3268O04 |
HMS3373O19 |
HMS3412N14 |
HMS3676N14 |
Pharmakon1600-01503421 |
ZINC538314 |
BCP13728 |
Tox21_110251 |
Tox21_501083 |
3726AC |
BDBM50001775 |
CCG-39338 |
NSC758470 |
NSC805597 |
AKOS015909799 |
Tox21_110251_1 |
DB12693 |
LP01083 |
NSC 758470 |
NSC-758470 |
NSC-805597 |
SDCCGSBI-0051053.P004 |
6-2-4-Bis(4-fluorophenyl)Methylidenepiperidin-1-ylethyl-7-Methyl-1,3thia |
IDI1_000192 |
NCGC00015877-01 |
NCGC00015877-02 |
NCGC00015877-03 |
NCGC00015877-04 |
NCGC00015877-05 |
NCGC00015877-07 |
NCGC00015877-08 |
NCGC00015877-09 |
NCGC00015877-11 |
NCGC00015877-15 |
NCGC00022447-03 |
NCGC00022447-04 |
NCGC00022447-05 |
NCGC00178460-01 |
NCGC00261768-01 |
6-2-4-bis(4-fluorophenyl)methylene-1-piperidylethyl-7-methyl-thiazolo3,2-apyrimidin-5-one |
AC-30888 |
HY-10791 |
SY274388 |
SBI-0051053.P003 |
DB-056967 |
B6898 |
CS-0002823 |
EU-0101083 |
FT-0630948 |
R-103 |
D05738 |
AB00053288_14 |
051R432 |
A848404 |
L001003 |
R 55667R 55667 |
Q3937260 |
SR-01000000024-3 |
SR-01000000024-4 |
BRD-K40887525-001-02-9 |
BRD-K40887525-001-14-4 |
ethyl-7-methyl-5H-thiazolo3,2-apyrimidin-5-one |
6-2-4-bis(4-Fluorophenyl)methylene-1-piperidinyl- |
(+)-6-2-4-bis(4-fluorophenyl)methylene-1-piperidinylethyl-7-methyl-5H-thiazolo3,2-apyrimidin-5-one |
(ritanserin)6-(2-{4-Bis-(4-fluoro-phenyl)-methylene-piperidin-1-yl}-ethyl)-7-methyl-2,3-dihydro-1H-indolizin-5-one |
(ritanserin)6-(2-{4-Bis-(4-fluoro-phenyl)-methylene-piperidin-1-yl}-ethyl)-7-methyl-thiazolo3,2-apyrimidin-5-one |
6-(2-(4-Bis(4-fluorophenyl)methylene-1-piperidinyl)ethyl)-7-methyl-5H-1,3thiazolo3,2-apyrimidin-5-one # |
6-(2-{4-Bis-(4-fluoro-phenyl)-methylene-piperidin-1-yl}-ethyl)-7-methyl-8,8a-dihydro-thiazolo3,2-apyrimidin-5-one |
6-(2-{4-Bis-(4-fluoro-phenyl)-methylene-piperidin-1-yl}-ethyl)-7-methyl-thiazolo3,2-apyrimidin-5-one |
6-(2-{4-Bis-(4-fluoro-phenyl)-methylene-piperidin-1-yl}-ethyl)-7-methyl-thiazolo3,2-apyrimidin-5-one (Ritanserin) |
6-(2-{4-Bis-(4-fluoro-phenyl)-methylene-piperidin-1-yl}-ethyl)-7-methyl-thiazolo3,2-apyrimidin-5-one(Ritanserin) |
6-2-4-bis(4-fluorophenyl)-methylene-1-piperidinylethyl-7-methyl-5H-thiazolo3,2-a-pyrimidin-5-one |
E2J |
Experimental Data
ritanserin
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | -16 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
ritanserin
Statistics Data
ritanserin
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | -16 | 1 | 1 |
Statistics Data Visualization
ritanserin
