Compound Summary

  Compound Information
 wortmannin

Compound Name:

wortmannin

Compound CID:

312145

Synonyms:

wortmannin

19545-26-7

Wartmannin

KY 12420

Antibiotic SL-2052

More...

Iupac Name:

[(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo[10.6.1.02,10.05,9.015,19]nonadeca-2(10),12(19),14-trien-3-yl] acetate

InChI:

InChI=1S/C23H24O8/c1-10(24)30-13-7-22(2)12(5-6-14(22)25)16-18(13)23(3)15(9-28-4)31-21(27)11-8-29-20(17(11)23)19(16)26/h8,12-13,15H,5-7,9H2,1-4H3/t12-,13+,15+,22-,23-/m0/s1

InChIKey:

QDLHCMPXEPAAMD-QAIWCSMKSA-N

Canonical Smiles:

CC(=O)OC1CC2(C(CCC2=O)C3=C1C4(C(OC(=O)C5=COC(=C54)C3=O)COC)C)C

Isomeric Smiles:

CC(=O)O[C@@H]1C[C@]2([C@@H](CCC2=O)C3=C1[C@]4([C@H](OC(=O)C5=COC(=C54)C3=O)COC)C)C

Molecular Weight:

428.4

Molecular Formula:

C23H24O8

  Compound Structure
 2D Structure:
 3D Structure:
  Computed Properties
 wortmannin

Molecular Weight:

428.4

Molecular Formula:

C23H24O8

Hydrogen Bond Donor Count:

0

Hydrogen Bond Acceptor Count:

8

Rotatable Bond Count:

4

Heavy Atom Count:

31

Complexity:

921

  Synonyms
 wortmannin

wortmannin wortmannin

wortmannin

19545-26-7

Wartmannin

KY 12420

Antibiotic SL-2052

SL-2052

UNII-XVA4O219QW

MFCD00133927

NSC221019

XVA4O219QW

MLS002703028

CHEMBL428496

CHEBI:52289

(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo4,3,2-deindeno4,5-hisochromen-11-yl acetate

KY-12420

Pi 3-Kinase Inhibitor

(1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione

(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo10.6.1.0^{2,10}.0^{5,9}.0^{15,19}nonadeca-2(10),12(19),14-trien-3-yl acetate

(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo4,3,2-deindeno4,5-hisochromen-11-yl acetate

(1S,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-3,6,6b,7,8,9,9a,10,11,11b-decahydro-1H-furo4,3,2-deindeno4,5-hisochromen-11-yl acetate.

(1S,6bR,9aS,11R,11bR)-9a,11b-dimethyl-1-(methyloxy)methyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo4,3,2-deindeno4,5-hisochromen-11-yl acetate

wortmanin

C23H24O8

NSC627609

Wortmannin, Wm

nchembio866-comp1

NSC 627609

BRN 0067676

SCHEMBL4531

BSPBio_001232

4-19-00-03134 (Beilstein Handbook Reference)

cid_312145

GTPL6060

MEGxm0_000446

DTXSID8040642

Wortmannin, Ready Made Solution

Wortmannin,Penicillium wortmannin

ACon0_000951

BDBM15234

HMS1792N13

HMS1990N13

HMS3403N13

Wortmannin, Penicillium funiculosum

EX-A1930

ZINC1619592

2100AH

2803AH

s2758

ST-415

Wortmannin - CAS 19545-26-7

CCG-208290

CS-5073

DB08059

KY12420

NSC-221019

NSC-627609

Wortmannin, from Penicillium funiculosum

Wortmannin; SL-2052; KY-12420

NCGC00163485-01

NCGC00163485-02

BS-16306

HY-10197

NCI60_001835

SMR001566836

44665-EP2277881A1

44665-EP2277898A2

44665-EP2292227A2

44665-EP2301533A1

44665-EP2311818A1

CU-00000000011-1

J-012661

BRD-K87343924-001-02-4

3,2-DEINDENO4,5-H2BENZOPYRAN-11-YL ACETATE

Wortmannin solution, 100 mug/mL in acetonitrile, analytical standard

Wortmannin, from Penicillium funiculosum, >=98% (HPLC and TLC)

3H-furo4,3,2-deindeno4,5-h-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,

(1R,6bR,9aS,11R,11bR)-1-(methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b- decahydro-3H-furo4,3,2-deindeno4,5-hisochromen-11-yl acetate

(1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-(METHYLOXY)METHYL-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO4,

(1R,3R,5S,9R,18S)-18-(methoxymethyl)-1,5-dimethyl-6,11,16-trioxo-13,17-dioxapentacyclo10.6.1.02,10.05,9.015,19nonadeca-2(10),12(19),14-trien-3-yl acetate

2-Oxaandrosta-5,5,4-bcfuran-3,7,17-trione, 11-(acetyloxy)-1-(methoxymethyl)-, (1.alpha.,11.alpha.)-

3H-Furo4,2-deindeno4,5,-h-2-benzopyran-3,6,9-trione, 11-(Acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6br,9aS,11R,11bR)

3H-Furo4,2-deindeno4,5-h-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6br,9aS,11R,11bR)

3H-Furo4,3,2-deindeno4,5-h-2-benzopyran-3,6,9-trione, 11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-

3H-Furo4,3,2-deindeno4,5-h-2-benzopyran-3,6,9-trione,11-(acetyloxy)-1,6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-

6b,7,8,9a,10,11,11b-octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, (1S,6bR,9aS,11R,11bR)-

octahydro-1-(methoxymethyl)-9a,11b-dimethyl-, 1S-(1alpha,6baalpha,9abeta,11alpha,11bbeta)-
  Experimental Data
 wortmannin

Species Dosage Unit CG Lifespan(AVG/MED days) TG Lifespan(AVG/MED days) Lifespan Change(AVG/MED%) CG Lifespan(MAX days) TG Lifespan(MAX days) Lifespan Change(MAX%) Significant Strain Gender PubMed Active Label
Caenorhabditis elegans 50 umol/L 3.31 NS N2 30970250 Inactive
Caenorhabditis elegans 100 umol/L 16 18.05 12.78 S N2 33008901 Active
Caenorhabditis elegans 10 umol/L 17.02 16.41 -3.596 NS N2 33008901 Inactive
Drosophila melanogaster 5 mM 5 2 S Canton-S 24096697 Active
Caenorhabditis elegans 33 umol/L 17 NS N2 24134630 Inactive
Drosophila melanogaster 0.5 umol/L 34 35 0.03 48 72 0.5 NS Canton-S FEMALES 20017609 Inactive
Drosophila melanogaster 0.005 mM 8 4.8 NS Canton-S 24096697 Inactive
Drosophila melanogaster 5 mM -8.2 -1.7 S Canton-S 24096697 Inactive
Drosophila melanogaster 0.5 umol/L 37 39 0.05 46 64 0.39 S Canton-S MALES 20017609 Active
Drosophila melanogaster 0.005 mM 8 4.7 NS Canton-S 24096697 Inactive
Caenorhabditis elegans 1 umol/L -4.1 S N2 23543623 Inactive
  Experimental Data Visualization
 wortmannin

  Statistics Data
 wortmannin

Species Lifespan Change(AVG/MED%) Lifespan Change(MAX%) Count Reference Count Data point
Caenorhabditis elegans 17 4 5
Drosophila melanogaster 8 4.8 2 6
  Statistics Data Visualization
 wortmannin

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