Compound Summary
Compound Information
glyburide
Compound Name: | glyburide |
Compound CID: | 3488 |
Synonyms: | glyburide Glibenclamide 10238-21-8 Glybenclamide Glynase More... |
Iupac Name: | 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide |
InChI: | InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29) |
InChIKey: | ZNNLBTZKUZBEKO-UHFFFAOYSA-N |
Canonical Smiles: | COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
Isomeric Smiles: | COC1=C(C=C(C=C1)Cl)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NC3CCCCC3 |
Molecular Weight: | 494 |
Molecular Formula: | C23H28ClN3O5S |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
glyburide
Molecular Weight: | 494 |
Molecular Formula: | C23H28ClN3O5S |
Hydrogen Bond Donor Count: | 3 |
Hydrogen Bond Acceptor Count: | 5 |
Rotatable Bond Count: | 8 |
Heavy Atom Count: | 33 |
Complexity: | 746 |
Synonyms
glyburide
| glyburide | glyburide |
|---|---|
glyburide |
Glibenclamide |
10238-21-8 |
Glybenclamide |
Glynase |
Micronase |
Diabeta |
Daonil |
Euglucon |
Maninil |
Semi-daonil |
Apo-Glibenclamide |
Euglucon 5 |
Azuglucon |
Bastiverit |
Benclamin |
Betanase |
Duraglucon |
Euglucan |
Euglykon |
Glibenil |
Glucolon |
Orabetic |
Prodiabet |
Renabetic |
Yuglucon |
Dibelet |
Gilemal |
Glibens |
Glibil |
Glimel |
Glimide |
Humedia |
Libanil |
Suraben |
Tiabet |
Adiab |
Glybenzcyclamide |
Melix |
Pira |
Med-Glionil |
Glibenclamida |
Glibenclamidum |
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide |
Glibenclamidum INN-Latin |
Glibenclamida INN-Spanish |
HB 419 |
C23H28ClN3O5S |
UR 606 |
glyburide (glibenclamide) |
UNII-SX6K58TVWC |
1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea |
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea |
Neogluconin |
5-chloro-N-2-4-(cyclohexylcarbamoylsulfamoyl)phenylethyl-2-methoxybenzamide |
5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide |
U 26452 |
Gewaglucon |
Glibenbeta |
Glidiabet |
Glucobene |
Glucohexal |
Glucoremed |
Hexaglucon |
Lederglib |
Lisaglucon |
Normoglucon |
Praeciglucon |
Calabren |
Cytagon |
Euclamin |
Glamide |
Glibesyn |
Glibetic |
Gliboral |
Glisulin |
Glitisol |
Glubate |
Glucomid |
Glucoven |
Glycomin |
Miglucan |
Debtan |
Gliban |
Gliben |
Glibet |
Glicem |
Gluben |
Glyben |
Nadib |
Sugril |
SX6K58TVWC |
CHEMBL472 |
Novo-Glyburide |
Glibenclamid AL |
Gen-Glybe |
Norglicem 5 |
Betanese 5 |
N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N-cyclohexylurea |
Glibenclamid Fabra |
5-chloro-N-2-(4-{(cyclohexylcarbamoyl)aminosulfonyl}phenyl)ethyl-2-methoxybenzamide |
MLS000069721 |
CHEBI:5441 |
Glibenclamid Basics |
Glibenclamid-Cophar |
Glibenclamid Heumann |
Semi-Euglucon |
Glibenclamid Genericon |
Hemi-Daonil |
Glibenclamid-Ratiopharm |
5-chloro-N-(2-{4-(cyclohexylcarbamoyl)sulfamoylphenyl}ethyl)-2-methoxybenzamide |
Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl- |
MFCD00056625 |
Benzamide, 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxy- |
NCGC00015467-11 |
Abbenclamide |
Diabiphage |
Glibadone |
