Compound Summary
Compound Information
domperidone
Compound Name: | domperidone |
Compound CID: | 3151 |
Synonyms: | domperidone 57808-66-9 Motilium Nauzelin Domperidonum More... |
Iupac Name: | 6-chloro-3-[1-[3-(2-oxo-3H-benzimidazol-1-yl)propyl]piperidin-4-yl]-1H-benzimidazol-2-one |
InChI: | InChI=1S/C22H24ClN5O2/c23-15-6-7-20-18(14-15)25-22(30)28(20)16-8-12-26(13-9-16)10-3-11-27-19-5-2-1-4-17(19)24-21(27)29/h1-2,4-7,14,16H,3,8-13H2,(H,24,29)(H,25,30) |
InChIKey: | FGXWKSZFVQUSTL-UHFFFAOYSA-N |
Canonical Smiles: | C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O |
Isomeric Smiles: | C1CN(CCC1N2C3=C(C=C(C=C3)Cl)NC2=O)CCCN4C5=CC=CC=C5NC4=O |
Molecular Weight: | 425.9 |
Molecular Formula: | C22H24ClN5O2 |
Compound Structure
2D Structure:
3D Structure:
Computed Properties
domperidone
Molecular Weight: | 425.9 |
Molecular Formula: | C22H24ClN5O2 |
Hydrogen Bond Donor Count: | 2 |
Hydrogen Bond Acceptor Count: | 3 |
Rotatable Bond Count: | 5 |
Heavy Atom Count: | 30 |
Complexity: | 655 |
Synonyms
domperidone
| domperidone | domperidone |
|---|---|
domperidone |
57808-66-9 |
Motilium |
Nauzelin |
Domperidonum |
Domperidona |
4-(5-Chloro-2-oxo-1-benzimidazolinyl)-1-3-(2-oxobenzimidazolinyl)propylpiperidine |
R-33812 |
R 33,812 |
NSC299589 |
Domperidone (Motilium) |
5-Chloro-1-(1-(3-(2-oxo-1-benzimidazolinyl)propyl)-4-piperidyl)-2-benzimidazolinone |
R33812 |
UNII-5587267Z69 |
KW 5338 |
6-chloro-3-1-3-(2-oxo-3H-benzimidazol-1-yl)propylpiperidin-4-yl-1H-benzimidazol-2-one |
MLS000069343 |
CHEMBL219916 |
CHEBI:31515 |
MFCD00069256 |
NSC 299589 |
NSC-299589 |
5-Chloro-1-1-3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl-4-piperidinyl-1,3-dihydro-2H-benzimidazol-2-one |
5-chloro-1-{1-3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propylpiperidin-4-yl}-1,3-dihydro-2H-benzimidazol-2-one |
Motinorm |
Costi |
5-Chloro-1-1-3-(2-oxo-1-benzimidazolinyl)propyl-4-piperidyl-2-benzimidazolinone |
DSSTox_CID_25116 |
DSSTox_RID_80682 |
DSSTox_GSID_45116 |
1-(3-(4-(5-chloro-2-oxo-2,3-dihydrobenzodimidazol-1-yl)piperidin-1-yl)propyl)-1H-benzodimidazol-2(3H)-one |
5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzodimidazol-1-yl)propyl)piperidin-4-yl)-1H-benzodimidazol-2(3H)-one |
5-chloro-1-(1-(3-(2-oxo-2,3-dihydrobenzodimidazol-1-yl)propyl)piperidin-4-yl)-1H-benzodimidazol-2(3H)-one |
5-chloro-1-{1-3-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)propylpiperidin-4-yl}-2,3-dihydro-1H-1,3-benzodiazol-2-one |
5-Chloro-1-{1-3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one |
Domperidonum INN-Latin |
Domperidona INN-Spanish |
5587267Z69 |
Motillium |
Motilium (TN) |
SMR000326802 |
CAS-57808-66-9 |
KW-5338 |
Lopac-D-122 |
SR-01000003002 |
EINECS 260-968-7 |
BRN 0903774 |
Nauzelin OD |
Domperidone,(S) |
5-chloro-1-{1-3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one |
Domperidone USAN:INN:BAN:JAN |
Prestwick_794 |
NCI299589 |
HS-0067 |
Spectrum_000391 |
Opera_ID_616 |
SpecPlus_000825 |
Prestwick0_000461 |
Prestwick1_000461 |
Prestwick2_000461 |
Prestwick3_000461 |
Spectrum4_000087 |
D-122 |
Biomol-NT_000022 |
Domperidone - pharma grade |
NCIStruc1_001686 |
NCIStruc2_001819 |
Lopac0_000427 |
SCHEMBL43729 |
BSPBio_002350 |
GTPL965 |
KBioGR_000354 |
KBioSS_000871 |
2H-Benzimidazol-2-one, 5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro- |
5-24-02-00402 (Beilstein Handbook Reference) |
MLS000859942 |
MLS001306482 |
MLS002222324 |
DivK1c_006921 |
SPECTRUM2300212 |
SPBio_002501 |
BPBio1_000620 |
BPBio1_001185 |
DTXSID1045116 |
Domperidone (JP17/USAN/INN) |
KBio1_001865 |
KBio2_000871 |
KBio2_003439 |
KBio2_006007 |
HMS1922N04 |
HMS2089C14 |
HMS2093N22 |
HMS2096C21 |
HMS2230N18 |
