Compound Summary
Compound Information
SB 228357
Compound Name: | SB 228357 |
Compound CID: | 443390 |
Synonyms: | SB 228357 181629-93-6 SB-228357 SB228357 UNII-5RDN2E8E97 More... |
Iupac Name: | N-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
InChI: | InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30) |
InChIKey: | RRJLJKRFFRZRAF-UHFFFAOYSA-N |
Canonical Smiles: | COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F |
Isomeric Smiles: | COC1=C(C=C2C(=C1)CCN2C(=O)NC3=CC(=CC(=C3)C4=CN=CC=C4)F)C(F)(F)F |
Molecular Weight: | 431.4 |
Molecular Formula: | C22H17F4N3O2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
SB 228357
Molecular Weight: | 431.4 |
Molecular Formula: | C22H17F4N3O2 |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 7 |
Rotatable Bond Count: | 3 |
Heavy Atom Count: | 31 |
Complexity: | 634 |
Synonyms
SB 228357
| SB 228357 | SB 228357 |
|---|---|
SB 228357 |
181629-93-6 |
SB-228357 |
SB228357 |
UNII-5RDN2E8E97 |
Tocris-1375 |
CHEMBL14276 |
5RDN2E8E97 |
CHEBI:8979 |
N-(3-Fluoro-5-(pyridin-3-yl)phenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide |
1H-Indole-1-carboxamide, N-(3-fluoro-5-(3-pyridinyl)phenyl)-2,3-dihydro-5-methoxy-6-(trifluoromethyl)- |
N-3-FLUORO-5-(3-PYRINDYL)PHENYL-2,3-DIHYDRO-5-METHOXY-6-(TRIFLUOROMETHYL)-1H-INDOLE-1-CARBOXAMIDE |
N-(3-(3-Pyridinyl)-5-fluorophenyl)-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide |
N-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydroindole-1-carboxamide |
N-3-Fluoro-5-(3-pyridinyl)phenyl-5-methoxy-6-(trifluoromethyl)-1-indolinecarboxamide |
N-3-fluoro-5-(3-pyridyl)phenyl-5-methoxy-6-(trifluoromethyl)indoline-1-carboxamide |
1H-Indole-1-carboxamide, N-3-fluoro-5-(3-pyridinyl)phenyl-2,3-dihydro-5-methoxy-6-(trifluoromethyl)- |
SR-01000075936 |
Lopac-S-2318 |
J1.060.588A |
GTPL192 |
SCHEMBL7042732 |
DTXSID9042621 |
HMS3267B20 |
HMS3412K04 |
HMS3676K04 |
ZINC601841 |
BDBM50086056 |
AKOS024456558 |
CCG-204709 |
SB66061 |
VI30417 |
1-5(-fluoro-3-(3-pyridyl)phenyl-carbamoyl)-5-methoxy-6-trifluoromethylindoline |
NCGC00015935-01 |
NCGC00015935-02 |
NCGC00015935-03 |
NCGC00015935-04 |
NCGC00015935-05 |
NCGC00015935-07 |
NCGC00025130-01 |
NCGC00025130-02 |
NCGC00025130-03 |
N-3-Fluoro-5-(3-pyridinyl)phenyl-2,3-dihydro-5-methoxy-6-(trifluoromethyl)-1H-indole-1-carboxamide |
DB-044432 |
HY-103154 |
B6709 |
CS-0024682 |
EU-0100620 |
FT-0643749 |
S 2318 |
A812626 |
L001214 |
J-011603 |
SR-01000075936-1 |
SR-01000075936-3 |
BRD-K15424032-001-01-0 |
Q27088713 |
1H-Indole-1-carboxamide,N-3-fluoro-5-(3-pyridinyl)phenyl-2,3-dihydro-5-methoxy-6-(trifluoromethyl)- |
5-Methoxy-6-trifluoromethyl-2,3-dihydro-indole-1-carboxylic acid (3-fluoro-5-pyridin-3-yl-phenyl)-amide |
N-(3-fluoro-5-pyridin-3-ylphenyl)-5-methoxy-6-(trifluoromethyl)-2,3-dihydro-1H-indole-1-carboxamide |
N-3-Fluoro-5-(3-pyridyl)phenyl-2,3-dihydro-5-methoxy-6(trifluoromethyl)-1H-indole-1-carboxamide |
Experimental Data
SB 228357
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 15 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
SB 228357
Statistics Data
SB 228357
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 15 | 1 | 1 |
Statistics Data Visualization
SB 228357