SMR000058229 |
Semi-Gliben-Puren N |
GBN 5 |
CAS-10238-21-8 |
Glibenclamid Riker M. |
Glyburide (micronized) |
5-Chloro-N-4-(cyclohexylureidosulfonyl)phenethyl-2-methoxybenzamide |
Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl- |
DSSTox_CID_17237 |
DSSTox_RID_79313 |
DSSTox_GSID_37237 |
Benzamide, 5-chloro-N-2-4-(cyclohexylamino)carbonylaminosulfonylphenylethyl-2-methoxy- |
Micronized glyburide |
U-26,452 |
Glycron |
1-p-2-(5-Chloro-o-anisamido)ethylphenylsulfonyl-3-cyclohexylurea |
5-chloro-N-(2-{4-N-(N-cyclohexylcarbamoyl)sulfamoylphenyl}ethyl)-2-methoxybenzamide |
5-Chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)-phenethyl)-2-methoxybenzamide |
Glyburide (USP) |
Micronase (TN) |
HB-419 |
1-{4-2-(5-chloro-2-methoxybenzamido)ethylbenzenesulfonyl}-3-cyclohexylurea;1-{4-2-(5-chloro-2-methoxybenzamido)ethylbenzenesulfonyl}-3-cyclohexylurea |
Diabeta (TN) |
Glynase (TN) |
SR-01000000196 |
Glyburide USAN:USP |
EINECS 233-570-6 |
BRN 2230085 |
Amglidia |
Delmide |
5-chloro-N-(4-N-(cyclohexylcarbamoyl)sulfamoylphenethyl)-2-methoxybenzamide |
Glibenclamide,(S) |
5-Chloro-N-2-4-(cyclohexylamino)carbonylaminosulfonylphenylethyl-2-methoxybenzamide |
GBM |
Prestwick_569 |
Glibenclamide B.P. |
Glyburide (Diabeta) |
Glibenclamide INN |
RP-1127 |
Spectrum_000250 |
Tocris-0911 |
Glibenclamide - Bio-X |
Glybenzcyclamide, 99% |
Glibenclamide; Glyburide |
Opera_ID_801 |
Prestwick0_000316 |
Prestwick1_000316 |
Prestwick2_000316 |
Prestwick3_000316 |
Spectrum2_001816 |
Spectrum3_001327 |
Spectrum4_001199 |
Spectrum5_001631 |
Lopac-G-0639 |
ACMC-20a66i |
Probes1_000431 |
Probes2_000378 |
UPCMLD-DP006 |
G 0639 |
Glibenclamide (JP17/INN) |
N-(4-(beta-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N-cyclohexyl-harnstoff |
CBiol_001790 |
Lopac0_000499 |
Oprea1_764617 |
SCHEMBL22009 |
U-26452 |
BSPBio_000312 |
BSPBio_001351 |
BSPBio_003053 |
KBioGR_000071 |
KBioGR_001897 |
KBioSS_000071 |
KBioSS_000730 |
MLS001077262 |
BIDD:GT0239 |
DivK1c_000481 |
SPECTRUM2300229 |
SPBio_001831 |
SPBio_002531 |
BPBio1_000344 |
GTPL2414 |
DTXSID0037237 |
UPCMLD-DP006:001 |
HMS501I03 |
KBio1_000481 |
KBio2_000071 |
KBio2_000730 |
KBio2_002639 |
KBio2_003298 |
KBio2_005207 |
KBio2_005866 |
KBio3_000141 |
KBio3_000142 |
KBio3_002273 |
AOB6214 |
SYN3026 |
Glybenclamide, >=99% (HPLC) |
NINDS_000481 |
Bio1_000076 |
Bio1_000565 |
Bio1_001054 |
Bio2_000071 |
Bio2_000551 |
HMS1361D13 |
HMS1568P14 |
HMS1791D13 |
HMS1922L08 |
HMS1989D13 |
HMS2089L06 |
HMS2093P04 |
HMS2095P14 |
HMS3259O12 |
HMS3261D19 |
HMS3267A15 |
HMS3402D13 |
HMS3411F16 |
HMS3428D15 |
HMS3651E17 |
HMS3675F16 |
HMS3712P14 |
Pharmakon1600-02300229 |
ZINC537805 |
BCP05327 |
Tox21_110158 |
Tox21_300758 |
Tox21_500499 |
BDBM50012957 |
CCG-39618 |
HD 419 |
NSC759618 |
SBB057426 |
STK362992 |
Glyburide - CAS 10238-21-8 |
AKOS001487495 |
N-p-2-(5-Chloro-2-methoxybenzamido)ethylbenzenesulfonyl-N-cyclohexylurea |
Tox21_110158_1 |
BCP9000729 |
CS-1075 |
DB01016 |
KS-5326 |
LP00499 |
MCULE-2351642942 |
NC00566 |
NSC 759618 |
