Compound Summary

  Compound Information
 NORDIHYDROGUAIARETIC ACID

Compound Name:

NORDIHYDROGUAIARETIC ACID

Compound CID:

4534

Synonyms:

NORDIHYDROGUAIARETIC ACID

500-38-9

NDGA

Dihydronorguaiaretic acid

Actinex

More...

Iupac Name:

4-[4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol

InChI:

InChI=1S/C18H22O4/c1-11(7-13-3-5-15(19)17(21)9-13)12(2)8-14-4-6-16(20)18(22)10-14/h3-6,9-12,19-22H,7-8H2,1-2H3

InChIKey:

HCZKYJDFEPMADG-UHFFFAOYSA-N

Canonical Smiles:

CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O

Isomeric Smiles:

CC(CC1=CC(=C(C=C1)O)O)C(C)CC2=CC(=C(C=C2)O)O

Molecular Weight:

302.4

Molecular Formula:

C18H22O4

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 NORDIHYDROGUAIARETIC ACID

Molecular Weight:

302.4

Molecular Formula:

C18H22O4

Hydrogen Bond Donor Count:

4

Hydrogen Bond Acceptor Count:

4

Rotatable Bond Count:

5

Heavy Atom Count:

22

Complexity:

303

  Synonyms
 NORDIHYDROGUAIARETIC ACID

NORDIHYDROGUAIARETIC ACID NORDIHYDROGUAIARETIC ACID

NORDIHYDROGUAIARETIC ACID

500-38-9

NDGA

Dihydronorguaiaretic acid

Actinex

4-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutylbenzene-1,2-diol

Nordihydroguairaretic acid

1,2-Benzenediol, 4,4-(2,3-dimethyl-1,4-butanediyl)bis-

Norhydroguaiaretic acid

Norguaiaretic acid, dihydro-

Dinorguaiaretic acid, dihydro-

4,4-(2,3-Dimethyltetramethylene)dipyrocatechol

NSC 4291

2,3-Bis(3,4-dihydroxyphenylmethyl)butane

nordihydroguaretic acid

Pyrocatechol, 4,4-(2,3-dimethyltetramethylene)di-

27686-84-6

4,4-(2,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)

CHEMBL52

Nordihydroguaiaretic acid (unspecified)

Butane, 1,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-

MLS000069451

CHEBI:7625

beta,gamma-Dimethyl-alpha,delta-bis(3,4-dihydroxyphenyl)butane

NSC4291

CHX 100; Masoprocol; meso-NDGA

1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane

MFCD00002206

NSC682984

4,4-(2,3-dimethylbutane-1,4-diyl)dibenzene-1,2-diol"

4,4-(2,3-dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)

SMR000059049

nordihydroguaiaretic acid (ndga)

CCRIS 1399

103185-28-0

NDGA, Larrea divaricata

EINECS 207-903-0

Norguaiaretic acid, dihydro

NSC 682984

NSC-4291

AI3-23059

NDGA;Masoprocol

NSC-682984

NCGC00015741-06

2,3-Dimethyl-1,4-bis(3,4-dihydroxyphenyl)butane

LOX inhibitor, N/A

nordihydroguiaretic acid

Spectrum_001146

4,4-(2,3-Dimethyl-1,4-butanediyl)bis(1,2-benzenediol)

nordihydroguajaretic acid

Spectrum5_000735

DSSTox_CID_2437

cid_4534

DSSTox_RID_76590

DSSTox_GSID_22437

Oprea1_368609

KBioGR_002349

KBioSS_001626

KBioSS_002352

MLS002153435

MLS006011710

DivK1c_000999

SCHEMBL135976

ACMC-20m628

GTPL4265

DTXSID5022437

rel-4,4-((2R,3S)-2,3-Dimethylbutane-1,4-diyl)bis(benzene-1,2-diol)

BDBM32020

HCZKYJDFEPMADG-UHFFFAOYSA-

HMS503G19

KBio1_000999

KBio2_001626

KBio2_002349

KBio2_004194

KBio2_004917

KBio2_006762

KBio2_007485

KBio3_002828

Nordihydro Guaiaretic Acid-d6

4,4-(2,3-Dimethyl-1,4-butanediyl)bis-1,2-benzenediol

cMAP_000026

NINDS_000999

HMS2232L16

HMS3370G10

HMS3649M15

BCP08590

HY-N0198

Tox21_302171

4-4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butylbenzene-1,2-diol

CN0046

s3984

SBB005930

STL570288

AKOS003367978

CCG-207935

CS-1431

MCULE-7119316381

SDCCGSBI-0050852.P002

IDI1_000999

NDGA - CAS 500-38-9

SMP2_000272

4,3-Dimethyltetramethylene)dipyrocatechol

NCGC00015741-04

NCGC00015741-05

NCGC00015741-08

NCGC00015741-09

NCGC00015741-13

NCGC00089785-02

NCGC00089785-03

NCGC00255380-01

AC-24202

AS-58406

CAS-500-38-9

NCI60_003992

ST056220

WLN: QR BQ D1Y1&Y1&1R CQ DQ

XN163193

D0800

FT-0606781

Nordihydroguaiaretic acid, >=97.0% (HPLC)

