Compound Summary
Compound Information
Fasudil
Compound Name: | Fasudil |
Compound CID: | 3547 |
Synonyms: | Fasudil 103745-39-7 HA1077 ha-1077 HA 1077 More... |
Iupac Name: | 5-(1,4-diazepan-1-ylsulfonyl)isoquinoline |
InChI: | InChI=1S/C14H17N3O2S/c18-20(19,17-9-2-6-15-8-10-17)14-4-1-3-12-11-16-7-5-13(12)14/h1,3-5,7,11,15H,2,6,8-10H2 |
InChIKey: | NGOGFTYYXHNFQH-UHFFFAOYSA-N |
Canonical Smiles: | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3 |
Isomeric Smiles: | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CN=C3 |
Molecular Weight: | 291.37 |
Molecular Formula: | C14H17N3O2S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
Fasudil
Molecular Weight: | 291.37 |
Molecular Formula: | C14H17N3O2S |
Hydrogen Bond Donor Count: | 1 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 2 |
Heavy Atom Count: | 20 |
Complexity: | 421 |
Synonyms
Fasudil
| Fasudil | Fasudil |
|---|---|
Fasudil |
103745-39-7 |
HA1077 |
ha-1077 |
HA 1077 |
AT 877 |
Fasudilum |
1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)- |
5-(1,4-diazepan-1-ylsulfonyl)isoquinoline |
AT-877 |
Fasudil INN |
1-(5-Isoquinolinesulfonyl)homopiperazine |
5-(1,4-diazepane-1-sulfonyl)isoquinoline |
UNII-Q0CH43PGXS |
AT877 |
Hexahydro-1-(5-isoquinolinylsulfonyl)-1H-1,4-diazepine |
Q0CH43PGXS |
5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE |
Fasudil dihydrochloride |
CHEMBL38380 |
Fasudil (INN) |
Eril |
ZK-258594 |
BRD7868 |
BRD-7868 |
Fasudilum INN-Latin |
M77 |
MFCD00866182 |
NCGC00018100-04 |
2esm |
2gni |
zlchem 7 |
dihydrochloride fasudil |
Kinome_3390 |
Kinome_3391 |
Tocris-0541 |
1q8w |
ACMC-20dih9 |
BiomolKI_000038 |
5-((1,4-diazepan-1-yl)sulfonyl)isoquinoline |
BiomolKI2_000046 |
Fasudil (HA-1077) |
SCHEMBL4674 |
BSPBio_001111 |
KBioGR_000451 |
KBioSS_000451 |
MLS006011953 |
cid_163751 |
GTPL5181 |
Hexahydro-1-(5-isoquinolylsulfonyl)-1H-1,4-diazepine |
ZINC6486 |
DTXSID4048569 |
BDBM14027 |
CHEBI:43871 |
KBio2_000451 |
KBio2_003019 |
KBio2_005587 |
KBio3_000841 |
KBio3_000842 |
5-(Hexahydro-1H-1,4-diazepin-1-yl)sulfonylisoquinoline |
ZLA0008 |
BCPP000234 |
Bio2_000386 |
Bio2_000866 |
HMS1362G13 |
HMS1792G13 |
HMS1990G13 |
HMS2089F13 |
HMS3264M10 |
Pharmakon1600-01502366 |
ACT06297 |
BCP26821 |
3668AH |
HY-10341A |
NSC759827 |
NSC800098 |
AKOS009604905 |
AC-4279 |
AT27735 |
BCP9000678 |
CCG-100642 |
DB08162 |
MCULE-1374831127 |
NSC 759827 |
NSC-759827 |
NSC-800098 |
IDI1_002141 |
SMP2_000083 |
NCGC00018100-01 |
NCGC00018100-02 |
NCGC00018100-03 |
NCGC00018100-05 |
NCGC00018100-06 |
NCGC00018100-07 |
NCGC00024299-02 |
NCGC00024299-04 |
NCGC00024299-05 |
1-(5-Isoquinolinesulphonyl)homopiperazine |
1-(5-Isoquinolinylsulfonyl)homopiperazine |
1-(isoquinoline-5-sulfonyl)homopiperazine |
AS-70114 |
SMR002529471 |
AB0109468 |
FT-0602399 |
EN300-68842 |
D07941 |
MLS-0003155.0001 |
AB00490076-08 |
AB00490076_09 |
1-(5-Isoquinolylsulfonyl)-1,4-diazaperhydroepine |
745F397 |
Q5437132 |
BRD-K76617868-001-02-2 |
BRD-K76617868-001-03-0 |
BRD-K76617868-300-03-6 |
BRD-K76617868-300-04-4 |
Fasudil; (5-ISOQUINOLINESULFONYL)HOMOPIPERAZINE |
hexahydro-1-(5-isoquinolinesulfonyl)-1h-1,4-diazepine |
Z1160899500 |
5-(Hexahydro-1H-1,4-diazepine-1-ylsulfonyl)isoquinoline |
1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)- (9CI) |
1-(5-Isoquinolinesulfonyl)-1H-hexahydro-1,4-diazepine, Dihydrochloride |
AT 877; AT-877; AT877; HA 1077; HA-1077; HA1077 |
Experimental Data
Fasudil
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Drosophila melanogaster | 10 | umol/L | 14.5 | S | Oregon-R | 22363408 | Active |
Experimental Data Visualization
Fasudil
Statistics Data
Fasudil
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Drosophila melanogaster | 14.5 | 1 | 1 |
Statistics Data Visualization
Fasudil
