Compound Summary

  Compound Information
 metformin

Compound Name:

metformin

Compound CID:

4091

Synonyms:

metformin

657-24-9

1,1-Dimethylbiguanide

N,N-dimethylimidodicarbonimidic diamide

Metformine

More...

Iupac Name:

3-(diaminomethylidene)-1,1-dimethylguanidine

InChI:

InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)

InChIKey:

XZWYZXLIPXDOLR-UHFFFAOYSA-N

Canonical Smiles:

CN(C)C(=N)N=C(N)N

Isomeric Smiles:

CN(C)C(=N)N=C(N)N

Molecular Weight:

129.16

Molecular Formula:

C4H11N5

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 metformin

Molecular Weight:

129.16

Molecular Formula:

C4H11N5

Hydrogen Bond Donor Count:

3

Hydrogen Bond Acceptor Count:

1

Rotatable Bond Count:

2

Heavy Atom Count:

9

Complexity:

132

  Synonyms
 metformin

metformin metformin

metformin

657-24-9

1,1-Dimethylbiguanide

N,N-dimethylimidodicarbonimidic diamide

Metformine

Metiguanide

Dimethylbiguanide

Haurymelin

Fluamine

Flumamine

Gliguanid

Diabex

Melbin

N,N-Dimethylbiguanide

Glumetza

Imidodicarbonimidic diamide, N,N-dimethyl-

N1,N1-Dimethylbiguanide

DMGG

NNDG

N,N-Dimethyldiguanide

3-(diaminomethylidene)-1,1-dimethylguanidine

1,1-Dimethyl biguanide

LA-6023

BIGUANIDE, 1,1-DIMETHYL-

Fortamet

UNII-9100L32L2N

CHEMBL1431

CHEBI:6801

Glifage

Islotin

Siofor

Dimethyldiguanide

Diaformin

9100L32L2N

Metformina DCIT

Metforminum

Metformina

Metformina Spanish

Metformine INN-French

Metforminum INN-Latin

Metformin USAN:INN:BAN

MLS000028493

14Cmetformin

14C-metformin

C4H11N5

657M249

Metformin (USAN/INN)

NCGC00016564-01

SMR000058277

EINECS 211-517-8

CAS-1115-70-4

Dianben

Obimet

Dimethylbiguanid

Metformin base

CCRIS 9321

N-dimethylbiguanide

DMBG

Glucophage (Salt/Mix)

n,n-dimethylbiguanide

Imidodicarbonimidic diamide-, N,N-dimethyl-

Prestwick0_000004

Prestwick1_000004

Prestwick2_000004

Prestwick3_000004

DSSTox_CID_3270

N,N-Dimethylguanylguanidin

SCHEMBL8944

DSSTox_RID_76950

DSSTox_GSID_23270

BSPBio_000007

BSPBio_002314

KBioGR_002310

KBioSS_002312

cid_14219

LA 6023 (Salt/Mix)