.beta.,.delta.-bis(3,4-dihydroxyphenyl)butane

4,3-Dimethyl-1,4-butanediyl)bis(pyrocatechol)

F17140

N-8500

1, 4,4-(2,3-dimethyl-1,4-butanediyl)bis-"

Pyrocatechol,4-(2,3-dimethyltetramethylene)di-

500N389

A913176

Butane,4-bis(3,4-dihydroxyphenyl)-2,3-dimethyl-

SR-01000003007

Q7050774

SR-01000003007-2

PYROCATECHOL,4- (2,3-DIEMTHYLTETRAMETHYLENE) DI-

4-4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butylpyrocatechol

.beta.,.gamma.-Dimethyl-.alpha.,.delta.-bis(3,4-dihydroxyphenyl)butane

1,2-Benzenediol, 4,4-(2R,3R)-2,3-dimethyl-1,4-butanediylbis-"

4,4-(2,3-dimethyltetramethylene)dipyrocatechol (Nordihydroguaiaretic acid)

4-4-3,4-bis(oxidanyl)phenyl-2,3-dimethyl-butylbenzene-1,2-diol

Nordihydroguaiaretic acid, >=90% (HPLC), from Larrea divaricata (creosote bush)

  Experimental Data
 NORDIHYDROGUAIARETIC ACID

Species Dosage Unit CG Lifespan(AVG/MED days) TG Lifespan(AVG/MED days) Lifespan Change(AVG/MED%) CG Lifespan(MAX days) TG Lifespan(MAX days) Lifespan Change(MAX%) Significant Strain Gender PubMed Active Label
Caenorhabditis elegans 100 umol/L 17.08 14.33 -16.08 NS N2 33008901 Inactive
Caenorhabditis elegans 10 umol/L 17.22 13.55 -21.33 NS N2 33008901 Inactive
Drosophila melanogaster 200 umol/L 44.8 43.88 -2.052 NS MALES 33008901 Inactive
Caenorhabditis elegans 100 umol/L 21.4 S N2 31602311 Active
Drosophila melanogaster 20 umol/L 45.44 46.5 2.326 NS FEMALES 33008901 Inactive
Mus musculus 5000 ppm 900 874 -3 1111 1077 -3 NS C2010 FEMALES 27312235 Inactive
Mus musculus 2.5 g/kg 786 881 12 S UM-HET3 MALES 18631321 Active
Mus musculus 1.5 g/kg 983 969 -0.01 NS B6C3F1 MALES 25380600 Inactive
Mus musculus 373 mg/kg 12 S B6C3F1 MALES 25380600 Active
Mus musculus 2.5 g/kg 983 1059 0.08 NS B6C3F1 MALES 25380600 Inactive
Mus musculus 800 ppm 789 831 6 1085 1103 2 S C2010 MALES 27312235 Active
Mus musculus 5000 ppm 789 839 9 1085 1108 2 S C2010 MALES 27312235 Active
Aedes aegypti 0.005 % 33 35.2 6.67 Unclear FEMALES 3749035
Mus musculus 3.5 g/kg 983 1099 0.12 S B6C3F1 MALES 25380600 Active
Mus musculus 2500 ppm 789 851 10 1085 1080 0 S C2010 MALES 27312235 Active
Mus musculus 4.5 g/kg 983 995 0.01 NS B6C3F1 MALES 25380600 Inactive
Drosophila melanogaster 3 mg/mL 23 S Oregon-R-C 25380600 Active
Aedes aegypti 0.001 % 14.3 16 11.89 Unclear MALES 3749035
Drosophila melanogaster 0.5 % 40.7 45.6 12.04 Unclear 6821144
Aedes aegypti 0.01 % 33 37.5 13.63 Unclear FEMALES 3749035
Aedes aegypti 0.005 % 14.3 23.5 64.3 Unclear MALES 3749035
Aedes aegypti 0.001 % 33 47.1 42.72 Unclear FEMALES 3749035
  Experimental Data Visualization
 NORDIHYDROGUAIARETIC ACID

  Statistics Data
 NORDIHYDROGUAIARETIC ACID

Species Lifespan Change(AVG/MED%) Lifespan Change(MAX%) Count Reference Count Data point
Aedes aegypti 64.3 1 5
Caenorhabditis elegans 21.4 2 3
Drosophila melanogaster 23 3 4
Mus musculus 12 2 3 10
  Statistics Data Visualization
 NORDIHYDROGUAIARETIC ACID

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