NSC-759618 |
SB17414 |
SDCCGSBI-0050483.P004 |
IDI1_000481 |
IDI1_033821 |
Glibenclamide 1.0 mg/ml in Acetonitrile |
NCGC00015467-01 |
NCGC00015467-02 |
NCGC00015467-03 |
NCGC00015467-04 |
NCGC00015467-05 |
NCGC00015467-06 |
NCGC00015467-07 |
NCGC00015467-08 |
NCGC00015467-09 |
NCGC00015467-10 |
NCGC00015467-12 |
NCGC00015467-13 |
NCGC00015467-14 |
NCGC00015467-15 |
NCGC00015467-16 |
NCGC00015467-17 |
NCGC00015467-18 |
NCGC00015467-20 |
NCGC00015467-21 |
NCGC00015467-36 |
NCGC00015467-37 |
NCGC00016689-01 |
NCGC00023447-02 |
NCGC00023447-04 |
NCGC00023447-05 |
NCGC00023447-06 |
NCGC00023447-07 |
NCGC00023447-08 |
NCGC00023447-09 |
NCGC00023447-10 |
NCGC00023447-11 |
NCGC00023447-12 |
NCGC00254662-01 |
NCGC00261184-01 |
5-Chloro-N-2-4-(cyclohexylamino)carbonyl-aminosulfonylphenyl-ethyl-2-methoxybenzamide |
BG166164 |
HY-15206 |
ST024780 |
SBI-0050483.P003 |
AB0012611 |
Glyburide, meets USP testing specifications |
AB00051949 |
EU-0100499 |
FT-0601608 |
G-150 |
G0382 |
S1716 |
SW195828-5 |
A19539 |
C07022 |
D00336 |
D81733 |
J10021 |
78637-EP2270001A1 |
78637-EP2270011A1 |
78637-EP2272825A2 |
78637-EP2272841A1 |
78637-EP2275414A1 |
78637-EP2287165A2 |
78637-EP2287166A2 |
78637-EP2292620A2 |
78637-EP2298750A1 |
78637-EP2298776A1 |
78637-EP2298779A1 |
78637-EP2301923A1 |
78637-EP2301936A1 |
78637-EP2305648A1 |
78637-EP2308847A1 |
AB00051949-16 |
AB00051949-17 |
AB00051949_18 |
AB00051949_19 |
Q420626 |
U-26,45 |
SR-01000000196-2 |
SR-01000000196-4 |
SR-01000000196-5 |
SR-01000000196-6 |
SR-01000000196-8 |
W-108874 |
BRD-K36927236-001-06-0 |
BRD-K36927236-001-17-7 |
Z277540138 |
Glybenclamide, European Pharmacopoeia (EP) Reference Standard |
Glyburide, United States Pharmacopeia (USP) Reference Standard |
1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea |
5-Chloro-N-4-(3-cyclohexylureidosulfonyl)phenethyl-2-methoxybenzamide |
5-chloro-N-2-4-(cyclohexylcarbamoylsulfamoyl)phenylethyl-2-methoxybenzamide. |
5-chloro-N-4-({(cyclohexylamino)carbonylamino}sulfonyl)phenethyl-2-methoxybenzamide |
Glibenclamide for peak identification, European Pharmacopoeia (EP) Reference Standard |
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material |
N-(4-(.beta.-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N-cyclohexyl-harnstoff |
N1-4-({(cyclohexylamino)carbonylamino}sulfonyl)phenethyl-5-chloro-2-methoxybenzamide |
(5-chloro-2-methoxyphenyl)-N-2-(4-{(cyclohexylamino)carbonylaminosulfonyl}p henyl)ethylcarboxamide |
5-Chloro-N-(2-4-(((cyclohexylamino)carbonylamino)sulfonyl)phenylethyl)-2-methoxybenzamide # |
5-Chloro-N-2-4-(Cylcohexylamino)carbonylaminosulphonylphenylethyl-2-methoxybenzamide |
N-(4-{2-(5-chloro-2-methoxyphenyl)carbonylaminoethyl}phenyl)sulfonyl(cyclo hexylamino)carboxamide |
Experimental Data
glyburide
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 4 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
glyburide
Statistics Data
glyburide
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 4 | 1 | 1 |
Statistics Data Visualization
glyburide
