Compound Summary
Compound Information
lamotrigine
Compound Name: | lamotrigine |
Compound CID: | 3878 |
Synonyms: | lamotrigine 84057-84-1 6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine Lamictal Lamictal Cd More... |
Iupac Name: | 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
InChI: | InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16) |
InChIKey: | PYZRQGJRPPTADH-UHFFFAOYSA-N |
Canonical Smiles: | C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N |
Isomeric Smiles: | C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N |
Molecular Weight: | 256.09 |
Molecular Formula: | C9H7Cl2N5 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
lamotrigine
Molecular Weight: | 256.09 |
Molecular Formula: | C9H7Cl2N5 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 1 |
Heavy Atom Count: | 16 |
Complexity: | 242 |
Synonyms
lamotrigine
| lamotrigine | lamotrigine |
|---|---|
lamotrigine |
84057-84-1 |
6-(2,3-Dichlorophenyl)-1,2,4-triazine-3,5-diamine |
Lamictal |
Lamictal Cd |
Lamictal XR |
Lamotriginum Latin |
Lamotrigina Spanish |
Lamotriginum |
BW 430C |
Lamotrigina |
Lamictal ODT |
BW-430C |
3,5-Diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine |
1,2,4-Triazine-3,5-diamine, 6-(2,3-dichlorophenyl)- |
BW430C |
3,5-Diamino-6-(2,3-dichlorophenyl)-as-triazine |
C9H7Cl2N5 |
LTG;BW430C |
UNII-U3H27498KS |
MFCD00865333 |
CHEMBL741 |
MLS000069685 |
CHEBI:6367 |
U3H27498KS |
NCGC00015605-06 |
Labileno |
Lamitor |
SMR000058464 |
DSSTox_CID_3195 |
DSSTox_RID_76918 |
DSSTox_GSID_23195 |
Lamictal (TN) |
LTg |
CAS-84057-84-1 |
SR-01000000187 |
EINECS 281-901-8 |
HSDB 7526 |
EUR-1048 |
Lamotrigine USAN:USP:INN:BAN |
zine-3,5-diamine |
Lamotrigine- Bio-X |
GI 267119X |
Lamotrigine-13C-d3 |
Opera_ID_12 |
Tocris-1611 |
hydroxymethyl progesterone |
Lopac-L-3791 |
L 3791 |
Lopac0_000688 |
SCHEMBL35439 |
MLS000759486 |
MLS001077325 |
MLS001423991 |
BIDD:GT0794 |
Lamotrigine (JAN/USP/INN) |
Lamotrigine, >=98%, powder |
GTPL2622 |
DTXSID2023195 |
ZINC13156 |
HMS2051C10 |
HMS2089M08 |
HMS2093P21 |
HMS2230L04 |
HMS3262I17 |
HMS3268G17 |
HMS3371O16 |
HMS3393C10 |
HMS3657A17 |
HMS3715H21 |
HMS3885M03 |
Pharmakon1600-01505610 |
AMY40805 |
BCP12156 |
HY-B0495 |
Lamotrigine 1.0 mg/ml in Methanol |
Tox21_110179 |
Tox21_500688 |
BDBM50031299 |
NSC746307 |
NSC759171 |
s3024 |
STK628377 |
AKOS005561147 |
Tox21_110179_1 |
6-(2,2,4-triazine-3,5-diyldiamine |
CCG-100856 |
DB00555 |
KS-1074 |
LP00688 |
MCULE-7648410888 |
NC00106 |
NSC 746307 |
NSC 759171 |
NSC-746307 |
NSC-759171 |
SDCCGSBI-0050666.P003 |
SMP2_000303 |
NCGC00015605-01 |
NCGC00015605-02 |
NCGC00015605-03 |
NCGC00015605-04 |
NCGC00015605-05 |
NCGC00015605-07 |
NCGC00015605-08 |
NCGC00015605-09 |
NCGC00015605-10 |
NCGC00015605-23 |
NCGC00015605-24 |
NCGC00022936-02 |
NCGC00022936-04 |
NCGC00022936-05 |
NCGC00261373-01 |
AC-10298 |
AC-32483 |
AT-15488 |
BL166799 |
K499 |
Lamotrigine 100 microg/mL in Acetonitrile |
SBI-0050666.P002 |
6-(2,3-Dichloro-phenyl)-1,2,4tria |
AB0014255 |
DB-014839 |
B2249 |
EU-0100688 |
FT-0602546 |
FT-0670713 |
FT-0670714 |
L-205 |
L0241 |
SW197486-3 |
57L841 |
A11873 |
D00354 |
J10032 |
W13018 |
AB00384359-16 |
AB00384359_17 |
AB00384359_18 |
A840709 |
Q410346 |
3,5-diamino-(2,3-dichlorophenyl)-1,2,4-triazine |
Q-201221 |
SR-01000000187-2 |
SR-01000000187-4 |
SR-01000000187-7 |
BRD-K93460210-071-01-6 |
SR-01000000187-10 |
3,5-diamino-6-(2,3,-dichlorophenyl)-1,2,4-triazine |
6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine. |
F2173-0540 |
Z1550648755 |
6-(2,3-Dichloro-phenyl)-1,2,4triazine-3,5-diamine |
6-2,3-bis(chloranyl)phenyl-1,2,4-triazine-3,5-diamine |
Lamotrigine, British Pharmacopoeia (BP) Reference Standard |
Lamotrigine, European Pharmacopoeia (EP) Reference Standard |
6-(2,3-Dichloro-phenyl)-1,2,4triazine-3,5-diamine(lamotrigine) |
GI 267119X; 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine |
Lamotrigine, United States Pharmacopeia (USP) Reference Standard |
Lamotrigine, Pharmaceutical Secondary Standard; Certified Reference Material |
Lamotrigine for peak identification, European Pharmacopoeia (EP) Reference Standard |
Lamotrigine for system suitability, European Pharmacopoeia (EP) Reference Standard |
Lamotrigine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material |
Experimental Data
lamotrigine
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 200 | umol/L | 46.39 | 47.89 | 3.24 | NS | MALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 33 | umol/L | -3 | NS | N2 | 24134630 | Inactive | ||||||
| Drosophila melanogaster | 6 | mg/mL | 21.6 | 24.3 | 0.12 | 36.8 | 38.4 | 0.04 | S | Ives | MALES | 19430925 | Active |
| Drosophila melanogaster | 12 | mg/mL | 21.6 | 24.9 | 0.15 | 36.8 | 43.3 | 0.18 | S | Ives | MALES | 19430925 | Active |
| Drosophila melanogaster | 20 | umol/L | 54.37 | 57.31 | 5.41 | NS | FEMALES | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 100 | umol/L | 16.8 | 16.31 | -2.916 | NS | N2 | 33008901 | Inactive | ||||
| Caenorhabditis elegans | 10 | umol/L | 16.59 | 17.33 | 4.46 | NS | N2 | 33008901 | Inactive | ||||
| Drosophila melanogaster | 6 | mg/mL | 24.3 | 27.4 | 0.13 | 40.7 | 41.3 | 0.01 | S | Ives | FEMALES | 19430925 | Active |
| Drosophila melanogaster | 12 | mg/mL | 24.3 | 28.5 | 0.17 | 40.7 | 47 | 0.15 | S | Ives | FEMALES | 19430925 | Active |
Experimental Data Visualization
lamotrigine
Statistics Data
lamotrigine
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 4.46 | 2 | 3 | |
| Drosophila melanogaster | 5.41 | 0.18 | 2 | 6 |
Statistics Data Visualization
lamotrigine