BIDD:GT0697

SPBio_001928

BPBio1_000009

GTPL4503

GTPL4779

SCHEMBL9913821

DTXSID2023270

SCHEMBL10276396

BDBM57047

KBio2_002310

KBio2_004878

KBio2_007446

KBio3_002790

cMAP_000016

HMS2089D19

HY-B0627

Tox21_302370

BBL012337

BDBM50229665

HSCI1_000295

s5958

STK011633

STL483693

STL484070

ZINC12859773

AKOS000121065

AKOS005206848

AKOS015966566

CCG-102605

DB00331

MCULE-7393156510

3-carbamimidoyl-1,1-dimethyl-guanidine

NCGC00016564-02

NCGC00016564-03

NCGC00016564-05

NCGC00016564-07

NCGC00188959-01

NCGC00255255-01

AC-32484

AS-65365

CAS-657-24-9

K070

SBI-0206876.P001

1-carbamimidamido-N,N-dimethylmethanimidamide

CS-0009563

FT-0628266

A19551

C07151

D04966

D72476

Q19484

(E)-3-Amino(dimethylamino)methylideneguanidine

1-(E)-amino(dimethylamino)methylideneguanidine

15673-EP2269977A2

15673-EP2269989A1

15673-EP2270007A1

15673-EP2270011A1

15673-EP2272825A2

15673-EP2272834A1

15673-EP2272841A1

15673-EP2275108A1

15673-EP2275414A1

15673-EP2280001A1

15673-EP2287165A2

15673-EP2287166A2

15673-EP2292228A1

15673-EP2292620A2

15673-EP2295406A1

15673-EP2295409A1

15673-EP2295411A1

15673-EP2295422A2

15673-EP2298742A1

15673-EP2298769A1

15673-EP2298772A1

15673-EP2298776A1

15673-EP2298779A1

15673-EP2301533A1

15673-EP2301923A1

15673-EP2301929A1

15673-EP2301935A1

15673-EP2301936A1

15673-EP2305648A1

15673-EP2305674A1

15673-EP2308839A1

15673-EP2308847A1

15673-EP2308878A2

15673-EP2314576A1

15673-EP2314588A1

15673-EP2316470A2

W-109589

BRD-K79602928-003-04-1

BRD-K79602928-003-08-2

3-(diaminomethylene)-1,1-dimethyl-guanidine;hydrochloride

3-bis(azanyl)methylidene-1,1-dimethyl-guanidine;hydrochloride

MF8

  Experimental Data
 metformin

Species Dosage Unit CG Lifespan(AVG/MED days) TG Lifespan(AVG/MED days) Lifespan Change(AVG/MED%) CG Lifespan(MAX days) TG Lifespan(MAX days) Lifespan Change(MAX%) Significant Strain Gender PubMed Active Label
Drosophila melanogaster 5 mM 36 40 0.11 S w1118 36394755 Active
Drosophila melanogaster 10 mM 36 36 0 NS w1118 36394755 Inactive
Mus musculus 1 % -1 -6 S C57BL/6J 29167747 Inactive
Mus musculus 706 742 5.1 930 966 3.9 S 129/Sv FEMALES 21084729 Active
Caenorhabditis elegans 50 mM 17.94 22.42 0.25 S N2 27984722 Active
Acheta domesticus 0.00178 g 41.4 74.1 0.79 136 188 0.38 S 25833406 Active
Mus musculus 1000 ppm 874 872 0 1092 1094 0 NS C2011 FEMALES 27312235 Inactive
Mus musculus 1000 ppm 780 835 7 1064 1046 -2 NS C2011 MALES 27312235 Inactive
Drosophila melanogaster 1 mM 57 59 0.04 NS Dahomey MALES 23077661 Inactive
Caenorhabditis elegans 20 mM 14 16 14.3 S N2 29263362 Active
Mus musculus 100 mg/kg 264 285 8 311 340 16.2 S FVB/N FEMALES 21084729 Active
Drosophila melanogaster 5 mM 54 58 0.07 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 10 mM 54 51 -0.06 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 10 mM 65 63 -0.03 NS Dahomey FEMALES 23077661 Inactive
Mus musculus 1 % -5 -3 S C57BL/6J 29167747 Inactive
Drosophila melanogaster 5 mM 65 65 0 NS Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 5 mM 57 57 0 NS Dahomey MALES 23077661 Inactive
Mus musculus 662 573 -13.4 1029 1044 0.01 S 129/Sv MALES 21084729 Inactive
Caenorhabditis elegans 20 mM 15 17 13.3 S N2 29263362 Active
Drosophila melanogaster 25 mM 54 51 -0.06 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 2.5 mM 67 67 0 NS Dahomey FEMALES 23077661 Inactive
Mus musculus 0.1 % 5.83 S C57BL/6 MALES 23900241 Active
Caenorhabditis elegans 50 mM 43.65 S N2 29027899 Active
Caenorhabditis elegans 50 mM 15 21 40 0 S N2 20090912 Active
Mus musculus 1 % -14.4 S C57BL/6 MALES 23900241 Inactive
Acheta domesticus 0.00178 g 97.9 143.7 0.47 130 188 0.45 S 25833406 Active
Drosophila melanogaster 5 mM 67 67 0 NS Dahomey FEMALES 23077661 Inactive
Mus musculus 388 535 37.9 814 898 10.3 S SHR FEMALES 21084729 Active
Mus musculus 285 304 0.07 396 359 -0.09 NS FVB/N FEMALES 21084729 Inactive
Drosophila melanogaster 100 mM 54 37 -0.31 S Dahomey MALES 23077661 Inactive
Drosophila melanogaster 50 mM 54 51 -0.06 NS Dahomey MALES 23077661 Inactive
Drosophila melanogaster 50 mM 65 51 -0.22 S Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 25 mM 65 58 -0.11 S Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 100 mM 65 22 -0.66 S Dahomey FEMALES 23077661 Inactive
Caenorhabditis elegans 100 mM 16 17.7 0.11 NS N2 24889636 Inactive
Acheta domesticus 0.00178 g 88.9 123.2 0.39 136 183 0.35 S 25833406 Active
Caenorhabditis elegans 50 mM 16 17.9 0.12 NS N2 24889636 Inactive
Drosophila melanogaster 1 mM 67 67 0 NS Dahomey FEMALES 23077661 Inactive
Drosophila melanogaster 2.5 mM 57 55 -0.04 NS Dahomey MALES 23077661 Inactive
Caenorhabditis elegans 25 mM 16 21.5 0.34 S N2 24889636 Active
Caenorhabditis elegans 6.25 mM 16 19 0.19 S N2 24889636 Active
Caenorhabditis elegans 12.5 mM 16 18 0.12 S N2 24889636 Active
Caenorhabditis elegans 25 mM 18 S N2 23540700 Active
Caenorhabditis elegans 50 mM 36 S N2 23540700 Active
Caenorhabditis elegans 100 mM 3 S N2 23540700 Active
  Experimental Data Visualization
 metformin

  Statistics Data
 metformin

Species Lifespan Change(AVG/MED%) Lifespan Change(MAX%) Count Reference Count Data point
Acheta domesticus 0.79 0.45 1 3
Caenorhabditis elegans 43.65 0 6 13
Drosophila melanogaster 0.11 2 18
Mus musculus 37.9 16.2 4 11
  Statistics Data Visualization
 metformin

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