HMS3261E16 |
HMS3269O13 |
HMS3370L03 |
HMS3413F15 |
HMS3656M21 |
HMS3677F15 |
HMS3713C21 |
HMS3884N19 |
Pharmakon1600-02300212 |
BCP28265 |
Domperidone 1.0 mg/ml in Methanol |
EBD46624 |
HY-B0411 |
ZINC4175569 |
Tox21_110056 |
Tox21_500427 |
BBL028136 |
BDBM50241107 |
CCG-37870 |
CD0227 |
NCGC00014670 |
NSC759575 |
s2461 |
STK622843 |
AKOS005555858 |
Tox21_110056_1 |
AC-2037 |
DB01184 |
Domperidone, powder, >=98% (HPLC) |
LP00427 |
MCULE-4430288884 |
NSC 759575 |
NSC-759575 |
SDCCGSBI-0050412.P004 |
NCGC00014670-01 |
NCGC00014670-02 |
NCGC00014670-03 |
NCGC00014670-04 |
NCGC00014670-05 |
NCGC00014670-06 |
NCGC00014670-07 |
NCGC00014670-08 |
NCGC00014670-09 |
NCGC00014670-10 |
NCGC00014670-11 |
NCGC00014670-12 |
NCGC00014670-13 |
NCGC00014670-14 |
NCGC00014670-16 |
NCGC00014670-17 |
NCGC00014670-28 |
NCGC00015306-01 |
NCGC00021472-02 |
NCGC00021472-03 |
NCGC00021472-04 |
NCGC00021472-05 |
NCGC00021472-06 |
NCGC00021472-07 |
NCGC00021472-08 |
NCGC00097773-01 |
NCGC00261112-01 |
2H-Benzimidazol-2-one, 1,3-dihydro-5-chloro-1-(1-(3-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)- |
5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl)-4-piperidinyl)-1,3-dihydro-2H-benzimidazol-2-one |
5-chloro-1-(1-(3-(2-oxo-2,3-dihydro-1H-benzodimidazol-1-yl)propyl)piperidin-4-yl)-1,3-dihydro-2H-benzodimidazol-2-one |
BD164379 |
NCI60_002512 |
SMR000058969 |
AB0110085 |
AB00052423 |
D4125 |
EU-0100427 |
FT-0625588 |
SW196931-3 |
C75710 |
D01745 |
AB00052423-06 |
AB00052423-07 |
AB00052423_08 |
AB00052423_09 |
808D669 |
A831618 |
L000230 |
Q424238 |
R 33812 |
SR-01000003002-2 |
SR-01000003002-4 |
SR-01000003002-7 |
W-105440 |
BRD-K38305202-001-02-6 |
BRD-K38305202-001-08-3 |
Domperidone, European Pharmacopoeia (EP) Reference Standard |
5-Chloro-1-1-3-(2-oxo-1-benzimidazolyl)propyl-4-piperidylbenzimidazol-2-one |
2H-Benzimidazol-2-one,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl-4-piperidinyl-1,3-dihydro- |
5-Chloro-1-1-3-(2,3-dihydro-2-oxo -1H-benzimidazol-1-yl)propyl-4-piperidinyl-1,3-d ihydro-2H-benzimidazol-2-one |
5-Chloro-1-1-3-(2-oxo-2,3-dihydro-1H-benzimidazol-1- yl)propylpiperidin-4-yl-1,3-dihydro-2H-benzimidazol-2-one |
5-chloro-1-1-3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propylpiperidine-4-yl-1,3-dihydro-2H-benzimidazol-2-one; |
5-chloro-1-{1-3(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)propyl-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one |
5-chloro-1-{1-3-(1,3-dihydro-2-oxo-2H-benzimidazol-1-yl)propyl-4-piperidinyl}-1,3-dihydro-2H-benzimidazol-2-one |
5-Chloro-1-{1-3-(2-hydroxy-2,3-dihydro-benzoimidazol-1-yl)-propyl-piperidin-4-yl}-2,3-dihydro-1H-benzoimidazol-2-ol |
5-Chloro-1-{1-3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one(domperidone) |
6-chloro-3-1-3-(2-oxo-3a,7a-dihydro-3H-benzimidazol-1-yl)propyl-4-piperidyl-3a,7a-dihydro-1H-benzimidazol-2-one |
DOMPERIDONE5-Chloro-1-{1-3-(2-oxo-2,3-dihydro-benzoimidazol-1-yl)-propyl-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one |
Experimental Data
domperidone
| Species | Dosage | Unit | CG Lifespan(AVG/MED days) | TG Lifespan(AVG/MED days) | Lifespan Change(AVG/MED%) | CG Lifespan(MAX days) | TG Lifespan(MAX days) | Lifespan Change(MAX%) | Significant | Strain | Gender | PubMed | Active Label |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Caenorhabditis elegans | 33 | umol/L | 6 | NS | N2 | 24134630 | Inactive |
Experimental Data Visualization
domperidone
Statistics Data
domperidone
| Species | Lifespan Change(AVG/MED%) | Lifespan Change(MAX%) | Count Reference | Count Data point |
|---|---|---|---|---|
| Caenorhabditis elegans | 6 | 1 | 1 |
Statistics Data Visualization
domperidone
